Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women

Detalhes bibliográficos
Autor(a) principal: Palmeira, Lara
Data de Publicação: 2019
Outros Autores: Cunha, Marina, Padez, Cristina, Alvarez, Manuela, Pinto-Gouveia, José, Manco, Licínio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/11328/3506
Resumo: A population based case-control study was conducted in Portuguese women with overweight/obesity to investigate the possible association of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED). The distribution of seven polymorphisms was evaluated in 31 BED patients and 62 controls. No significant associations were found between polymorphisms and BED. Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402). Contrasting with anorexia nervosa and bulimia nervosa, our data suggest that rs9939609 A-allele has no potential role in BED.
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spelling Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese womenBED genetic susceptibilityFTO rs9939609 polymorphismObesityA population based case-control study was conducted in Portuguese women with overweight/obesity to investigate the possible association of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED). The distribution of seven polymorphisms was evaluated in 31 BED patients and 62 controls. No significant associations were found between polymorphisms and BED. Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402). Contrasting with anorexia nervosa and bulimia nervosa, our data suggest that rs9939609 A-allele has no potential role in BED.Elsevier2021-04-30T11:04:33Z2019-03-01T00:00:00Z2019-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11328/3506eng0165-1781DOI: 10.1016/j.psychres.2019.01.047Palmeira, LaraCunha, MarinaPadez, CristinaAlvarez, ManuelaPinto-Gouveia, JoséManco, Licínioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-15T02:11:59ZPortal AgregadorONG
dc.title.none.fl_str_mv Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
title Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
spellingShingle Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
Palmeira, Lara
BED genetic susceptibility
FTO rs9939609 polymorphism
Obesity
title_short Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
title_full Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
title_fullStr Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
title_full_unstemmed Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
title_sort Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
author Palmeira, Lara
author_facet Palmeira, Lara
Cunha, Marina
Padez, Cristina
Alvarez, Manuela
Pinto-Gouveia, José
Manco, Licínio
author_role author
author2 Cunha, Marina
Padez, Cristina
Alvarez, Manuela
Pinto-Gouveia, José
Manco, Licínio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Palmeira, Lara
Cunha, Marina
Padez, Cristina
Alvarez, Manuela
Pinto-Gouveia, José
Manco, Licínio
dc.subject.por.fl_str_mv BED genetic susceptibility
FTO rs9939609 polymorphism
Obesity
topic BED genetic susceptibility
FTO rs9939609 polymorphism
Obesity
description A population based case-control study was conducted in Portuguese women with overweight/obesity to investigate the possible association of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED). The distribution of seven polymorphisms was evaluated in 31 BED patients and 62 controls. No significant associations were found between polymorphisms and BED. Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402). Contrasting with anorexia nervosa and bulimia nervosa, our data suggest that rs9939609 A-allele has no potential role in BED.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-01T00:00:00Z
2019-03
2021-04-30T11:04:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/11328/3506
url http://hdl.handle.net/11328/3506
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0165-1781
DOI: 10.1016/j.psychres.2019.01.047
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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