ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study

Detalhes bibliográficos
Autor(a) principal: Ferreira, Joana
Data de Publicação: 2022
Outros Autores: Bicho, Manuel, Serejo, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/60546
Resumo: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary studyATP binding cassette transporter A1Chronic hepatitis CFibrosisGenetic polymorphism© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Chronic hepatitis C (CHC) progression is highly variable and can be influenced by lipid metabolism. The ATP-binding cassette transporter A1 (ABCA1) is involved in lipid metabolism and mediates cholesterol efflux from liver cells. ABCA1 gene polymorphism rs2230808 (R1587K) modulates lipid levels as it is located in an ABCA1 protein domain, which is essential for cholesterol efflux. We aimed to analyze the role of ABCA1 polymorphism R1587K (rs2230808) in modulating the biochemical parameters of lipid metabolism and liver function and its association with liver disease severity, according to gender. A total of 161 CHC patients were clinically, histologically, and biochemically evaluated. Genotyping was performed by melting-curve analysis and statistical analysis by SPSS 24.0. There were significant differences between ABCA1_rs2230808 genotypes and total cholesterol, γGT (γ-glutamyl-transpeptidase), and HCV-RNA. Gender differences: in females, ABCA1_rs2230808 (GG or GA) was associated with higher HCV-RNA serum levels; in males, ABCA1_rs2230808 (GG or GA) was associated with higher γGT, lower total cholesterol, increased risk for γGT ≥ 38 UI/L, and total cholesterol < 4.92 mmol/L. Only in the case of males were higher γGT and lower total cholesterol associated with severe fibrosis and steatosis. Total cholesterol < 4.92 mmol/L also associates with severe necroinflammation. We conclude that ABCA1_rs2230808 is gender-specific. ABCA1_rs2230808 Allele G was associated with different clinical and biochemical parameters, which are related to more severe liver disease.Ph.D. scholarship from Technology and Science Foundation (FCT); PDE/BDE/114585/2016. The writing of the manuscript was also supported by funds from the Foundation for Science and Technology to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020).MDPIRepositório da Universidade de LisboaFerreira, JoanaBicho, ManuelSerejo, Fátima2023-11-14T16:23:46Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/60546engGenes (Basel). 2022 Nov 11;13(11):209510.3390/genes131120952073-4425info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:25:01Zoai:repositorio.ul.pt:10451/60546Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:25:01Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
title ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
spellingShingle ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
Ferreira, Joana
ATP binding cassette transporter A1
Chronic hepatitis C
Fibrosis
Genetic polymorphism
title_short ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
title_full ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
title_fullStr ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
title_full_unstemmed ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
title_sort ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
author Ferreira, Joana
author_facet Ferreira, Joana
Bicho, Manuel
Serejo, Fátima
author_role author
author2 Bicho, Manuel
Serejo, Fátima
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ferreira, Joana
Bicho, Manuel
Serejo, Fátima
dc.subject.por.fl_str_mv ATP binding cassette transporter A1
Chronic hepatitis C
Fibrosis
Genetic polymorphism
topic ATP binding cassette transporter A1
Chronic hepatitis C
Fibrosis
Genetic polymorphism
description © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-11-14T16:23:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/60546
url http://hdl.handle.net/10451/60546
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genes (Basel). 2022 Nov 11;13(11):2095
10.3390/genes13112095
2073-4425
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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