A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)

Detalhes bibliográficos
Autor(a) principal: Caldeira, M. Madalena
Data de Publicação: 2000
Outros Autores: Ramos, M. Luísa, Pereira, Gilberto G., Gil, Victor M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5250
Resumo: Meso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n).
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spelling A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)meso-2,3-dimercaptosuccinic acidMultinuclear NMRTunsgstenMeso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n).http://www.sciencedirect.com/science/article/B6TH8-40NG3G0-15/1/148f75794ab8134c22a0790b94e679152000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5250http://hdl.handle.net/10316/5250engPolyhedron. 19:2 (2000) 193-197Caldeira, M. MadalenaRamos, M. LuísaPereira, Gilberto G.Gil, Victor M. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T10:05:30Zoai:estudogeral.uc.pt:10316/5250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:23.136245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
title A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
spellingShingle A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
Caldeira, M. Madalena
meso-2,3-dimercaptosuccinic acid
Multinuclear NMR
Tunsgsten
title_short A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
title_full A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
title_fullStr A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
title_full_unstemmed A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
title_sort A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
author Caldeira, M. Madalena
author_facet Caldeira, M. Madalena
Ramos, M. Luísa
Pereira, Gilberto G.
Gil, Victor M. S.
author_role author
author2 Ramos, M. Luísa
Pereira, Gilberto G.
Gil, Victor M. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Caldeira, M. Madalena
Ramos, M. Luísa
Pereira, Gilberto G.
Gil, Victor M. S.
dc.subject.por.fl_str_mv meso-2,3-dimercaptosuccinic acid
Multinuclear NMR
Tunsgsten
topic meso-2,3-dimercaptosuccinic acid
Multinuclear NMR
Tunsgsten
description Meso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n).
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5250
http://hdl.handle.net/10316/5250
url http://hdl.handle.net/10316/5250
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Polyhedron. 19:2 (2000) 193-197
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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