Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/119294 |
Resumo: | Damage to peripheral nerve fibers results in axonal loss and demyelination followed by regeneration and remyelination under optimal conditions with the possibility of some functional recovery. The experimental challenge is to accelerate axonal regeneration to promote reinnervation and improve functional recovery after peripheral nerve injury. In the past few decades, different types of biological or artificial guide tubes have been developed to bridge the gap of a sectioned nerve, to limit the fibrosis process and to orient the regenerating fibers towards the distal stump. Chitosan is widely used for biomedical applications, including crosslinked with other materials. In this work, chitosan guide tubes were produced and implanted using the rat sciatic nerve animal model. Functional tests were performed as well as a mechanical and structural characterization of the guide tubes. (c) 2017 IEEE. |
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Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymerDamage to peripheral nerve fibers results in axonal loss and demyelination followed by regeneration and remyelination under optimal conditions with the possibility of some functional recovery. The experimental challenge is to accelerate axonal regeneration to promote reinnervation and improve functional recovery after peripheral nerve injury. In the past few decades, different types of biological or artificial guide tubes have been developed to bridge the gap of a sectioned nerve, to limit the fibrosis process and to orient the regenerating fibers towards the distal stump. Chitosan is widely used for biomedical applications, including crosslinked with other materials. In this work, chitosan guide tubes were produced and implanted using the rat sciatic nerve animal model. Functional tests were performed as well as a mechanical and structural characterization of the guide tubes. (c) 2017 IEEE.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://hdl.handle.net/10216/119294eng10.1109/enbeng.2017.7889482Gomes, JSantos, JDMauricio, ACinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:57:50Zoai:repositorio-aberto.up.pt:10216/119294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:12:35.546197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
title |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
spellingShingle |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer Gomes, J |
title_short |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
title_full |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
title_fullStr |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
title_full_unstemmed |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
title_sort |
Regeneration of the peripheral nerve - Development and evaluation of guide tubes of biodegradable polymer |
author |
Gomes, J |
author_facet |
Gomes, J Santos, JD Mauricio, AC |
author_role |
author |
author2 |
Santos, JD Mauricio, AC |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gomes, J Santos, JD Mauricio, AC |
description |
Damage to peripheral nerve fibers results in axonal loss and demyelination followed by regeneration and remyelination under optimal conditions with the possibility of some functional recovery. The experimental challenge is to accelerate axonal regeneration to promote reinnervation and improve functional recovery after peripheral nerve injury. In the past few decades, different types of biological or artificial guide tubes have been developed to bridge the gap of a sectioned nerve, to limit the fibrosis process and to orient the regenerating fibers towards the distal stump. Chitosan is widely used for biomedical applications, including crosslinked with other materials. In this work, chitosan guide tubes were produced and implanted using the rat sciatic nerve animal model. Functional tests were performed as well as a mechanical and structural characterization of the guide tubes. (c) 2017 IEEE. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/119294 |
url |
https://hdl.handle.net/10216/119294 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1109/enbeng.2017.7889482 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136048057417728 |