Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/426 |
Resumo: | Chromosomal rearrangements are mutations contributing to both within and between species variation; however their contribution to fitness is yet to be measured. Here we show that chromosomal rearrangements are pervasive in natural isolates of Schizosaccharomyces pombe and contribute to reproductive isolation. To determine the fitness effects of chromosome structure, we constructed two inversions and eight translocations without changing the coding sequence. We show that chromosomal rearrangements contribute to both reproductive success in meiosis and growth rate in mitosis with a strong genotype by environment interaction. These changes are accompanied by alterations in gene expression. Strikingly, we find several examples leading to antagonistic pleiotropy. Even though chromosomal rearrangements may have a deleterious effect during sexual reproduction, some compensate with a strong growth advantage in mitosis. Our results constitute the first quantification of fitness effects caused by de novo mutations that result in chromosomal rearrangement variation and suggest a mechanism for their maintenance in natural populations. |
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Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropyBiological sciencesEvolutionGeneticsChromosomal rearrangements are mutations contributing to both within and between species variation; however their contribution to fitness is yet to be measured. Here we show that chromosomal rearrangements are pervasive in natural isolates of Schizosaccharomyces pombe and contribute to reproductive isolation. To determine the fitness effects of chromosome structure, we constructed two inversions and eight translocations without changing the coding sequence. We show that chromosomal rearrangements contribute to both reproductive success in meiosis and growth rate in mitosis with a strong genotype by environment interaction. These changes are accompanied by alterations in gene expression. Strikingly, we find several examples leading to antagonistic pleiotropy. Even though chromosomal rearrangements may have a deleterious effect during sexual reproduction, some compensate with a strong growth advantage in mitosis. Our results constitute the first quantification of fitness effects caused by de novo mutations that result in chromosomal rearrangement variation and suggest a mechanism for their maintenance in natural populations.FCT PhD and Postdoctoral fellowships.Nature Publishing GroupARCATeresa Avelar, AnaPerfeito, LíliaGordo, IsabelGodinho Ferreira, Miguel2015-10-22T10:24:35Z2013-08-232013-08-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/426engAvelar, A. T. et al. Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy. Nat. Commun. 4:2235 doi: 10.1038/ncomms3235 (2013).10.1038/ncomms3235info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:49Zoai:arca.igc.gulbenkian.pt:10400.7/426Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:43.099291Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
title |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
spellingShingle |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy Teresa Avelar, Ana Biological sciences Evolution Genetics |
title_short |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
title_full |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
title_fullStr |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
title_full_unstemmed |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
title_sort |
Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy |
author |
Teresa Avelar, Ana |
author_facet |
Teresa Avelar, Ana Perfeito, Lília Gordo, Isabel Godinho Ferreira, Miguel |
author_role |
author |
author2 |
Perfeito, Lília Gordo, Isabel Godinho Ferreira, Miguel |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Teresa Avelar, Ana Perfeito, Lília Gordo, Isabel Godinho Ferreira, Miguel |
dc.subject.por.fl_str_mv |
Biological sciences Evolution Genetics |
topic |
Biological sciences Evolution Genetics |
description |
Chromosomal rearrangements are mutations contributing to both within and between species variation; however their contribution to fitness is yet to be measured. Here we show that chromosomal rearrangements are pervasive in natural isolates of Schizosaccharomyces pombe and contribute to reproductive isolation. To determine the fitness effects of chromosome structure, we constructed two inversions and eight translocations without changing the coding sequence. We show that chromosomal rearrangements contribute to both reproductive success in meiosis and growth rate in mitosis with a strong genotype by environment interaction. These changes are accompanied by alterations in gene expression. Strikingly, we find several examples leading to antagonistic pleiotropy. Even though chromosomal rearrangements may have a deleterious effect during sexual reproduction, some compensate with a strong growth advantage in mitosis. Our results constitute the first quantification of fitness effects caused by de novo mutations that result in chromosomal rearrangement variation and suggest a mechanism for their maintenance in natural populations. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-23 2013-08-23T00:00:00Z 2015-10-22T10:24:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/426 |
url |
http://hdl.handle.net/10400.7/426 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Avelar, A. T. et al. Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy. Nat. Commun. 4:2235 doi: 10.1038/ncomms3235 (2013). 10.1038/ncomms3235 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130572895813632 |