Long term trends in prevalence of neural tube defects in Europe: population based study
| Autor(a) principal: | |
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| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/3396 |
Resumo: | Comment in: Mills JL, Dimopoulos A. Folic acid fortification for Europe? BMJ. 2015 Nov 24;351:h6198. doi: 10.1136/bmj.h6198. |
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Long term trends in prevalence of neural tube defects in Europe: population based studyNeural Tube DefectFolic AcidTrendsPrevalenceCongenital AnomaliesPrenatal DiagnosisPrevention and ControlFetal DeathDietary SupplementsPregnancyEuropePortugalEuropean Surveillance of Congenital AnomaliesNacional Registry of Congenital AnomaliesEUROCATRENACEstados de Saúde e de DoençaDeterminantes da Saúde e da DoençaComment in: Mills JL, Dimopoulos A. Folic acid fortification for Europe? BMJ. 2015 Nov 24;351:h6198. doi: 10.1136/bmj.h6198.Study question: What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid fortification of food does not exist? Methods: This was a population based, observational study using data on 11 353 cases of NTD not associated with chromosomal anomalies, including 4162 cases of anencephaly and 5776 cases of spina bifida from 28 EUROCAT (European Surveillance of Congenital Anomalies) registries covering approximately 12.5 million births in 19 countries between 1991 and 2011. The main outcome measures were total and live birth prevalence of NTD, as well as anencephaly and spina bifida, with time trends analysed using random effects Poisson regression models to account for heterogeneities across registries and splines to model non-linear time trends. Summary answer and limitations: Overall, the pooled total prevalence of NTD during the study period was 9.1 per 10 000 births. Prevalence of NTD fluctuated slightly but without an obvious downward trend, with the final estimate of the pooled total prevalence of NTD in 2011 similar to that in 1991. Estimates from Poisson models that took registry heterogeneities into account showed an annual increase of 4% (prevalence ratio 1.04, 95% confidence interval 1.01 to 1.07) in 1995-99 and a decrease of 3% per year in 1999-2003 (0.97, 0.95 to 0.99), with stable rates thereafter. The trend patterns for anencephaly and spina bifida were similar, but neither anomaly decreased substantially over time. The live birth prevalence of NTD generally decreased, especially for anencephaly. Registration problems or other data artefacts cannot be excluded as a partial explanation of the observed trends (or lack thereof) in the prevalence of NTD. What this study adds: In the absence of mandatory fortification, the prevalence of NTD has not decreased in Europe despite longstanding recommendations aimed at promoting peri-conceptional folic acid supplementation and existence of voluntary folic acid fortification.The study was funded by the European Public Health Commission, EUROCAT Joint Action 2011-2013. HD and ML received support from the European Commission DG Sanco during the conduct of this study.BMJ Publishing GroupRepositório Científico do Instituto Nacional de SaúdeKhoshnood, BabakLoane, MariaWalle, Hermien deArriola, LarraitzAddor, Marie-ClaudeBarisic, IngeborgBeres, JuditBianchi, FabrizioDias, Carlos MatiasDraper, ElizabethGarne, EsterGatt, MiriamHaeusler, MartinKlungsoyr, KariLatos-Bielenska, AnnaLynch, CatherineMcDonnell, BobNelen, VeraNeville, Amanda J.O’Mahony, Mary T.Queisser-Luft, AnnetteRankin, JudithRissmann, AnkeRitvanen, AnnukkaRounding, CatherineSipek, AntoninTucker, DavidVerellen-Dumoulin, ChristineWellesley, DianaDolk, Helen2016-02-17T18:06:47Z2015-10-142015-10-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3396engBMJ. 2015 Nov 24;351:h5949. doi: 10.1136/bmj.h59490959-813810.1136/bmj.h5949info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:45Zoai:repositorio.insa.pt:10400.18/3396Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:14.813427Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| title |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| spellingShingle |
