Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV

Detalhes bibliográficos
Autor(a) principal: Müller, Pia
Data de Publicação: 2022
Outros Autores: Lapão, Luís Velez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/140463
Resumo: Funding Information: This study was funded by the Hans-Böckler Foundation (HBS - https://www.boeckler. de) and the Portuguese Foundation for Science and Technology (FCT - www.fct.pt). PM received a Research Scholarship from the HBS (Scholarship ID: 385759). LVL was funded by the FCT grants (UID/Multi/04413/2013 and UID/Multi/04413/2020). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to express our gratitude to Jonathan O' Mahony for proofreading the manuscript. In addition, we would like to thank Carlos Rodrigues, IT specialist at the Institute of Hygiene & Tropical Medicine in Lisbon, for his support with formatting the graphics included in this manuscript. Publisher Copyright: Copyright: © 2022 Müller, Velez Lapão. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIVInfectious DiseasesPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding Information: This study was funded by the Hans-Böckler Foundation (HBS - https://www.boeckler. de) and the Portuguese Foundation for Science and Technology (FCT - www.fct.pt). PM received a Research Scholarship from the HBS (Scholarship ID: 385759). LVL was funded by the FCT grants (UID/Multi/04413/2013 and UID/Multi/04413/2020). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to express our gratitude to Jonathan O' Mahony for proofreading the manuscript. In addition, we would like to thank Carlos Rodrigues, IT specialist at the Institute of Hygiene & Tropical Medicine in Lisbon, for his support with formatting the graphics included in this manuscript. Publisher Copyright: Copyright: © 2022 Müller, Velez Lapão. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background Cotrimoxazole and isoniazid preventive therapy (CPT, IPT) have been shown to be efficacious therapies for the prevention of opportunistic infections and tuberculosis (TB) among people living with human immunodeficiency virus (HIV). Despite governments' efforts to translate World Health Organization recommendations into practice, implementation remains challenging. This review aimed to explore and compare CPT and IPT with respect to similarities and differences of barriers identified across high TB/HIV burden countries. A secondary objective was to identify facilitators for implementing both preventive therapies. Methods We searched MEDLINE, Web of Science and SCOPUS databases for peer-reviewed literature published before September 2020. We extracted and synthesized our findings using Maxqda software. We applied framework synthesis in conjunction with metasummary to compare both therapies with respect to similarities and differences of barriers identified across seven health system components (in line with the modified WHO's Framework for action). Protocol registration: PROSPERO (CRD42019137778). Findings We identified four hundred and eighty-two papers, of which we included forty for review. Although most barrier themes were identical for both preventive therapies, we identified seven intervention-specific themes. Like for CPT, barriers identified for IPT were most frequently classified as 'service delivery-related barriers' and 'patient & community-related barriers'. 'Health provider-related barriers' played an important role for implementing IPT. Most facilitators identified referred to health system strengthening activities. Conclusions For researchers with limited working experience in high TB/HIV burden countries, this review can provide valuable insights about barriers that may arise at different levels of the health system. For policymakers in high TB/HIV burden countries, this review offers strategies for improving the delivery of IPT (or any newer therapy regimen) for the prevention of TB. Based on our findings, we suggest initial and continuous stakeholder involvement, focusing on the efficient use and reinforcement of existing resources for health.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Population health, policies and services (PPS)RUNMüller, PiaLapão, Luís Velez2022-06-21T22:25:07Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/140463eng1932-6203PURE: 44516409https://doi.org/10.1371/journal.pone.0251612info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:17:34Zoai:run.unl.pt:10362/140463Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:39.872243Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
title Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
spellingShingle Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
Müller, Pia
Infectious Diseases
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
title_short Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
title_full Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
title_fullStr Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
title_full_unstemmed Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
title_sort Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid-Preventive therapies for people living with HIV
author Müller, Pia
author_facet Müller, Pia
Lapão, Luís Velez
author_role author
author2 Lapão, Luís Velez
author2_role author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Population health, policies and services (PPS)
RUN
dc.contributor.author.fl_str_mv Müller, Pia
Lapão, Luís Velez
dc.subject.por.fl_str_mv Infectious Diseases
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
topic Infectious Diseases
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
description Funding Information: This study was funded by the Hans-Böckler Foundation (HBS - https://www.boeckler. de) and the Portuguese Foundation for Science and Technology (FCT - www.fct.pt). PM received a Research Scholarship from the HBS (Scholarship ID: 385759). LVL was funded by the FCT grants (UID/Multi/04413/2013 and UID/Multi/04413/2020). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to express our gratitude to Jonathan O' Mahony for proofreading the manuscript. In addition, we would like to thank Carlos Rodrigues, IT specialist at the Institute of Hygiene & Tropical Medicine in Lisbon, for his support with formatting the graphics included in this manuscript. Publisher Copyright: Copyright: © 2022 Müller, Velez Lapão. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-21T22:25:07Z
2022-03
2022-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url http://hdl.handle.net/10362/140463
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 1932-6203
PURE: 44516409
https://doi.org/10.1371/journal.pone.0251612
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eu_rights_str_mv openAccess
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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