Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10284/12627 |
Resumo: | Individualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to produce 3D printed dosage forms based on two active pharmaceutical ingredients (APIs), ondansetron and esomeprazole, which are important for therapeutic customisation in paediatrics. Pre-formulation studies were carried out by characterising the physical and chemical properties of selected raw materials, selected APIs and their mixtures, using analytical methods such as scanning electron microscopy (SEM), X-ray powder diffraction (X-RPD), simultaneous thermal analysis (STA) and differential scanning calorimetry (DSC). The flowability of powders, compatibility and stability studies were also performed. Among all the ingredients selected, the PVPs (K17, K25 and K90) had the best characteristics to incorporate both forms of Esomeprazole Mg in a formulation to produce extrudates. The results obtained validated the use of some selected raw materials for tablet manufacture by the 3D printing approach. |
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Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies3D printingPaediatricEsomeprazoleOndansetronPre-formulation studiesIndividualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to produce 3D printed dosage forms based on two active pharmaceutical ingredients (APIs), ondansetron and esomeprazole, which are important for therapeutic customisation in paediatrics. Pre-formulation studies were carried out by characterising the physical and chemical properties of selected raw materials, selected APIs and their mixtures, using analytical methods such as scanning electron microscopy (SEM), X-ray powder diffraction (X-RPD), simultaneous thermal analysis (STA) and differential scanning calorimetry (DSC). The flowability of powders, compatibility and stability studies were also performed. Among all the ingredients selected, the PVPs (K17, K25 and K90) had the best characteristics to incorporate both forms of Esomeprazole Mg in a formulation to produce extrudates. The results obtained validated the use of some selected raw materials for tablet manufacture by the 3D printing approach.MDPIRepositório Institucional da Universidade Fernando PessoaFerreira, MarianaLopes, Carla MartinsGonçalves, HugoPinto, João F.Catita, José2024-01-30T15:11:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/12627engFerreira, M.; Lopes, C.M.; Gonçalves, H.; Pinto, J.F.; Catita, J. Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies. Applied Sciences 2022, 12, 10585. https://doi.org/10.3390/ app12201058510.3390/app1220105852076-3417info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-06T02:01:33Zoai:bdigital.ufp.pt:10284/12627Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:13:52.342227Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
title |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
spellingShingle |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies Ferreira, Mariana 3D printing Paediatric Esomeprazole Ondansetron Pre-formulation studies |
title_short |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
title_full |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
title_fullStr |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
title_full_unstemmed |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
title_sort |
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies |
author |
Ferreira, Mariana |
author_facet |
Ferreira, Mariana Lopes, Carla Martins Gonçalves, Hugo Pinto, João F. Catita, José |
author_role |
author |
author2 |
Lopes, Carla Martins Gonçalves, Hugo Pinto, João F. Catita, José |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Institucional da Universidade Fernando Pessoa |
dc.contributor.author.fl_str_mv |
Ferreira, Mariana Lopes, Carla Martins Gonçalves, Hugo Pinto, João F. Catita, José |
dc.subject.por.fl_str_mv |
3D printing Paediatric Esomeprazole Ondansetron Pre-formulation studies |
topic |
3D printing Paediatric Esomeprazole Ondansetron Pre-formulation studies |
description |
Individualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to produce 3D printed dosage forms based on two active pharmaceutical ingredients (APIs), ondansetron and esomeprazole, which are important for therapeutic customisation in paediatrics. Pre-formulation studies were carried out by characterising the physical and chemical properties of selected raw materials, selected APIs and their mixtures, using analytical methods such as scanning electron microscopy (SEM), X-ray powder diffraction (X-RPD), simultaneous thermal analysis (STA) and differential scanning calorimetry (DSC). The flowability of powders, compatibility and stability studies were also performed. Among all the ingredients selected, the PVPs (K17, K25 and K90) had the best characteristics to incorporate both forms of Esomeprazole Mg in a formulation to produce extrudates. The results obtained validated the use of some selected raw materials for tablet manufacture by the 3D printing approach. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2024-01-30T15:11:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10284/12627 |
url |
http://hdl.handle.net/10284/12627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, M.; Lopes, C.M.; Gonçalves, H.; Pinto, J.F.; Catita, J. Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies. Applied Sciences 2022, 12, 10585. https://doi.org/10.3390/ app122010585 10.3390/app122010585 2076-3417 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137240983535616 |