Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo

Detalhes bibliográficos
Autor(a) principal: Nunes, Márcia Cláudia Guimarães
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56135
Resumo: Tese de mestrado integrado, Engenharia Biomédica e Biofísica, 2022, Universidade de Lisboa, Faculdade de Ciências
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spelling Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivopipelineplasticidade da mielinacamadas corticaisin vivoressonância magnética de campo ultra-altoTeses de mestrado - 2022Departamento de FísicaTese de mestrado integrado, Engenharia Biomédica e Biofísica, 2022, Universidade de Lisboa, Faculdade de CiênciasThe ventral occipital-temporal cortex (VOTC) is a high-level area in the visual cortex where specific regions are exclusively category-selective for certain visual stimuli. Some studies have demonstrated that absence of visual experience can reshape this functional architecture. In particular, they demonstrated that crossmodal plasticity due to blindness causes a remodeling of the category topographic map in response to auditory stimuli, reflecting closely the visual category topographic map in the sighted population. To our knowledge, it has not yet been investigated if this topographic map remodeling in the absence of bottom-up visual inputs during development is also reflected in the myelin distribution laminar profile within VOTC regions. Nowadays, advancements in neuroimaging techniques allow the mesoscale (submillimeter) in vivo myelin profiling using quantitative markers and 7T ultra-high field (UHF) magnetic resonance imaging (MRI). The aim of this dissertation is to select the MRI sequence available in the 7T MRI at the Cyclotron Research Center (ULiège) that would best allow the quantification of myelin density in the VOTC of sighted and blind individuals and to develop an open-source pipeline to characterize the myelin laminar distribution in the regions of interest in both groups. The assessment of noise and variability between scans demonstrated that compared to the multiparametric mapping sequences, MP2RAGE provides quantitative and reproducible high-resolution myelin maps. The myelin laminar profiles obtained in the regions of interest are in line with previous ex vivo and in vivo studies, demonstrating that MP2RAGE is a measure allowing myelin cortical profiling in VOTC with faster data acquisition. The pipeline here developed corresponds to the first stages of the above-mentioned project and will allow in the future comparative studies of the cortical laminar organization between the blind and sighted populations, improving our understanding about the role of crossmodal plasticity in reshaping cortex microstructure.Andrade, Alexandre da Rocha Freire de, 1971-Collignon, OlivierRepositório da Universidade de LisboaNunes, Márcia Cláudia Guimarães2023-02-03T11:45:46Z202220222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/56135enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:31Zoai:repositorio.ul.pt:10451/56135Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:40.825808Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
title Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
spellingShingle Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
Nunes, Márcia Cláudia Guimarães
pipeline
plasticidade da mielina
camadas corticais
in vivo
ressonância magnética de campo ultra-alto
Teses de mestrado - 2022
Departamento de Física
title_short Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
title_full Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
title_fullStr Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
title_full_unstemmed Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
title_sort Building an analysis pipeline to explore at ultra-high field (7T) MRI the laminar distribution of myelin in the human cortex in vivo
author Nunes, Márcia Cláudia Guimarães
author_facet Nunes, Márcia Cláudia Guimarães
author_role author
dc.contributor.none.fl_str_mv Andrade, Alexandre da Rocha Freire de, 1971-
Collignon, Olivier
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Nunes, Márcia Cláudia Guimarães
dc.subject.por.fl_str_mv pipeline
plasticidade da mielina
camadas corticais
in vivo
ressonância magnética de campo ultra-alto
Teses de mestrado - 2022
Departamento de Física
topic pipeline
plasticidade da mielina
camadas corticais
in vivo
ressonância magnética de campo ultra-alto
Teses de mestrado - 2022
Departamento de Física
description Tese de mestrado integrado, Engenharia Biomédica e Biofísica, 2022, Universidade de Lisboa, Faculdade de Ciências
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022-01-01T00:00:00Z
2023-02-03T11:45:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56135
url http://hdl.handle.net/10451/56135
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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