An update of advanced nanoplatforms for Glioblastoma Multiforme Management

Detalhes bibliográficos
Autor(a) principal: Amaral, Mariana
Data de Publicação: 2021
Outros Autores: Cruz, Nuno, Ana Rosa, Nogueira, Beatriz, Costa, Diana, Santos, Francisco, Brazão, Mariana, Policarpo, Pedro, Mateus, Rita, Kobozev, Yan, Reis, Catarina Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51618
Resumo: Glioblastoma multiforme (GBM) is a very aggressive and heterogeneous glioma. Currently, GBM is treated with a combination of surgery, radiotherapy, chemotherapy (e.g. temozol­amide) and Tumour Treating Fields. Unfortunately, the mean survival is still around 15 months. This poor prognosis is associated with therapy resistance, tumor recurrence, and limited delivery of drugs due to the blood-brain barrier nature. Nanomedicine, the application of nanotechnology to medicine, has revolutionized many health fields, specifically cancer diagnosis and treatment. This review explores the particularities of different nanosystems (i.e., superparamagnetic, polymeric and gold nanoparticles, and liposomes) as well as how they can be applied to the treatment and diagnosis of GBM. As described, the most of the cited examples are on the preclinical phase; however, positive results were obtained and thus, the distance to achieve an effective treatment is shorter every day.
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spelling An update of advanced nanoplatforms for Glioblastoma Multiforme ManagementGlioblastoma multiformeNanosystemsSuperparamagnetic nanoparticlesPolymeric nanoparticlesLiposomesGold nanoparticlesGlioblastoma multiforme (GBM) is a very aggressive and heterogeneous glioma. Currently, GBM is treated with a combination of surgery, radiotherapy, chemotherapy (e.g. temozol­amide) and Tumour Treating Fields. Unfortunately, the mean survival is still around 15 months. This poor prognosis is associated with therapy resistance, tumor recurrence, and limited delivery of drugs due to the blood-brain barrier nature. Nanomedicine, the application of nanotechnology to medicine, has revolutionized many health fields, specifically cancer diagnosis and treatment. This review explores the particularities of different nanosystems (i.e., superparamagnetic, polymeric and gold nanoparticles, and liposomes) as well as how they can be applied to the treatment and diagnosis of GBM. As described, the most of the cited examples are on the preclinical phase; however, positive results were obtained and thus, the distance to achieve an effective treatment is shorter every day.This research was funded by Fundação para a Ciência e Tecnologia (FCT): Project Reference UIDB/04138/2020 and UIDP/04138/2020 but also the PhD fellowships SFRH/BD/ 05377/2021 and UI/BD/150754/2020.IfADo - Leibniz Research Centre for Working Environment and Human FactorsRepositório da Universidade de LisboaAmaral, MarianaCruz, NunoAna RosaNogueira, BeatrizCosta, DianaSantos, FranciscoBrazão, MarianaPolicarpo, PedroMateus, RitaKobozev, YanReis, Catarina Pinto2022-03-07T13:02:20Z2021-11-152022-02-21T09:18:42Z2021-11-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51618engAmaral M, Cruz N, Rosa A, Nogueira B, Costa D, Santos F, et al. An update of advanced nanoplatforms for Glioblastoma Multiforme Management. EXCLI Journal [Internet]. 2021;20:1544–70. Disponível em: https://www.excli.de/index.php/excli/article/view/43931611-2156cv-prod-2630678https://doi.org/10.17179/excli2021-4393info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:05Zoai:repositorio.ul.pt:10451/51618Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:42.154522Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An update of advanced nanoplatforms for Glioblastoma Multiforme Management
title An update of advanced nanoplatforms for Glioblastoma Multiforme Management
spellingShingle An update of advanced nanoplatforms for Glioblastoma Multiforme Management
Amaral, Mariana
Glioblastoma multiforme
Nanosystems
Superparamagnetic nanoparticles
Polymeric nanoparticles
Liposomes
Gold nanoparticles
title_short An update of advanced nanoplatforms for Glioblastoma Multiforme Management
title_full An update of advanced nanoplatforms for Glioblastoma Multiforme Management
title_fullStr An update of advanced nanoplatforms for Glioblastoma Multiforme Management
title_full_unstemmed An update of advanced nanoplatforms for Glioblastoma Multiforme Management
title_sort An update of advanced nanoplatforms for Glioblastoma Multiforme Management
author Amaral, Mariana
author_facet Amaral, Mariana
Cruz, Nuno
Ana Rosa
Nogueira, Beatriz
Costa, Diana
Santos, Francisco
Brazão, Mariana
Policarpo, Pedro
Mateus, Rita
Kobozev, Yan
Reis, Catarina Pinto
author_role author
author2 Cruz, Nuno
Ana Rosa
Nogueira, Beatriz
Costa, Diana
Santos, Francisco
Brazão, Mariana
Policarpo, Pedro
Mateus, Rita
Kobozev, Yan
Reis, Catarina Pinto
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Amaral, Mariana
Cruz, Nuno
Ana Rosa
Nogueira, Beatriz
Costa, Diana
Santos, Francisco
Brazão, Mariana
Policarpo, Pedro
Mateus, Rita
Kobozev, Yan
Reis, Catarina Pinto
dc.subject.por.fl_str_mv Glioblastoma multiforme
Nanosystems
Superparamagnetic nanoparticles
Polymeric nanoparticles
Liposomes
Gold nanoparticles
topic Glioblastoma multiforme
Nanosystems
Superparamagnetic nanoparticles
Polymeric nanoparticles
Liposomes
Gold nanoparticles
description Glioblastoma multiforme (GBM) is a very aggressive and heterogeneous glioma. Currently, GBM is treated with a combination of surgery, radiotherapy, chemotherapy (e.g. temozol­amide) and Tumour Treating Fields. Unfortunately, the mean survival is still around 15 months. This poor prognosis is associated with therapy resistance, tumor recurrence, and limited delivery of drugs due to the blood-brain barrier nature. Nanomedicine, the application of nanotechnology to medicine, has revolutionized many health fields, specifically cancer diagnosis and treatment. This review explores the particularities of different nanosystems (i.e., superparamagnetic, polymeric and gold nanoparticles, and liposomes) as well as how they can be applied to the treatment and diagnosis of GBM. As described, the most of the cited examples are on the preclinical phase; however, positive results were obtained and thus, the distance to achieve an effective treatment is shorter every day.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-15
2021-11-15T00:00:00Z
2022-03-07T13:02:20Z
2022-02-21T09:18:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51618
url http://hdl.handle.net/10451/51618
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amaral M, Cruz N, Rosa A, Nogueira B, Costa D, Santos F, et al. An update of advanced nanoplatforms for Glioblastoma Multiforme Management. EXCLI Journal [Internet]. 2021;20:1544–70. Disponível em: https://www.excli.de/index.php/excli/article/view/4393
1611-2156
cv-prod-2630678
https://doi.org/10.17179/excli2021-4393
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IfADo - Leibniz Research Centre for Working Environment and Human Factors
publisher.none.fl_str_mv IfADo - Leibniz Research Centre for Working Environment and Human Factors
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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