Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/6897 |
Resumo: | The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocompositesHydroxyapatiteCalcium zirconateCeramic biocompositesMechanical propertiesBioactivityThe biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.ElsevieruBibliorumVassal, MarianaPereira, J. NunesMiguel, SóniaCorreia, IlidioSilva, Abilio2022-03-08T01:30:16Z2019-01-252019-01-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/6897eng10.1016/j.ceramint.2019.01.122info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:21:50Zoai:ubibliorum.ubi.pt:10400.6/6897Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:21:50Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
title |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
spellingShingle |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites Vassal, Mariana Hydroxyapatite Calcium zirconate Ceramic biocomposites Mechanical properties Bioactivity |
title_short |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
title_full |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
title_fullStr |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
title_full_unstemmed |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
title_sort |
Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
author |
Vassal, Mariana |
author_facet |
Vassal, Mariana Pereira, J. Nunes Miguel, Sónia Correia, Ilidio Silva, Abilio |
author_role |
author |
author2 |
Pereira, J. Nunes Miguel, Sónia Correia, Ilidio Silva, Abilio |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Vassal, Mariana Pereira, J. Nunes Miguel, Sónia Correia, Ilidio Silva, Abilio |
dc.subject.por.fl_str_mv |
Hydroxyapatite Calcium zirconate Ceramic biocomposites Mechanical properties Bioactivity |
topic |
Hydroxyapatite Calcium zirconate Ceramic biocomposites Mechanical properties Bioactivity |
description |
The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-25 2019-01-25T00:00:00Z 2022-03-08T01:30:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/6897 |
url |
http://hdl.handle.net/10400.6/6897 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.ceramint.2019.01.122 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817549622922444800 |