Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/3168 |
Resumo: | Acute hepatitis results from oxidative stress triggered by hepatotoxic drugs causing liver injury and the activation of caspases cascade. The glutathione antioxidant system protects against reactive oxygen species and mitigates development of these processes. The effectiveness of silymarin, a polyphenolic flavonoid, essenthiale, composed of phosphatidyl choline, and melaxen, a melatonin-correcting drug, as hepatoprotectors has been investigated. The variation of 6-sulfatoxymelatonin (aMT6s), resulting from the biotransformation of melatonin, and GSH has been measured. The activities of caspase-1 and caspase-3, glutathione antioxidant system, and NADPH-generating enzymes were determined. The aMT6s decreases in patients with drug hepatitis and recovers with administration of mexalen. GSH increased in the presence of the studied hepatoprotectors. Pathologically activated caspase-1 and caspase-3 decreased their activities in the presence of hepatoprotectors with melaxen showing the highest effect. The positive effect of melatonin appears to be related to the suppression of decompensation of the glutathione antioxidant system functions, recovery of liver redox status, and the attenuation of inhibition of the NADPH supply. |
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Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protectionDrug-induced hepatitisGlutathione antioxidant system6-SulfatoxymelatoninReduced gluthationeHepatoprotectors.Faculdade de Ciências da VidaAcute hepatitis results from oxidative stress triggered by hepatotoxic drugs causing liver injury and the activation of caspases cascade. The glutathione antioxidant system protects against reactive oxygen species and mitigates development of these processes. The effectiveness of silymarin, a polyphenolic flavonoid, essenthiale, composed of phosphatidyl choline, and melaxen, a melatonin-correcting drug, as hepatoprotectors has been investigated. The variation of 6-sulfatoxymelatonin (aMT6s), resulting from the biotransformation of melatonin, and GSH has been measured. The activities of caspase-1 and caspase-3, glutathione antioxidant system, and NADPH-generating enzymes were determined. The aMT6s decreases in patients with drug hepatitis and recovers with administration of mexalen. GSH increased in the presence of the studied hepatoprotectors. Pathologically activated caspase-1 and caspase-3 decreased their activities in the presence of hepatoprotectors with melaxen showing the highest effect. The positive effect of melatonin appears to be related to the suppression of decompensation of the glutathione antioxidant system functions, recovery of liver redox status, and the attenuation of inhibition of the NADPH supply.This work was supported by grant of the President of the Russian Federation for young scientists MK- 3133.2011.7. Authors thank to President of Voronezh State Medical Academy named after N. N. Burdenko (Russia), Prof. Igor E. Esaulenko, for advice and suggestions.WileyDigitUMaPopov, Serguey S.Shulgin, Konstantin K.Popova, Tatyana N.Pashkov, Aleksander N.Agarkov, Aleksander A.Carvalho, Miguel A. A. Pinheiro de2021-03-15T09:51:40Z2015-01-01T00:00:00Z2015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3168engPopov, S. S., Shulgin, K. K., Popova, T. N., Pashkov, A. N., Agarkov, A. A., & Carvalho, M. A. P. (2015). Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection. Journal of biochemical and molecular toxicology, 29(10), 449-457. https://doi.org/10.1002/jbt.2170510.1002/jbt.21705info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:56:05ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
title |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
spellingShingle |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection Popov, Serguey S. Drug-induced hepatitis Glutathione antioxidant system 6-Sulfatoxymelatonin Reduced gluthatione Hepatoprotectors . Faculdade de Ciências da Vida |
title_short |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
title_full |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
title_fullStr |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
title_full_unstemmed |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
title_sort |
Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection |
author |
Popov, Serguey S. |
author_facet |
Popov, Serguey S. Shulgin, Konstantin K. Popova, Tatyana N. Pashkov, Aleksander N. Agarkov, Aleksander A. Carvalho, Miguel A. A. Pinheiro de |
author_role |
author |
author2 |
Shulgin, Konstantin K. Popova, Tatyana N. Pashkov, Aleksander N. Agarkov, Aleksander A. Carvalho, Miguel A. A. Pinheiro de |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Popov, Serguey S. Shulgin, Konstantin K. Popova, Tatyana N. Pashkov, Aleksander N. Agarkov, Aleksander A. Carvalho, Miguel A. A. Pinheiro de |
dc.subject.por.fl_str_mv |
Drug-induced hepatitis Glutathione antioxidant system 6-Sulfatoxymelatonin Reduced gluthatione Hepatoprotectors . Faculdade de Ciências da Vida |
topic |
Drug-induced hepatitis Glutathione antioxidant system 6-Sulfatoxymelatonin Reduced gluthatione Hepatoprotectors . Faculdade de Ciências da Vida |
description |
Acute hepatitis results from oxidative stress triggered by hepatotoxic drugs causing liver injury and the activation of caspases cascade. The glutathione antioxidant system protects against reactive oxygen species and mitigates development of these processes. The effectiveness of silymarin, a polyphenolic flavonoid, essenthiale, composed of phosphatidyl choline, and melaxen, a melatonin-correcting drug, as hepatoprotectors has been investigated. The variation of 6-sulfatoxymelatonin (aMT6s), resulting from the biotransformation of melatonin, and GSH has been measured. The activities of caspase-1 and caspase-3, glutathione antioxidant system, and NADPH-generating enzymes were determined. The aMT6s decreases in patients with drug hepatitis and recovers with administration of mexalen. GSH increased in the presence of the studied hepatoprotectors. Pathologically activated caspase-1 and caspase-3 decreased their activities in the presence of hepatoprotectors with melaxen showing the highest effect. The positive effect of melatonin appears to be related to the suppression of decompensation of the glutathione antioxidant system functions, recovery of liver redox status, and the attenuation of inhibition of the NADPH supply. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01T00:00:00Z 2015-01-01T00:00:00Z 2021-03-15T09:51:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/3168 |
url |
http://hdl.handle.net/10400.13/3168 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Popov, S. S., Shulgin, K. K., Popova, T. N., Pashkov, A. N., Agarkov, A. A., & Carvalho, M. A. P. (2015). Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection. Journal of biochemical and molecular toxicology, 29(10), 449-457. https://doi.org/10.1002/jbt.21705 10.1002/jbt.21705 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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