Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/52299 |
Resumo: | Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies. |
id |
RCAP_df84f1e6310f2a92ca6eb2b618894ea2 |
---|---|
oai_identifier_str |
oai:repositorio.ul.pt:10451/52299 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systemsnanotheranosticsgold nanoparticlespolymeric nanoparticleslipid-based nanosystemscancer treatmentcancer imagingTheranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UID/DTP/04138/2013, PTDC/MED-QUI/31721/2017 and for financial support through PhD fellowship SFRH/BD/117586/2016.MDPIRepositório da Universidade de LisboaSilva, Catarina OliveiraPinho, Jacinta OliveiraLopes, Joana MargaridaAlmeida, António JoséGaspar, Maria ManuelaReis, Catarina Pinto2022-04-12T13:23:25Z2019-01-082022-02-22T11:02:44Z2019-01-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52299engSilva CO, Pinho JO, Lopes JM, Almeida AJ, Gaspar MM, Reis C. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics [Internet]. 2019;11(1):22. Disponível em: https://www.mdpi.com/1999-4923/11/1/221999-4923cv-prod-2446113https://doi.org/10.3390/pharmaceutics11010022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:09Zoai:repositorio.ul.pt:10451/52299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:44.236444Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
title |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
spellingShingle |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems Silva, Catarina Oliveira nanotheranostics gold nanoparticles polymeric nanoparticles lipid-based nanosystems cancer treatment cancer imaging |
title_short |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
title_full |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
title_fullStr |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
title_full_unstemmed |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
title_sort |
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems |
author |
Silva, Catarina Oliveira |
author_facet |
Silva, Catarina Oliveira Pinho, Jacinta Oliveira Lopes, Joana Margarida Almeida, António José Gaspar, Maria Manuela Reis, Catarina Pinto |
author_role |
author |
author2 |
Pinho, Jacinta Oliveira Lopes, Joana Margarida Almeida, António José Gaspar, Maria Manuela Reis, Catarina Pinto |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Silva, Catarina Oliveira Pinho, Jacinta Oliveira Lopes, Joana Margarida Almeida, António José Gaspar, Maria Manuela Reis, Catarina Pinto |
dc.subject.por.fl_str_mv |
nanotheranostics gold nanoparticles polymeric nanoparticles lipid-based nanosystems cancer treatment cancer imaging |
topic |
nanotheranostics gold nanoparticles polymeric nanoparticles lipid-based nanosystems cancer treatment cancer imaging |
description |
Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-08 2019-01-08T00:00:00Z 2022-04-12T13:23:25Z 2022-02-22T11:02:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/52299 |
url |
http://hdl.handle.net/10451/52299 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva CO, Pinho JO, Lopes JM, Almeida AJ, Gaspar MM, Reis C. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics [Internet]. 2019;11(1):22. Disponível em: https://www.mdpi.com/1999-4923/11/1/22 1999-4923 cv-prod-2446113 https://doi.org/10.3390/pharmaceutics11010022 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134577128636416 |