Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial

Detalhes bibliográficos
Autor(a) principal: Silva, Adriana Ferreira
Data de Publicação: 2017
Outros Autores: Zortea, Maxciel, Carvalho, Sandra, Leite, Jorge, Torres, Iraci Lucena da Silva, Fregni, Felipe, Caumo, Wolnei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/63891
Resumo: Cognitive dysfunction in fibromyalgia patients has been reported, especially when increased attentional demands are required. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in modulating attention. We tested the effects of a single session of tDCS coupled with a Go/No-go task in modulating three distinct attentional networks: alertness, orienting and executive control. Secondarily, the effect on pain measures was evaluated. Forty females with fibromyalgia were randomized to receive active or sham tDCS. Anodal stimulation (1 mA, 20 min) was applied over the DLPFC. Attention indices were assessed using the Attention Network Test (ANT). Heat pain threshold (HPTh) and tolerance (HPTo) were measured. Active compared to sham tDCS led to increased performance in the orienting (mean difference [MD] = 14.63) and executive (MD = 21.00) attention networks. There was no effect on alertness. Active tDCS increased HPTh as compared to sham (MD = 1.93) and HPTo (MD = 1.52). Regression analysis showed the effect on executive attention is mostly independent of the effect on pain. DLPFC may be an important target for neurostimulation therapies in addition to the primary motor cortex for patients who do not respond adequately to neurostimulation therapies.
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spelling Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trialAdolescentAdultAgedExecutive FunctionFemaleFibromyalgiaHumansMiddle AgedPainPain ManagementPain ThresholdPrefrontal CortexPsychomotor PerformanceYoung AdultAttentionTranscranial Direct Current StimulationScience & TechnologyCognitive dysfunction in fibromyalgia patients has been reported, especially when increased attentional demands are required. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in modulating attention. We tested the effects of a single session of tDCS coupled with a Go/No-go task in modulating three distinct attentional networks: alertness, orienting and executive control. Secondarily, the effect on pain measures was evaluated. Forty females with fibromyalgia were randomized to receive active or sham tDCS. Anodal stimulation (1 mA, 20 min) was applied over the DLPFC. Attention indices were assessed using the Attention Network Test (ANT). Heat pain threshold (HPTh) and tolerance (HPTo) were measured. Active compared to sham tDCS led to increased performance in the orienting (mean difference [MD] = 14.63) and executive (MD = 21.00) attention networks. There was no effect on alertness. Active tDCS increased HPTh as compared to sham (MD = 1.93) and HPTo (MD = 1.52). Regression analysis showed the effect on executive attention is mostly independent of the effect on pain. DLPFC may be an important target for neurostimulation therapies in addition to the primary motor cortex for patients who do not respond adequately to neurostimulation therapies.This research was supported by grants and material support from the following Brazilian agencies: Committee for the Development of Higher Education Personnel - CAPES; International Cooperation Program - CAPES (023/11); Special Visitant Researcher Professor (No 71/2013) and material support (Prof Wolnei Caumo); National Council for Scientific and Technological Development - CNPq (grants to Dr. I.L.S. Torres, Dr. W. Caumo); Foundation for Support of Research at Rio Grande do Sul (FAPERGS). This research was supported by grants from the following Brazilian agencies: Brazilian Innovation Agency (FINEP) process number - 1245/13 (Caumo W).Nature ResearchUniversidade do MinhoSilva, Adriana FerreiraZortea, MaxcielCarvalho, SandraLeite, JorgeTorres, Iraci Lucena da SilvaFregni, FelipeCaumo, Wolnei20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63891eng2045-23222045-232210.1038/s41598-017-00185-w28273933https://www.nature.com/articles/s41598-017-00185-w.pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:16Zoai:repositorium.sdum.uminho.pt:1822/63891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:28.874008Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
title Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
spellingShingle Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
Silva, Adriana Ferreira
Adolescent
Adult
Aged
Executive Function
Female
Fibromyalgia
Humans
Middle Aged
Pain
Pain Management
Pain Threshold
Prefrontal Cortex
Psychomotor Performance
Young Adult
Attention
Transcranial Direct Current Stimulation
Science & Technology
title_short Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
title_full Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
title_fullStr Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
title_full_unstemmed Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
title_sort Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial
author Silva, Adriana Ferreira
author_facet Silva, Adriana Ferreira
Zortea, Maxciel
Carvalho, Sandra
Leite, Jorge
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
author_role author
author2 Zortea, Maxciel
Carvalho, Sandra
Leite, Jorge
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Adriana Ferreira
Zortea, Maxciel
Carvalho, Sandra
Leite, Jorge
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
dc.subject.por.fl_str_mv Adolescent
Adult
Aged
Executive Function
Female
Fibromyalgia
Humans
Middle Aged
Pain
Pain Management
Pain Threshold
Prefrontal Cortex
Psychomotor Performance
Young Adult
Attention
Transcranial Direct Current Stimulation
Science & Technology
topic Adolescent
Adult
Aged
Executive Function
Female
Fibromyalgia
Humans
Middle Aged
Pain
Pain Management
Pain Threshold
Prefrontal Cortex
Psychomotor Performance
Young Adult
Attention
Transcranial Direct Current Stimulation
Science & Technology
description Cognitive dysfunction in fibromyalgia patients has been reported, especially when increased attentional demands are required. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in modulating attention. We tested the effects of a single session of tDCS coupled with a Go/No-go task in modulating three distinct attentional networks: alertness, orienting and executive control. Secondarily, the effect on pain measures was evaluated. Forty females with fibromyalgia were randomized to receive active or sham tDCS. Anodal stimulation (1 mA, 20 min) was applied over the DLPFC. Attention indices were assessed using the Attention Network Test (ANT). Heat pain threshold (HPTh) and tolerance (HPTo) were measured. Active compared to sham tDCS led to increased performance in the orienting (mean difference [MD] = 14.63) and executive (MD = 21.00) attention networks. There was no effect on alertness. Active tDCS increased HPTh as compared to sham (MD = 1.93) and HPTo (MD = 1.52). Regression analysis showed the effect on executive attention is mostly independent of the effect on pain. DLPFC may be an important target for neurostimulation therapies in addition to the primary motor cortex for patients who do not respond adequately to neurostimulation therapies.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63891
url http://hdl.handle.net/1822/63891
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
2045-2322
10.1038/s41598-017-00185-w
28273933
https://www.nature.com/articles/s41598-017-00185-w.pdf
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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