Immune parameters for diagnosis and treatment monitoring in invasive mold infection
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/63452 |
Resumo: | Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections. |
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Immune parameters for diagnosis and treatment monitoring in invasive mold infectionAspergillusinvasive aspergillosisinvasive mold infectionsimmune responseMucormycosisprognosismold-reactive T-cellsinterleukin 6interleukin 8interleukin 10Science & TechnologyInfections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections.This research was supported in part by Gilead Sciences Grant IN-EU-131-5720.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoJenks, Jeffrey D.Rawlings, Stephen AGarcia-Vidal, CarolKoehler, PhilippMercier, ToinePrattes, JuergenLass-Flörl, CorneliaMartin-Gomez, M TeresaBuchheidt, DieterPagano, LivioGangneux, Jean-Pierrevan de Veerdonk, Frank L.Netea, Mihai G.Carvalho, AgostinhoHoenigl, Martin20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63452engJenks, J.D.; Rawlings, S.A.; Garcia-Vidal, C.; Koehler, P.; Mercier, T.; Prattes, J.; Lass-Flörl, C.; Martin-Gomez, M.T.; Buchheidt, D.; Pagano, L.; Gangneux, J.-P.; van de Veerdonk, F.L.; Netea, M.G.; Carvalho, A.; Hoenigl, M., on behalf of ECMM working group Immunologic Markers for Treatment Monitoring and Diagnosis in Invasive Mold Infection; Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection. J. Fungi 2019, 5, 116.2309-608X10.3390/jof5040116https://www.mdpi.com/2309-608X/5/4/116info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:40:42Zoai:repositorium.sdum.uminho.pt:1822/63452Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:37:33.649562Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
title |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
spellingShingle |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection Jenks, Jeffrey D. Aspergillus invasive aspergillosis invasive mold infections immune response Mucormycosis prognosis mold-reactive T-cells interleukin 6 interleukin 8 interleukin 10 Science & Technology |
title_short |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
title_full |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
title_fullStr |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
title_full_unstemmed |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
title_sort |
Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
author |
Jenks, Jeffrey D. |
author_facet |
Jenks, Jeffrey D. Rawlings, Stephen A Garcia-Vidal, Carol Koehler, Philipp Mercier, Toine Prattes, Juergen Lass-Flörl, Cornelia Martin-Gomez, M Teresa Buchheidt, Dieter Pagano, Livio Gangneux, Jean-Pierre van de Veerdonk, Frank L. Netea, Mihai G. Carvalho, Agostinho Hoenigl, Martin |
author_role |
author |
author2 |
Rawlings, Stephen A Garcia-Vidal, Carol Koehler, Philipp Mercier, Toine Prattes, Juergen Lass-Flörl, Cornelia Martin-Gomez, M Teresa Buchheidt, Dieter Pagano, Livio Gangneux, Jean-Pierre van de Veerdonk, Frank L. Netea, Mihai G. Carvalho, Agostinho Hoenigl, Martin |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Jenks, Jeffrey D. Rawlings, Stephen A Garcia-Vidal, Carol Koehler, Philipp Mercier, Toine Prattes, Juergen Lass-Flörl, Cornelia Martin-Gomez, M Teresa Buchheidt, Dieter Pagano, Livio Gangneux, Jean-Pierre van de Veerdonk, Frank L. Netea, Mihai G. Carvalho, Agostinho Hoenigl, Martin |
dc.subject.por.fl_str_mv |
Aspergillus invasive aspergillosis invasive mold infections immune response Mucormycosis prognosis mold-reactive T-cells interleukin 6 interleukin 8 interleukin 10 Science & Technology |
topic |
Aspergillus invasive aspergillosis invasive mold infections immune response Mucormycosis prognosis mold-reactive T-cells interleukin 6 interleukin 8 interleukin 10 Science & Technology |
description |
Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/63452 |
url |
http://hdl.handle.net/1822/63452 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jenks, J.D.; Rawlings, S.A.; Garcia-Vidal, C.; Koehler, P.; Mercier, T.; Prattes, J.; Lass-Flörl, C.; Martin-Gomez, M.T.; Buchheidt, D.; Pagano, L.; Gangneux, J.-P.; van de Veerdonk, F.L.; Netea, M.G.; Carvalho, A.; Hoenigl, M., on behalf of ECMM working group Immunologic Markers for Treatment Monitoring and Diagnosis in Invasive Mold Infection; Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection. J. Fungi 2019, 5, 116. 2309-608X 10.3390/jof5040116 https://www.mdpi.com/2309-608X/5/4/116 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132909415694336 |