Uma nova abordagem de cancro baseada na teoria das células estaminais
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/11855 |
Resumo: | Stem cells are being intensively studied because, in addition to therapeutic weapons, they can also be targets in treatment strategies of many diseases, namely in cancer, where they have an important etiologic role. Classical regulatory pathways of stem cells are deregulated in several tumours, strengthening the role of these cells in the carcinogenesis process. The mammary gland is a good model for studying carcinogenesis because of its unique anatomic, functional and pathologic characteristics. There are several exceptional experimental models used in etiologic, pathophysiologic, diagnostic and therapeutic research in cancer using this complex organ. After isolation of tumoural stem cells in the haematopoietic system, the breast and brain were the organs whose solid tumours were studied in order to isolate stem cells. In this article, a monoclonal theory of cancer is presented, supported by the stem cell theory and by extensive experimental work. Stem cells mutations would be in the origin of the most aggressive and undifferentiated tumors, whereas tumours with better prognosis would be originated in more differentiated progenitor cells. The higher aggressiveness of the former could be explained by expression of MDR proteins in stem cells. The protective role of pregnancy in breast cancer, would in the light of the exposed theory, be explained by the inhibitory influences of differentiated tissue. The isolation of tumour stem cells, combined with profound knowledge of cancer regulatory pathways, may lead us to develop, in the short future, specific therapeutic strategies that could transform cancer into a treatable or chronic disease. |
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Uma nova abordagem de cancro baseada na teoria das células estaminaisNew insights on cancer based on the stem cells theoryStem cells are being intensively studied because, in addition to therapeutic weapons, they can also be targets in treatment strategies of many diseases, namely in cancer, where they have an important etiologic role. Classical regulatory pathways of stem cells are deregulated in several tumours, strengthening the role of these cells in the carcinogenesis process. The mammary gland is a good model for studying carcinogenesis because of its unique anatomic, functional and pathologic characteristics. There are several exceptional experimental models used in etiologic, pathophysiologic, diagnostic and therapeutic research in cancer using this complex organ. After isolation of tumoural stem cells in the haematopoietic system, the breast and brain were the organs whose solid tumours were studied in order to isolate stem cells. In this article, a monoclonal theory of cancer is presented, supported by the stem cell theory and by extensive experimental work. Stem cells mutations would be in the origin of the most aggressive and undifferentiated tumors, whereas tumours with better prognosis would be originated in more differentiated progenitor cells. The higher aggressiveness of the former could be explained by expression of MDR proteins in stem cells. The protective role of pregnancy in breast cancer, would in the light of the exposed theory, be explained by the inhibitory influences of differentiated tissue. The isolation of tumour stem cells, combined with profound knowledge of cancer regulatory pathways, may lead us to develop, in the short future, specific therapeutic strategies that could transform cancer into a treatable or chronic disease.Federação das Sociedades Portuguesas de Obstetrícia e Ginecologia2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/11855http://hdl.handle.net/10316/11855porActa Obstétrica e Ginecológica Portuguesa. 3:1 (2009) 45-531646-5830Martins, FilipeBotelho, MariaCabrita, AntónioFreire-de-Oliveira, Carlosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T10:19:32Zoai:estudogeral.uc.pt:10316/11855Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:43.230252Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Uma nova abordagem de cancro baseada na teoria das células estaminais New insights on cancer based on the stem cells theory |
title |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
spellingShingle |
Uma nova abordagem de cancro baseada na teoria das células estaminais Martins, Filipe |
title_short |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
title_full |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
title_fullStr |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
title_full_unstemmed |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
title_sort |
Uma nova abordagem de cancro baseada na teoria das células estaminais |
author |
Martins, Filipe |
author_facet |
Martins, Filipe Botelho, Maria Cabrita, António Freire-de-Oliveira, Carlos |
author_role |
author |
author2 |
Botelho, Maria Cabrita, António Freire-de-Oliveira, Carlos |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Martins, Filipe Botelho, Maria Cabrita, António Freire-de-Oliveira, Carlos |
description |
Stem cells are being intensively studied because, in addition to therapeutic weapons, they can also be targets in treatment strategies of many diseases, namely in cancer, where they have an important etiologic role. Classical regulatory pathways of stem cells are deregulated in several tumours, strengthening the role of these cells in the carcinogenesis process. The mammary gland is a good model for studying carcinogenesis because of its unique anatomic, functional and pathologic characteristics. There are several exceptional experimental models used in etiologic, pathophysiologic, diagnostic and therapeutic research in cancer using this complex organ. After isolation of tumoural stem cells in the haematopoietic system, the breast and brain were the organs whose solid tumours were studied in order to isolate stem cells. In this article, a monoclonal theory of cancer is presented, supported by the stem cell theory and by extensive experimental work. Stem cells mutations would be in the origin of the most aggressive and undifferentiated tumors, whereas tumours with better prognosis would be originated in more differentiated progenitor cells. The higher aggressiveness of the former could be explained by expression of MDR proteins in stem cells. The protective role of pregnancy in breast cancer, would in the light of the exposed theory, be explained by the inhibitory influences of differentiated tissue. The isolation of tumour stem cells, combined with profound knowledge of cancer regulatory pathways, may lead us to develop, in the short future, specific therapeutic strategies that could transform cancer into a treatable or chronic disease. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/11855 http://hdl.handle.net/10316/11855 |
url |
http://hdl.handle.net/10316/11855 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Acta Obstétrica e Ginecológica Portuguesa. 3:1 (2009) 45-53 1646-5830 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Federação das Sociedades Portuguesas de Obstetrícia e Ginecologia |
publisher.none.fl_str_mv |
Federação das Sociedades Portuguesas de Obstetrícia e Ginecologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133709440385024 |