A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/5250 |
Resumo: | Meso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n). |
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A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA)meso-2,3-dimercaptosuccinic acidMultinuclear NMRTunsgstenMeso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n).http://www.sciencedirect.com/science/article/B6TH8-40NG3G0-15/1/148f75794ab8134c22a0790b94e679152000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5250http://hdl.handle.net/10316/5250engPolyhedron. 19:2 (2000) 193-197Caldeira, M. MadalenaRamos, M. LuísaPereira, Gilberto G.Gil, Victor M. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T10:05:30Zoai:estudogeral.uc.pt:10316/5250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:23.136245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
title |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
spellingShingle |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) Caldeira, M. Madalena meso-2,3-dimercaptosuccinic acid Multinuclear NMR Tunsgsten |
title_short |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
title_full |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
title_fullStr |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
title_full_unstemmed |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
title_sort |
A multinuclear NMR study of the complexation of W(VI) with meso-2,3-dimercaptosuccinic acid (DMSA) |
author |
Caldeira, M. Madalena |
author_facet |
Caldeira, M. Madalena Ramos, M. Luísa Pereira, Gilberto G. Gil, Victor M. S. |
author_role |
author |
author2 |
Ramos, M. Luísa Pereira, Gilberto G. Gil, Victor M. S. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Caldeira, M. Madalena Ramos, M. Luísa Pereira, Gilberto G. Gil, Victor M. S. |
dc.subject.por.fl_str_mv |
meso-2,3-dimercaptosuccinic acid Multinuclear NMR Tunsgsten |
topic |
meso-2,3-dimercaptosuccinic acid Multinuclear NMR Tunsgsten |
description |
Meso-2,3-dimercaptosuccinic acid (DMSA), which is used as an antidote for heavy metal poisoning and in complexes of 99mTc for diagnostic purposes, forms several complexes with tungsten(VI) in aqueous solutions, as found by 1H, 13C, 17O and 183W NMR spectroscopy. In the pH range ~4-7, there are four complexes in which the acid acts as a bidentate ligand through one carboxyl group and the adjacent sulfhydryl group (a dominant 2:2 species and three 1:2 metal-ligand isomers are proposed) and 2:1 complexes in which the ligand is twisted in order to use the four binding groups. It is proposed that in both the 2:2 and 2:1 cases the S atoms bridge the two W atoms. At lower pH, the acid is again predominantly a tetradentate ligand in m:n associations with the metal (m>n). |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/5250 http://hdl.handle.net/10316/5250 |
url |
http://hdl.handle.net/10316/5250 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Polyhedron. 19:2 (2000) 193-197 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133905341644800 |