Long term trends in prevalence of neural tube defects in Europe: population based study Khoshnood, Babak Neural Tube Defect Folic Acid Trends Prevalence Congenital Anomalies Prenatal Diagnosis Prevention and Control Fetal Death Dietary Supplements Pregnancy Europe Portugal European Surveillance of Congenital Anomalies Nacional Registry of Congenital Anomalies EUROCAT RENAC Estados de Saúde e de Doença Determinantes da Saúde e da Doença |
| title_short |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| title_full |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| title_fullStr |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| title_full_unstemmed |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| title_sort |
Long term trends in prevalence of neural tube defects in Europe: population based study |
| author |
Khoshnood, Babak |
| author_facet |
Khoshnood, Babak Loane, Maria Walle, Hermien de Arriola, Larraitz Addor, Marie-Claude Barisic, Ingeborg Beres, Judit Bianchi, Fabrizio Dias, Carlos Matias Draper, Elizabeth Garne, Ester Gatt, Miriam Haeusler, Martin Klungsoyr, Kari Latos-Bielenska, Anna Lynch, Catherine McDonnell, Bob Nelen, Vera Neville, Amanda J. O’Mahony, Mary T. Queisser-Luft, Annette Rankin, Judith Rissmann, Anke Ritvanen, Annukka Rounding, Catherine Sipek, Antonin Tucker, David Verellen-Dumoulin, Christine Wellesley, Diana Dolk, Helen |
| author_role |
author |
| author2 |
Loane, Maria Walle, Hermien de Arriola, Larraitz Addor, Marie-Claude Barisic, Ingeborg Beres, Judit Bianchi, Fabrizio Dias, Carlos Matias Draper, Elizabeth Garne, Ester Gatt, Miriam Haeusler, Martin Klungsoyr, Kari Latos-Bielenska, Anna Lynch, Catherine McDonnell, Bob Nelen, Vera Neville, Amanda J. O’Mahony, Mary T. Queisser-Luft, Annette Rankin, Judith Rissmann, Anke Ritvanen, Annukka Rounding, Catherine Sipek, Antonin Tucker, David Verellen-Dumoulin, Christine Wellesley, Diana Dolk, Helen |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Khoshnood, Babak Loane, Maria Walle, Hermien de Arriola, Larraitz Addor, Marie-Claude Barisic, Ingeborg Beres, Judit Bianchi, Fabrizio Dias, Carlos Matias Draper, Elizabeth Garne, Ester Gatt, Miriam Haeusler, Martin Klungsoyr, Kari Latos-Bielenska, Anna Lynch, Catherine McDonnell, Bob Nelen, Vera Neville, Amanda J. O’Mahony, Mary T. Queisser-Luft, Annette Rankin, Judith Rissmann, Anke Ritvanen, Annukka Rounding, Catherine Sipek, Antonin Tucker, David Verellen-Dumoulin, Christine Wellesley, Diana Dolk, Helen |
| dc.subject.por.fl_str_mv |
Neural Tube Defect Folic Acid Trends Prevalence Congenital Anomalies Prenatal Diagnosis Prevention and Control Fetal Death Dietary Supplements Pregnancy Europe Portugal European Surveillance of Congenital Anomalies Nacional Registry of Congenital Anomalies EUROCAT RENAC Estados de Saúde e de Doença Determinantes da Saúde e da Doença |
| topic |
Neural Tube Defect Folic Acid Trends Prevalence Congenital Anomalies Prenatal Diagnosis Prevention and Control Fetal Death Dietary Supplements Pregnancy Europe Portugal European Surveillance of Congenital Anomalies Nacional Registry of Congenital Anomalies EUROCAT RENAC Estados de Saúde e de Doença Determinantes da Saúde e da Doença |
| description |
Comment in: Mills JL, Dimopoulos A. Folic acid fortification for Europe? BMJ. 2015 Nov 24;351:h6198. doi: 10.1136/bmj.h6198. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-10-14 2015-10-14T00:00:00Z 2016-02-17T18:06:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/3396 |
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http://hdl.handle.net/10400.18/3396 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
BMJ. 2015 Nov 24;351:h5949. doi: 10.1136/bmj.h5949 0959-8138 10.1136/bmj.h5949 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group |
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BMJ Publishing Group |
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