Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites

Detalhes bibliográficos
Autor(a) principal: Vassal, Mariana
Data de Publicação: 2019
Outros Autores: Pereira, J. Nunes, Miguel, Sónia, Correia, Ilidio, Silva, Abilio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/6897
Resumo: The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.
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spelling Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocompositesHydroxyapatiteCalcium zirconateCeramic biocompositesMechanical propertiesBioactivityThe biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.ElsevieruBibliorumVassal, MarianaPereira, J. NunesMiguel, SóniaCorreia, IlidioSilva, Abilio2022-03-08T01:30:16Z2019-01-252019-01-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/6897eng10.1016/j.ceramint.2019.01.122info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:21:50Zoai:ubibliorum.ubi.pt:10400.6/6897Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:21:50Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
title Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
spellingShingle Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
Vassal, Mariana
Hydroxyapatite
Calcium zirconate
Ceramic biocomposites
Mechanical properties
Bioactivity
title_short Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
title_full Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
title_fullStr Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
title_full_unstemmed Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
title_sort Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
author Vassal, Mariana
author_facet Vassal, Mariana
Pereira, J. Nunes
Miguel, Sónia
Correia, Ilidio
Silva, Abilio
author_role author
author2 Pereira, J. Nunes
Miguel, Sónia
Correia, Ilidio
Silva, Abilio
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Vassal, Mariana
Pereira, J. Nunes
Miguel, Sónia
Correia, Ilidio
Silva, Abilio
dc.subject.por.fl_str_mv Hydroxyapatite
Calcium zirconate
Ceramic biocomposites
Mechanical properties
Bioactivity
topic Hydroxyapatite
Calcium zirconate
Ceramic biocomposites
Mechanical properties
Bioactivity
description The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-25
2019-01-25T00:00:00Z
2022-03-08T01:30:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/6897
url http://hdl.handle.net/10400.6/6897
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.ceramint.2019.01.122
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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