Zebrafish as a disease model for studying human Rett Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/9535 |
Resumo: | Background: Rett syndrome (RTT) is a severe neurological disorder that affects almost exclusively females. This disease is characterized by normal growth and intellectual development until around the first year, then progression in development starts to slow down, with loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. Mutations in the X-linked genes methyl-CpG-binding protein 2 (MECP2) and cyclin-dependent kinase-like 5 (CDKL5) were described in RTT and recently several bone diseases related with decreased bone mass were also described in those patients, starting early in life. Because zebrafish was largely validated as a model for human diseases, the main objective of this work was to investigate if zebrafish can be a good model to study RTT. |
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Zebrafish as a disease model for studying human Rett SyndromeBackground: Rett syndrome (RTT) is a severe neurological disorder that affects almost exclusively females. This disease is characterized by normal growth and intellectual development until around the first year, then progression in development starts to slow down, with loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. Mutations in the X-linked genes methyl-CpG-binding protein 2 (MECP2) and cyclin-dependent kinase-like 5 (CDKL5) were described in RTT and recently several bone diseases related with decreased bone mass were also described in those patients, starting early in life. Because zebrafish was largely validated as a model for human diseases, the main objective of this work was to investigate if zebrafish can be a good model to study RTT.SapientiaVitorino, M.Conceicao, N.Adrião, Andreia Lúcia GonçalvesCancela, M. Leonor2017-04-07T15:56:49Z2016-042016-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/9535eng0014-2972info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:21:01Zoai:sapientia.ualg.pt:10400.1/9535Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:01:27.476617Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Zebrafish as a disease model for studying human Rett Syndrome |
title |
Zebrafish as a disease model for studying human Rett Syndrome |
spellingShingle |
Zebrafish as a disease model for studying human Rett Syndrome Vitorino, M. |
title_short |
Zebrafish as a disease model for studying human Rett Syndrome |
title_full |
Zebrafish as a disease model for studying human Rett Syndrome |
title_fullStr |
Zebrafish as a disease model for studying human Rett Syndrome |
title_full_unstemmed |
Zebrafish as a disease model for studying human Rett Syndrome |
title_sort |
Zebrafish as a disease model for studying human Rett Syndrome |
author |
Vitorino, M. |
author_facet |
Vitorino, M. Conceicao, N. Adrião, Andreia Lúcia Gonçalves Cancela, M. Leonor |
author_role |
author |
author2 |
Conceicao, N. Adrião, Andreia Lúcia Gonçalves Cancela, M. Leonor |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Vitorino, M. Conceicao, N. Adrião, Andreia Lúcia Gonçalves Cancela, M. Leonor |
description |
Background: Rett syndrome (RTT) is a severe neurological disorder that affects almost exclusively females. This disease is characterized by normal growth and intellectual development until around the first year, then progression in development starts to slow down, with loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. Mutations in the X-linked genes methyl-CpG-binding protein 2 (MECP2) and cyclin-dependent kinase-like 5 (CDKL5) were described in RTT and recently several bone diseases related with decreased bone mass were also described in those patients, starting early in life. Because zebrafish was largely validated as a model for human diseases, the main objective of this work was to investigate if zebrafish can be a good model to study RTT. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04 2016-04-01T00:00:00Z 2017-04-07T15:56:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/9535 |
url |
http://hdl.handle.net/10400.1/9535 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0014-2972 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133243930312704 |