Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Detalhes bibliográficos
Autor(a) principal: Silva, Catarina Oliveira
Data de Publicação: 2019
Outros Autores: Pinho, Jacinta Oliveira, Lopes, Joana Margarida, Almeida, António José, Gaspar, Maria Manuela, Reis, Catarina Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52299
Resumo: Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.
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spelling Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systemsnanotheranosticsgold nanoparticlespolymeric nanoparticleslipid-based nanosystemscancer treatmentcancer imagingTheranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UID/DTP/04138/2013, PTDC/MED-QUI/31721/2017 and for financial support through PhD fellowship SFRH/BD/117586/2016.MDPIRepositório da Universidade de LisboaSilva, Catarina OliveiraPinho, Jacinta OliveiraLopes, Joana MargaridaAlmeida, António JoséGaspar, Maria ManuelaReis, Catarina Pinto2022-04-12T13:23:25Z2019-01-082022-02-22T11:02:44Z2019-01-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52299engSilva CO, Pinho JO, Lopes JM, Almeida AJ, Gaspar MM, Reis C. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics [Internet]. 2019;11(1):22. Disponível em: https://www.mdpi.com/1999-4923/11/1/221999-4923cv-prod-2446113https://doi.org/10.3390/pharmaceutics11010022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:09Zoai:repositorio.ul.pt:10451/52299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:44.236444Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
title Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
spellingShingle Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
Silva, Catarina Oliveira
nanotheranostics
gold nanoparticles
polymeric nanoparticles
lipid-based nanosystems
cancer treatment
cancer imaging
title_short Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
title_full Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
title_fullStr Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
title_full_unstemmed Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
title_sort Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
author Silva, Catarina Oliveira
author_facet Silva, Catarina Oliveira
Pinho, Jacinta Oliveira
Lopes, Joana Margarida
Almeida, António José
Gaspar, Maria Manuela
Reis, Catarina Pinto
author_role author
author2 Pinho, Jacinta Oliveira
Lopes, Joana Margarida
Almeida, António José
Gaspar, Maria Manuela
Reis, Catarina Pinto
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Catarina Oliveira
Pinho, Jacinta Oliveira
Lopes, Joana Margarida
Almeida, António José
Gaspar, Maria Manuela
Reis, Catarina Pinto
dc.subject.por.fl_str_mv nanotheranostics
gold nanoparticles
polymeric nanoparticles
lipid-based nanosystems
cancer treatment
cancer imaging
topic nanotheranostics
gold nanoparticles
polymeric nanoparticles
lipid-based nanosystems
cancer treatment
cancer imaging
description Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-08
2019-01-08T00:00:00Z
2022-04-12T13:23:25Z
2022-02-22T11:02:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52299
url http://hdl.handle.net/10451/52299
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva CO, Pinho JO, Lopes JM, Almeida AJ, Gaspar MM, Reis C. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics [Internet]. 2019;11(1):22. Disponível em: https://www.mdpi.com/1999-4923/11/1/22
1999-4923
cv-prod-2446113
https://doi.org/10.3390/pharmaceutics11010022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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