Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/125817 |
Resumo: | the agreement number ERC-2016-CoG 725034 (ERC Consolidator PTDC/EQU-EQU/29851/2017 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservationCytotoxicityGlucoseNADESProlineThermal propertiesUreaWater mixturesElectronic, Optical and Magnetic MaterialsAtomic and Molecular Physics, and OpticsCondensed Matter PhysicsSpectroscopyPhysical and Theoretical ChemistryMaterials Chemistrythe agreement number ERC-2016-CoG 725034 (ERC Consolidator PTDC/EQU-EQU/29851/2017Natural deep eutectic systems (NADES), which have applications as solvents for both engineering and life sciences, are mainly composed of sugars, aminoacids or organic acids. In this work NADES composed by glucose, urea and proline (G:U:P in a molar ratio of 1:1:1) and proline and glucose (P:G 5:3) were prepared and added in different mass fractions to water. By differential scanning calorimetry it was verified as the crystallization tendency of water is modified even for low fraction of NADES added. This is also observed by polarized optical microscopy which allowed following the formation of crystals with different crystalline morphologies as bulk water. Calorimetric data also shown as the crystallization temperature decreases for all P:G mixtures and this shift is more accentuated for weight fraction of NADES higher than 0.5. Crystallization is totally suppressed for NADES fraction higher than 0.7. NADES/water mixtures cytotoxicity was evaluated in vitro, revealing that they are less toxic as compared with the commonly used cryoprotective additives as dimethyl sulfoxide (DMSO). Additionally, cell viability tests with cell lines cryopreserved using DMSO and both the prepared NADES showed comparable viability. This work combines thermophysical data on NADES and evaluates it's in vitro performance, providing cues for their use in cryopreservation applications.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNCraveiro, RitaCastro, Vânia I. B.Viciosa, Maria TeresaDionísio, MadalenaReis, R. L.Duarte, Ana Rita C.Paiva, Alexandre2021-10-09T04:55:36Z2021-05-012021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/125817eng0167-7322PURE: 28466706https://doi.org/10.1016/j.molliq.2021.115533info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:56:35Zoai:run.unl.pt:10362/125817Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:56:35Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| title |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| spellingShingle |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation Craveiro, Rita Cytotoxicity Glucose NADES Proline Thermal properties Urea Water mixtures Electronic, Optical and Magnetic Materials Atomic and Molecular Physics, and Optics Condensed Matter Physics Spectroscopy Physical and Theoretical Chemistry Materials Chemistry |
| title_short |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| title_full |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| title_fullStr |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| title_full_unstemmed |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| title_sort |
Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation |
| author |
Craveiro, Rita |
| author_facet |
Craveiro, Rita Castro, Vânia I. B. Viciosa, Maria Teresa Dionísio, Madalena Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
| author_role |
author |
| author2 |
Castro, Vânia I. B. Viciosa, Maria Teresa Dionísio, Madalena Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Craveiro, Rita Castro, Vânia I. B. Viciosa, Maria Teresa Dionísio, Madalena Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
| dc.subject.por.fl_str_mv |
Cytotoxicity Glucose NADES Proline Thermal properties Urea Water mixtures Electronic, Optical and Magnetic Materials Atomic and Molecular Physics, and Optics Condensed Matter Physics Spectroscopy Physical and Theoretical Chemistry Materials Chemistry |
| topic |
Cytotoxicity Glucose NADES Proline Thermal properties Urea Water mixtures Electronic, Optical and Magnetic Materials Atomic and Molecular Physics, and Optics Condensed Matter Physics Spectroscopy Physical and Theoretical Chemistry Materials Chemistry |
| description |
the agreement number ERC-2016-CoG 725034 (ERC Consolidator PTDC/EQU-EQU/29851/2017 |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-10-09T04:55:36Z 2021-05-01 2021-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/125817 |
| url |
http://hdl.handle.net/10362/125817 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0167-7322 PURE: 28466706 https://doi.org/10.1016/j.molliq.2021.115533 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
| _version_ |
1817545824678182912 |