Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10216/114829 |
Resumo: | Background: Helicobacter pylori infection is acquired mainly during childhood, but it may occur throughout life. Understanding the determinants of infection at different ages is essential to clarify dynamics of H. pylori related diseases and to design preventive strategies. Aim: To estimate the prevalence of H. pylori infection at the age of 13 and the incidence after a 3-year follow-up and to identify risk factors for infection. Subjects and methods: Adolescents born in 1990 were recruited in schools from Porto. Whole-cell anti-H. pylori IgG antibodies were quantified by ELISA. Prevalence ratios (PR) and incidence rate ratios (RR) adjusted for parental education were computed at baseline (n = 1312) and at follow-up (n = 280). Results: The prevalence was 66.2%, lower in subjects with more educated parents (PR = 0.72, 95%CI: 0.63–0.82), and higher for those having more than one sibling (PR = 1.10, 95%CI: 1.02–1.19) and for smokers (PR = 1.11, 95%CI: 1.02–1.20). The incidence was 4.1/100 person-years. Smoking (RR = 2.35, 95%CI: 1.16–4.75) and type of school (RR = 0.38, 95%CI: 0.16–0.95) were associated with the incidence of infection. Conclusions: Prevalence and incidence of H. pylori infection were high, suggesting that gastric cancer will remain an important public health problem in this generation of Portuguese. We identified smoking as a modifiable risk factor for infection. |
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Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)Helicobacter pylori - Adolescents - PortugalBackground: Helicobacter pylori infection is acquired mainly during childhood, but it may occur throughout life. Understanding the determinants of infection at different ages is essential to clarify dynamics of H. pylori related diseases and to design preventive strategies. Aim: To estimate the prevalence of H. pylori infection at the age of 13 and the incidence after a 3-year follow-up and to identify risk factors for infection. Subjects and methods: Adolescents born in 1990 were recruited in schools from Porto. Whole-cell anti-H. pylori IgG antibodies were quantified by ELISA. Prevalence ratios (PR) and incidence rate ratios (RR) adjusted for parental education were computed at baseline (n = 1312) and at follow-up (n = 280). Results: The prevalence was 66.2%, lower in subjects with more educated parents (PR = 0.72, 95%CI: 0.63–0.82), and higher for those having more than one sibling (PR = 1.10, 95%CI: 1.02–1.19) and for smokers (PR = 1.11, 95%CI: 1.02–1.20). The incidence was 4.1/100 person-years. Smoking (RR = 2.35, 95%CI: 1.16–4.75) and type of school (RR = 0.38, 95%CI: 0.16–0.95) were associated with the incidence of infection. Conclusions: Prevalence and incidence of H. pylori infection were high, suggesting that gastric cancer will remain an important public health problem in this generation of Portuguese. We identified smoking as a modifiable risk factor for infection.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114829eng1590-865810.1016/j.dld.2012.11.009Bastos, JPeleteiro, BPinto, HMarinho, AGuimaraes, JTRamos, Einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:41:07Zoai:repositorio-aberto.up.pt:10216/114829Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:29:39.711710Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
title |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
spellingShingle |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) Bastos, J Helicobacter pylori - Adolescents - Portugal |
title_short |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
title_full |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
title_fullStr |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
title_full_unstemmed |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
title_sort |
Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen) |
author |
Bastos, J |
author_facet |
Bastos, J Peleteiro, B Pinto, H Marinho, A Guimaraes, JT Ramos, E |
author_role |
author |
author2 |
Peleteiro, B Pinto, H Marinho, A Guimaraes, JT Ramos, E |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bastos, J Peleteiro, B Pinto, H Marinho, A Guimaraes, JT Ramos, E |
dc.subject.por.fl_str_mv |
Helicobacter pylori - Adolescents - Portugal |
topic |
Helicobacter pylori - Adolescents - Portugal |
description |
Background: Helicobacter pylori infection is acquired mainly during childhood, but it may occur throughout life. Understanding the determinants of infection at different ages is essential to clarify dynamics of H. pylori related diseases and to design preventive strategies. Aim: To estimate the prevalence of H. pylori infection at the age of 13 and the incidence after a 3-year follow-up and to identify risk factors for infection. Subjects and methods: Adolescents born in 1990 were recruited in schools from Porto. Whole-cell anti-H. pylori IgG antibodies were quantified by ELISA. Prevalence ratios (PR) and incidence rate ratios (RR) adjusted for parental education were computed at baseline (n = 1312) and at follow-up (n = 280). Results: The prevalence was 66.2%, lower in subjects with more educated parents (PR = 0.72, 95%CI: 0.63–0.82), and higher for those having more than one sibling (PR = 1.10, 95%CI: 1.02–1.19) and for smokers (PR = 1.11, 95%CI: 1.02–1.20). The incidence was 4.1/100 person-years. Smoking (RR = 2.35, 95%CI: 1.16–4.75) and type of school (RR = 0.38, 95%CI: 0.16–0.95) were associated with the incidence of infection. Conclusions: Prevalence and incidence of H. pylori infection were high, suggesting that gastric cancer will remain an important public health problem in this generation of Portuguese. We identified smoking as a modifiable risk factor for infection. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10216/114829 |
url |
http://hdl.handle.net/10216/114829 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1590-8658 10.1016/j.dld.2012.11.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136207219720192 |