Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes

Detalhes bibliográficos
Autor(a) principal: Querido, Sara
Data de Publicação: 2023
Outros Autores: Weigert, André, Pinto, Iola, Papoila, Ana Luísa, Pessanha, Maria Ana, Gomes, Perpétua, Adragão, Teresa, Paixão, Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158432
Resumo: Funding Information: Ana Luisa Papoila work is partially financed by national funds through FCT—Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020. Iola Pinto work is funded by national funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UIDB/00297/2020 and UIDP/00297/2020 (Center for Mathematics and Applications). Publisher Copyright: © 2023 Wiley Periodicals LLC.
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spelling Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomesBK virusJC viruskidney transplantationInfectious DiseasesVirologySDG 3 - Good Health and Well-beingFunding Information: Ana Luisa Papoila work is partially financed by national funds through FCT—Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020. Iola Pinto work is funded by national funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UIDB/00297/2020 and UIDP/00297/2020 (Center for Mathematics and Applications). Publisher Copyright: © 2023 Wiley Periodicals LLC.Studies analyzing the relationship between BK polyomavirus (BKV) or JC polyomavirus (JCV) infection and kidney transplant (KT) long term clinical outcomes are scarce. Therefore, we evaluated this relationship in a single-center retrospective cohort of 288 KT patients followed for 45.4(27.5; 62.5) months. Detection of BKV viremia in two consecutive analyses led to discontinuation of antimetabolite and initiation of mammalian target of rapamycin inhibitor. Outcome data included de novo BKV and/or JCV viremia and/or viruria after KT, death-censored graft survival and patient survival. BKV viruria and viremia were detected in 42.4% and 22.2% of KT recipients, respectively. BKV viremic patients had higher urinary BKV viral loads at the onset of viruria, when compared to nonviremic patients (7 log10 vs. 4.9 log10 cp/mL, p < 0.001). JCV viruria was identified in 38.5% of KT patients; the 5.9% of KT recipients who developed JCV viremia had higher JCV urinary viral loads at the onset of viruria, when compared to non-viremic patients (5.3 vs. 3.7 log10 cp/mL, p = 0.034). No differences were found in estimated glomerular filtration rate at the end of follow up, when comparing BKV or JCV viruric or viremic patients with nonviremic patients. No association was found between JCV or BKV viruria or viremia and death/graft failure. Therefore, higher BKV urinary viral loads at the onset could serve as an early maker of over immunosuppression. JCV and BKV replication was not associated with inferior clinical outcomes in KT patients with the above-mentioned immunosuppression strategy.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCMA - Centro de Matemática e AplicaçõesRUNQuerido, SaraWeigert, AndréPinto, IolaPapoila, Ana LuísaPessanha, Maria AnaGomes, PerpétuaAdragão, TeresaPaixão, Paulo2023-09-28T22:20:30Z2023-052023-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158432eng0146-6615PURE: 72181730https://doi.org/10.1002/jmv.28800info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:49Zoai:run.unl.pt:10362/158432Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:08.199412Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
title Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
spellingShingle Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
Querido, Sara
BK virus
JC virus
kidney transplantation
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
title_short Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
title_full Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
title_fullStr Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
title_full_unstemmed Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
title_sort Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes
author Querido, Sara
author_facet Querido, Sara
Weigert, André
Pinto, Iola
Papoila, Ana Luísa
Pessanha, Maria Ana
Gomes, Perpétua
Adragão, Teresa
Paixão, Paulo
author_role author
author2 Weigert, André
Pinto, Iola
Papoila, Ana Luísa
Pessanha, Maria Ana
Gomes, Perpétua
Adragão, Teresa
Paixão, Paulo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
CMA - Centro de Matemática e Aplicações
RUN
dc.contributor.author.fl_str_mv Querido, Sara
Weigert, André
Pinto, Iola
Papoila, Ana Luísa
Pessanha, Maria Ana
Gomes, Perpétua
Adragão, Teresa
Paixão, Paulo
dc.subject.por.fl_str_mv BK virus
JC virus
kidney transplantation
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
topic BK virus
JC virus
kidney transplantation
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
description Funding Information: Ana Luisa Papoila work is partially financed by national funds through FCT—Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020. Iola Pinto work is funded by national funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UIDB/00297/2020 and UIDP/00297/2020 (Center for Mathematics and Applications). Publisher Copyright: © 2023 Wiley Periodicals LLC.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-28T22:20:30Z
2023-05
2023-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158432
url http://hdl.handle.net/10362/158432
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0146-6615
PURE: 72181730
https://doi.org/10.1002/jmv.28800
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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