Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines

Detalhes bibliográficos
Autor(a) principal: Durão, Vera
Data de Publicação: 2018
Outros Autores: Silva, Anabela, Macedo, Rita, Durão, Paulo, Santos-Silva, André, Duarte, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6271
Resumo: Supplementary material associated with this article can be found in the online version available at doi:10.1016/j.pulmoe.2018.09.001.
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spelling Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelinesAntibiotic ResistanceAntimicrobial TreatmentDrug Susceptibility TestingNontuberculous mycobacteriaInfecções GastrointestinaisSupplementary material associated with this article can be found in the online version available at doi:10.1016/j.pulmoe.2018.09.001.Setting: Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is, however, very little information on the prevalence of NTM drug resistance in Portugal. Objective and Design: Our aim was to analyze the drug susceptibility testing (DST) performed in NTM at the Portuguese National Health Institute Dr. Ricardo Jorge from February 2003 to February 2016. A total of 262 DST were included in the analysis. Results: Most (94%) M. avium intracellulare complex isolates showed in vitro susceptibility to clarithromycin. All M. kansasii isolates were susceptible to rifampicin and ethambutol and 97.1% were susceptible to isoniazid. The majority of rapidly-growing mycobacteria (RGM) demonstrated in vitro susceptibility to amikacin, clarithromycin and cefoxitin. However, in RGM there was a marked increase on the relative risk of having sulfamethoxazole resistance in isolates resistant to ciprofloxacin compared to susceptible isolates. Conclusion: Tested NTM in Portugal revealed in vitro susceptibility to most of the antimicrobials currently recommended for treatment. However, our results also suggest that sulfamethoxazole should be avoided in treatment of RGM resistant to ciprofloxacin (or vice versa). Further trials that correlate the in vitro DST results with the clinical outcome are needed in order to reach conclusions on efficient antimicrobial therapy.Elsevier/ Sociedade Portuguesa de PneumologiaRepositório Científico do Instituto Nacional de SaúdeDurão, VeraSilva, AnabelaMacedo, RitaDurão, PauloSantos-Silva, AndréDuarte, Raquel2022-12-01T01:30:22Z2018-10-082018-10-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6271engPulmonology. 2018 Oct 8. pii: S2531-0437(18)30129-6. doi: 10.1016/j.pulmoe.2018.09.001. [Epub ahead of print]2531-042910.1016/j.pulmoe.2018.09.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:18Zoai:repositorio.insa.pt:10400.18/6271Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:53.432420Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
title Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
spellingShingle Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
Durão, Vera
Antibiotic Resistance
Antimicrobial Treatment
Drug Susceptibility Testing
Nontuberculous mycobacteria
Infecções Gastrointestinais
title_short Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
title_full Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
title_fullStr Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
title_full_unstemmed Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
title_sort Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines
author Durão, Vera
author_facet Durão, Vera
Silva, Anabela
Macedo, Rita
Durão, Paulo
Santos-Silva, André
Duarte, Raquel
author_role author
author2 Silva, Anabela
Macedo, Rita
Durão, Paulo
Santos-Silva, André
Duarte, Raquel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Durão, Vera
Silva, Anabela
Macedo, Rita
Durão, Paulo
Santos-Silva, André
Duarte, Raquel
dc.subject.por.fl_str_mv Antibiotic Resistance
Antimicrobial Treatment
Drug Susceptibility Testing
Nontuberculous mycobacteria
Infecções Gastrointestinais
topic Antibiotic Resistance
Antimicrobial Treatment
Drug Susceptibility Testing
Nontuberculous mycobacteria
Infecções Gastrointestinais
description Supplementary material associated with this article can be found in the online version available at doi:10.1016/j.pulmoe.2018.09.001.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-08
2018-10-08T00:00:00Z
2022-12-01T01:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6271
url http://hdl.handle.net/10400.18/6271
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pulmonology. 2018 Oct 8. pii: S2531-0437(18)30129-6. doi: 10.1016/j.pulmoe.2018.09.001. [Epub ahead of print]
2531-0429
10.1016/j.pulmoe.2018.09.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/ Sociedade Portuguesa de Pneumologia
publisher.none.fl_str_mv Elsevier/ Sociedade Portuguesa de Pneumologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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