Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review

Detalhes bibliográficos
Autor(a) principal: Alves, Alice
Data de Publicação: 2024
Outros Autores: Fernandes, Catarina, Machado-Neves, Raquel, Ferreira Penêda, José, Vilaça, Marta, van Elzen, Catarina, Martins, Filipa, Lopes, Gustavo, Oliveira, Nuno, Casalta-Lopes, João, Cunha Cabral, Diogo, Vendeira, Lurdes
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34631/sporl.2166
Resumo: Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment.
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spelling Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature reviewCarcinoma neuroendócrino de pequenas células da laringe: um caso clínico e revisão da literaturaCarcinoma neuroendócrino de pequenas célulasCarcinoma da LaringeQuimioradioterapiaSmall Cell Neuroendocrine carcinomaLarynx CarcinomaChemoradiotherapyNeuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment.Os Carcinomas neuroendócrinos (CNE) são tumores raros e heterogéneos em Cabeça e Pescoço (CP) especialmente na laringe, representando menos de 1% dos tumores primários. São classificados em diferentes graus de acordo com a diferenciação celular. O tratamento é multidisciplinar e inclui quimioterapia, cirurgia e radioterapia. Descreve-se o caso clínico de uma paciente de 73 anos com disfonia progressiva e com lesão laríngea. A biópsia histológica da lesão confirmou carcinoma neuroendócrino de pequenas células (CNEPC). A doente foi estadiada como um T3N0M0 e foi submetida a quimioterapia e radioterapia concomitantes. Devido a uma obstrução aguda da via aérea, passou por uma cirurgia a laser de CO2. Após o tratamento com radioterapia (com dose total de 70Gy) e quimioterapia com carboplatino e etoposídeo, a paciente apresentava-se com bom estado geral e sem queixas relacionadas com tratamento. O tratamento do CNEPC geralmente inclui uma abordagem multidisciplinar, no entanto, a taxa de recorrência é elevada, destacando a necessidade de um acompanhamento rigoroso para atuação tão precoce quanto possível, assim como follow-up a longo prazo para avaliar a eficácia do tratamento e a sobrevida dos pacientes. Em conclusão, este caso representa uma patologia rara, diagnosticado num estadio precoce em que foi possível realizar terapêutica com intuito radical graças a uma abordagem multidisciplinar, sem intercorrências major, e até ao momento sem evidência de recidiva.Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2024-09-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.34631/sporl.2166https://doi.org/10.34631/sporl.2166Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 62 No. 3 (2024): September; 295-301Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 62 Núm. 3 (2024): Setembro; 295-301Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 62 N.º 3 (2024): Setembro; 295-3012184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://journalsporl.com/index.php/sporl/article/view/2166https://journalsporl.com/index.php/sporl/article/view/2166/1131https://journalsporl.com/index.php/sporl/article/view/2166/1132Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessAlves, AliceFernandes, CatarinaMachado-Neves, RaquelFerreira Penêda, JoséVilaça, Martavan Elzen, CatarinaMartins, FilipaLopes, GustavoOliveira, NunoCasalta-Lopes, JoãoCunha Cabral, DiogoVendeira, Lurdes2024-09-26T13:22:18Zoai:journalsporl.com:article/2166Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T13:22:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
Carcinoma neuroendócrino de pequenas células da laringe: um caso clínico e revisão da literatura
title Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
spellingShingle Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
Alves, Alice
Carcinoma neuroendócrino de pequenas células
Carcinoma da Laringe
Quimioradioterapia
Small Cell Neuroendocrine carcinoma
Larynx Carcinoma
Chemoradiotherapy
title_short Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
title_full Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
title_fullStr Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
title_full_unstemmed Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
title_sort Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
author Alves, Alice
author_facet Alves, Alice
Fernandes, Catarina
Machado-Neves, Raquel
Ferreira Penêda, José
Vilaça, Marta
van Elzen, Catarina
Martins, Filipa
Lopes, Gustavo
Oliveira, Nuno
Casalta-Lopes, João
Cunha Cabral, Diogo
Vendeira, Lurdes
author_role author
author2 Fernandes, Catarina
Machado-Neves, Raquel
Ferreira Penêda, José
Vilaça, Marta
van Elzen, Catarina
Martins, Filipa
Lopes, Gustavo
Oliveira, Nuno
Casalta-Lopes, João
Cunha Cabral, Diogo
Vendeira, Lurdes
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Alice
Fernandes, Catarina
Machado-Neves, Raquel
Ferreira Penêda, José
Vilaça, Marta
van Elzen, Catarina
Martins, Filipa
Lopes, Gustavo
Oliveira, Nuno
Casalta-Lopes, João
Cunha Cabral, Diogo
Vendeira, Lurdes
dc.subject.por.fl_str_mv Carcinoma neuroendócrino de pequenas células
Carcinoma da Laringe
Quimioradioterapia
Small Cell Neuroendocrine carcinoma
Larynx Carcinoma
Chemoradiotherapy
topic Carcinoma neuroendócrino de pequenas células
Carcinoma da Laringe
Quimioradioterapia
Small Cell Neuroendocrine carcinoma
Larynx Carcinoma
Chemoradiotherapy
description Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment.
publishDate 2024
dc.date.none.fl_str_mv 2024-09-21
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.34631/sporl.2166
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url https://doi.org/10.34631/sporl.2166
dc.language.iso.fl_str_mv eng
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language eng
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https://journalsporl.com/index.php/sporl/article/view/2166/1131
https://journalsporl.com/index.php/sporl/article/view/2166/1132
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.source.none.fl_str_mv Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 62 No. 3 (2024): September; 295-301
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 62 Núm. 3 (2024): Setembro; 295-301
Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 62 N.º 3 (2024): Setembro; 295-301
2184-6499
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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