Prevalence of microcephaly in Europe: population based study
| Autor(a) principal: | |
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| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/4464 |
Resumo: | Co-autor: Carlos Matias Dias - Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorge |
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Prevalence of microcephaly in Europe: population based studyMicrocefaliaEstados de Saúde e de DoençaObservação em Saúde e VigilânciaRENACEUROCATEuropean Surveillance of Congenital AnomaliesEuropean SurveillanceCongenital AnomaliesEuropeCo-autor: Carlos Matias Dias - Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo JorgeFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021822/Objectives: To provide contemporary estimates of the prevalence of microcephaly in Europe, determine if the diagnosis of microcephaly is consistent across Europe, and evaluate whether changes in prevalence would be detected using the current European surveillance performed by EUROCAT (the European Surveillance of Congenital Anomalies). Design: Questionnaire and population based observational study. Setting: 24 EUROCAT registries covering 570 000 births annually in 15 countries. Participants: Cases of microcephaly not associated with a genetic condition among live births, fetal deaths from 20 weeks’ gestation, and terminations of pregnancy for fetal anomaly at any gestation. Main: outcome measures Prevalence of microcephaly (1 Jan 2003-31 Dec 2012) analysed with random effects Poisson regression models to account for heterogeneity across registries. Results: 16 registries responded to the questionnaire, of which 44% (7/16) used the EUROCAT definition of microcephaly (a reduction in the size of the brain with a skull circumference more than 3 SD below the mean for sex, age, and ethnic origin), 19% (3/16) used a 2 SD cut off, 31% (5/16) were reliant on the criteria used by individual clinicians, and one changed criteria between 2003 and 2012. Prevalence of microcephaly in Europe was 1.53 (95% confidence interval 1.16 to 1.96) per 10 000 births, with registries varying from 0.4 (0.2 to 0.7) to 4.3 (3.6 to 5.0) per 10 000 (χ2=338, df=23, I2=93%). Registries with a 3 SD cut off reported a prevalence of 1.74 per 10 000 (0.86 to 2.93) compared with those with the less stringent 2 SD cut off of 1.21 per 10 000 (0.21 to 2.93). The prevalence of microcephaly would need to increase in one year by over 35% in Europe or by over 300% in a single registry to reach statistical significance (P<0.01). Conclusions: EUROCAT could detect increases in the prevalence of microcephaly from the Zika virus of a similar magnitude to those observed in Brazil. Because of the rarity of microcephaly and discrepant diagnostic criteria, however, the smaller increases expected in Europe would probably not be detected. Clear diagnostic criteria for microcephaly must be adopted across Europe.This study was funded by the European Union in the framework of the Health Programme (2008-13).BMJ Publishing GroupRepositório Científico do Instituto Nacional de SaúdeMorris, Joan K.Rankin, JudithGarne, EsterLoane, MariaGreenlees, RuthAddor, Marie-ClaudeArriola, LarraitzBarisic, IngeborgBergman, Jorieke E.H.Csaky-Szunyogh, MelindaDias, Carlos MatiasDraper, Elizabeth S.Gatt, MiriamKhoshnood, BabakKlungsoyr, KariKurinczuk, Jennifer J.Lynch, CatherineMcDonnell, RobertNelen, VeraNeville, Amanda J.O'Mahony, Mary T.Pierini, AnnaRandrianaivo, HanitraRissmann, AnkeTucker, DavidVerellen-Dumoulin, Christinede Walle, Hermien E.K.Wellesley, DianaWiesel, AwiDolk, Helen2017-03-03T17:40:47Z2016-09-132016-09-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4464engBMJ. 2016 Sep 13;354:i4721. doi: 10.1136/bmj.i47210959-813810.1136/bmj.i4721info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:19Zoai:repositorio.insa.pt:10400.18/4464Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:11.640063Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Prevalence of microcephaly in Europe: population based study |
| title |
Prevalence of microcephaly in Europe: population based study |
| spellingShingle |
Prevalence of microcephaly in Europe: population based study Morris, Joan K. Microcefalia Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC EUROCAT European Surveillance of Congenital Anomalies European Surveillance Congenital Anomalies Europe |
| title_short |
Prevalence of microcephaly in Europe: population based study |
| title_full |
Prevalence of microcephaly in Europe: population based study |
| title_fullStr |
Prevalence of microcephaly in Europe: population based study |
| title_full_unstemmed |
Prevalence of microcephaly in Europe: population based study |
| title_sort |
Prevalence of microcephaly in Europe: population based study |
| author |
Morris, Joan K. |
| author_facet |
Morris, Joan K. Rankin, Judith Garne, Ester Loane, Maria Greenlees, Ruth Addor, Marie-Claude Arriola, Larraitz Barisic, Ingeborg Bergman, Jorieke E.H. Csaky-Szunyogh, Melinda Dias, Carlos Matias Draper, Elizabeth S. Gatt, Miriam Khoshnood, Babak Klungsoyr, Kari Kurinczuk, Jennifer J. Lynch, Catherine McDonnell, Robert Nelen, Vera Neville, Amanda J. O'Mahony, Mary T. Pierini, Anna Randrianaivo, Hanitra Rissmann, Anke Tucker, David Verellen-Dumoulin, Christine de Walle, Hermien E.K. Wellesley, Diana Wiesel, Awi Dolk, Helen |
| author_role |
author |
| author2 |
Rankin, Judith Garne, Ester Loane, Maria Greenlees, Ruth Addor, Marie-Claude Arriola, Larraitz Barisic, Ingeborg Bergman, Jorieke E.H. Csaky-Szunyogh, Melinda Dias, Carlos Matias Draper, Elizabeth S. Gatt, Miriam Khoshnood, Babak Klungsoyr, Kari Kurinczuk, Jennifer J. Lynch, Catherine McDonnell, Robert Nelen, Vera Neville, Amanda J. O'Mahony, Mary T. Pierini, Anna Randrianaivo, Hanitra Rissmann, Anke Tucker, David Verellen-Dumoulin, Christine de Walle, Hermien E.K. Wellesley, Diana Wiesel, Awi Dolk, Helen |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Morris, Joan K. Rankin, Judith Garne, Ester Loane, Maria Greenlees, Ruth Addor, Marie-Claude Arriola, Larraitz Barisic, Ingeborg Bergman, Jorieke E.H. Csaky-Szunyogh, Melinda Dias, Carlos Matias Draper, Elizabeth S. Gatt, Miriam Khoshnood, Babak Klungsoyr, Kari Kurinczuk, Jennifer J. Lynch, Catherine McDonnell, Robert Nelen, Vera Neville, Amanda J. O'Mahony, Mary T. Pierini, Anna Randrianaivo, Hanitra Rissmann, Anke Tucker, David Verellen-Dumoulin, Christine de Walle, Hermien E.K. Wellesley, Diana Wiesel, Awi Dolk, Helen |
| dc.subject.por.fl_str_mv |
Microcefalia Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC EUROCAT European Surveillance of Congenital Anomalies European Surveillance Congenital Anomalies Europe |
| topic |
Microcefalia Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC EUROCAT European Surveillance of Congenital Anomalies European Surveillance Congenital Anomalies Europe |
| description |
Co-autor: Carlos Matias Dias - Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorge |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-09-13 2016-09-13T00:00:00Z 2017-03-03T17:40:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/4464 |
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http://hdl.handle.net/10400.18/4464 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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BMJ. 2016 Sep 13;354:i4721. doi: 10.1136/bmj.i4721 0959-8138 10.1136/bmj.i4721 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group |
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BMJ Publishing Group |
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