Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34631/sporl.2166 |
Resumo: | Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment. |
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Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature reviewCarcinoma neuroendócrino de pequenas células da laringe: um caso clínico e revisão da literaturaCarcinoma neuroendócrino de pequenas célulasCarcinoma da LaringeQuimioradioterapiaSmall Cell Neuroendocrine carcinomaLarynx CarcinomaChemoradiotherapyNeuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment.Os Carcinomas neuroendócrinos (CNE) são tumores raros e heterogéneos em Cabeça e Pescoço (CP) especialmente na laringe, representando menos de 1% dos tumores primários. São classificados em diferentes graus de acordo com a diferenciação celular. O tratamento é multidisciplinar e inclui quimioterapia, cirurgia e radioterapia. Descreve-se o caso clínico de uma paciente de 73 anos com disfonia progressiva e com lesão laríngea. A biópsia histológica da lesão confirmou carcinoma neuroendócrino de pequenas células (CNEPC). A doente foi estadiada como um T3N0M0 e foi submetida a quimioterapia e radioterapia concomitantes. Devido a uma obstrução aguda da via aérea, passou por uma cirurgia a laser de CO2. Após o tratamento com radioterapia (com dose total de 70Gy) e quimioterapia com carboplatino e etoposídeo, a paciente apresentava-se com bom estado geral e sem queixas relacionadas com tratamento. O tratamento do CNEPC geralmente inclui uma abordagem multidisciplinar, no entanto, a taxa de recorrência é elevada, destacando a necessidade de um acompanhamento rigoroso para atuação tão precoce quanto possível, assim como follow-up a longo prazo para avaliar a eficácia do tratamento e a sobrevida dos pacientes. Em conclusão, este caso representa uma patologia rara, diagnosticado num estadio precoce em que foi possível realizar terapêutica com intuito radical graças a uma abordagem multidisciplinar, sem intercorrências major, e até ao momento sem evidência de recidiva.Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2024-09-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.34631/sporl.2166https://doi.org/10.34631/sporl.2166Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 62 No. 3 (2024): September; 295-301Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 62 Núm. 3 (2024): Setembro; 295-301Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 62 N.º 3 (2024): Setembro; 295-3012184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://journalsporl.com/index.php/sporl/article/view/2166https://journalsporl.com/index.php/sporl/article/view/2166/1131https://journalsporl.com/index.php/sporl/article/view/2166/1132Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessAlves, AliceFernandes, CatarinaMachado-Neves, RaquelFerreira Penêda, JoséVilaça, Martavan Elzen, CatarinaMartins, FilipaLopes, GustavoOliveira, NunoCasalta-Lopes, JoãoCunha Cabral, DiogoVendeira, Lurdes2024-09-26T13:22:18Zoai:journalsporl.com:article/2166Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T13:22:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review Carcinoma neuroendócrino de pequenas células da laringe: um caso clínico e revisão da literatura |
title |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
spellingShingle |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review Alves, Alice Carcinoma neuroendócrino de pequenas células Carcinoma da Laringe Quimioradioterapia Small Cell Neuroendocrine carcinoma Larynx Carcinoma Chemoradiotherapy |
title_short |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
title_full |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
title_fullStr |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
title_full_unstemmed |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
title_sort |
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literature review |
author |
Alves, Alice |
author_facet |
Alves, Alice Fernandes, Catarina Machado-Neves, Raquel Ferreira Penêda, José Vilaça, Marta van Elzen, Catarina Martins, Filipa Lopes, Gustavo Oliveira, Nuno Casalta-Lopes, João Cunha Cabral, Diogo Vendeira, Lurdes |
author_role |
author |
author2 |
Fernandes, Catarina Machado-Neves, Raquel Ferreira Penêda, José Vilaça, Marta van Elzen, Catarina Martins, Filipa Lopes, Gustavo Oliveira, Nuno Casalta-Lopes, João Cunha Cabral, Diogo Vendeira, Lurdes |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Alves, Alice Fernandes, Catarina Machado-Neves, Raquel Ferreira Penêda, José Vilaça, Marta van Elzen, Catarina Martins, Filipa Lopes, Gustavo Oliveira, Nuno Casalta-Lopes, João Cunha Cabral, Diogo Vendeira, Lurdes |
dc.subject.por.fl_str_mv |
Carcinoma neuroendócrino de pequenas células Carcinoma da Laringe Quimioradioterapia Small Cell Neuroendocrine carcinoma Larynx Carcinoma Chemoradiotherapy |
topic |
Carcinoma neuroendócrino de pequenas células Carcinoma da Laringe Quimioradioterapia Small Cell Neuroendocrine carcinoma Larynx Carcinoma Chemoradiotherapy |
description |
Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-09-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34631/sporl.2166 https://doi.org/10.34631/sporl.2166 |
url |
https://doi.org/10.34631/sporl.2166 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://journalsporl.com/index.php/sporl/article/view/2166 https://journalsporl.com/index.php/sporl/article/view/2166/1131 https://journalsporl.com/index.php/sporl/article/view/2166/1132 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2024 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
dc.source.none.fl_str_mv |
Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 62 No. 3 (2024): September; 295-301 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 62 Núm. 3 (2024): Setembro; 295-301 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 62 N.º 3 (2024): Setembro; 295-301 2184-6499 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817547216018997248 |