Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/80784 |
Resumo: | Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease. |
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Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunitiesParkinson’s diseaseNeuroinflammationInflammatory cellsAcute and chronic responsesGut-brain axisScience & TechnologyParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease.The present work was supported by Prémios Santa Casa Neurociências— Prize Mantero Belard for Neurodegenerative Diseases Research (MB-28-2019), the Portuguese Foundation for Science and Technology (FCT) to S.M. (CEECIND/01902/2017) and F.G.T. (2021.00643.CEECIND), the European Regional Development Fund (FEDER), the Competitiveness Internationalization Operational Programme (POCI), national funds through the Foundation for Science and Technology (FCT), under the scope of projects UIDB/50026/2020, UIDP/50026/2020, POCI-01-0145-FEDER-029751, and EXPL/MED-PAT/0931/2021, project NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), and under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoAraújo, BrunaSilva, Rita CaridadeSoares-Guedes, CarlaMartins-Macedo, JoanaGomes, Eduardo Domingos CorreiaMonteiro, SusanaTeixeira, Fábio Gabriel Rodrigues2022-09-172022-09-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80784engAraújo, B.; Caridade-Silva, R.; Soares-Guedes, C.; MartinsMacedo, J.; Gomes, E.D.; Monteiro, S.; Teixeira, F.G. Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities. Cells 2022, 11, 2908. https://doi.org/10.3390/ cells111829082073-440910.3390/cells11182908361394832908https://www.mdpi.com/2073-4409/11/18/2908info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:56:06Zoai:repositorium.sdum.uminho.pt:1822/80784Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:42.359757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
title |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
spellingShingle |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities Araújo, Bruna Parkinson’s disease Neuroinflammation Inflammatory cells Acute and chronic responses Gut-brain axis Science & Technology |
title_short |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
title_full |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
title_fullStr |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
title_full_unstemmed |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
title_sort |
Neuroinflammation and Parkinson’s disease - from neurodegeneration to therapeutic opportunities |
author |
Araújo, Bruna |
author_facet |
Araújo, Bruna Silva, Rita Caridade Soares-Guedes, Carla Martins-Macedo, Joana Gomes, Eduardo Domingos Correia Monteiro, Susana Teixeira, Fábio Gabriel Rodrigues |
author_role |
author |
author2 |
Silva, Rita Caridade Soares-Guedes, Carla Martins-Macedo, Joana Gomes, Eduardo Domingos Correia Monteiro, Susana Teixeira, Fábio Gabriel Rodrigues |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Araújo, Bruna Silva, Rita Caridade Soares-Guedes, Carla Martins-Macedo, Joana Gomes, Eduardo Domingos Correia Monteiro, Susana Teixeira, Fábio Gabriel Rodrigues |
dc.subject.por.fl_str_mv |
Parkinson’s disease Neuroinflammation Inflammatory cells Acute and chronic responses Gut-brain axis Science & Technology |
topic |
Parkinson’s disease Neuroinflammation Inflammatory cells Acute and chronic responses Gut-brain axis Science & Technology |
description |
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-17 2022-09-17T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/80784 |
url |
https://hdl.handle.net/1822/80784 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Araújo, B.; Caridade-Silva, R.; Soares-Guedes, C.; MartinsMacedo, J.; Gomes, E.D.; Monteiro, S.; Teixeira, F.G. Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities. Cells 2022, 11, 2908. https://doi.org/10.3390/ cells11182908 2073-4409 10.3390/cells11182908 36139483 2908 https://www.mdpi.com/2073-4409/11/18/2908 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132210694979584 |