Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities

Detalhes bibliográficos
Autor(a) principal: Araújo, Bruna
Data de Publicação: 2022
Outros Autores: Silva, Rita Caridade, Soares-Guedes, Carla, Martins-Macedo, Joana, Gomes, Eduardo Domingos Correia, Monteiro, Susana, Teixeira, Fábio Gabriel Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/80784
Resumo: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease.
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spelling Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunitiesParkinson’s diseaseNeuroinflammationInflammatory cellsAcute and chronic responsesGut-brain axisScience & TechnologyParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease.The present work was supported by Prémios Santa Casa Neurociências— Prize Mantero Belard for Neurodegenerative Diseases Research (MB-28-2019), the Portuguese Foundation for Science and Technology (FCT) to S.M. (CEECIND/01902/2017) and F.G.T. (2021.00643.CEECIND), the European Regional Development Fund (FEDER), the Competitiveness Internationalization Operational Programme (POCI), national funds through the Foundation for Science and Technology (FCT), under the scope of projects UIDB/50026/2020, UIDP/50026/2020, POCI-01-0145-FEDER-029751, and EXPL/MED-PAT/0931/2021, project NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), and under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoAraújo, BrunaSilva, Rita CaridadeSoares-Guedes, CarlaMartins-Macedo, JoanaGomes, Eduardo Domingos CorreiaMonteiro, SusanaTeixeira, Fábio Gabriel Rodrigues2022-09-172022-09-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80784engAraújo, B.; Caridade-Silva, R.; Soares-Guedes, C.; MartinsMacedo, J.; Gomes, E.D.; Monteiro, S.; Teixeira, F.G. Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities. Cells 2022, 11, 2908. https://doi.org/10.3390/ cells111829082073-440910.3390/cells11182908361394832908https://www.mdpi.com/2073-4409/11/18/2908info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:56:06Zoai:repositorium.sdum.uminho.pt:1822/80784Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:42.359757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
title Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
spellingShingle Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
Araújo, Bruna
Parkinson’s disease
Neuroinflammation
Inflammatory cells
Acute and chronic responses
Gut-brain axis
Science & Technology
title_short Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
title_full Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
title_fullStr Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
title_full_unstemmed Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
title_sort Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
author Araújo, Bruna
author_facet Araújo, Bruna
Silva, Rita Caridade
Soares-Guedes, Carla
Martins-Macedo, Joana
Gomes, Eduardo Domingos Correia
Monteiro, Susana
Teixeira, Fábio Gabriel Rodrigues
author_role author
author2 Silva, Rita Caridade
Soares-Guedes, Carla
Martins-Macedo, Joana
Gomes, Eduardo Domingos Correia
Monteiro, Susana
Teixeira, Fábio Gabriel Rodrigues
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Araújo, Bruna
Silva, Rita Caridade
Soares-Guedes, Carla
Martins-Macedo, Joana
Gomes, Eduardo Domingos Correia
Monteiro, Susana
Teixeira, Fábio Gabriel Rodrigues
dc.subject.por.fl_str_mv Parkinson’s disease
Neuroinflammation
Inflammatory cells
Acute and chronic responses
Gut-brain axis
Science & Technology
topic Parkinson’s disease
Neuroinflammation
Inflammatory cells
Acute and chronic responses
Gut-brain axis
Science & Technology
description Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-17
2022-09-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/80784
url https://hdl.handle.net/1822/80784
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Araújo, B.; Caridade-Silva, R.; Soares-Guedes, C.; MartinsMacedo, J.; Gomes, E.D.; Monteiro, S.; Teixeira, F.G. Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities. Cells 2022, 11, 2908. https://doi.org/10.3390/ cells11182908
2073-4409
10.3390/cells11182908
36139483
2908
https://www.mdpi.com/2073-4409/11/18/2908
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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