Mitochondrial agents for bipolar disorder

Detalhes bibliográficos
Autor(a) principal: Pereira, Círia
Data de Publicação: 2018
Outros Autores: Chavarria, Victor, Vian, João, Ashton, Melanie Maree, Berk, Michael, Marx, Wolfgang, Dean, Olivia May
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50449
Resumo: © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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spelling Mitochondrial agents for bipolar disorderAdjunctiveBipolar disorderComplimentary therapiesMitochondria© The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comBackground: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit. Methods: This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder. A Clinicaltrials.gov and ANZCTR search was conducted for complete and ongoing trials on mitochondrial agents used in psychiatric disorders. A PubMed search was also conducted for literature published between January 1981 and July 2017. Systematic reviews, randomized controlled trials, observational studies, case series, and animal studies with an emphasis on agents affecting mitochondrial function and its role in bipolar disorder were included. The search was augmented by manually searching the references of key papers and related literature. The results were presented as a narrative review. Results: Mitochondrial agents offer new horizons in mood disorder treatment. While some negative effects have been reported, most compounds are overall well tolerated and have generally benign side-effect profiles. Conclusions: The study of neuroinflammation, neurodegeneration, and mitochondrial function has contributed the understanding of bipolar disorder's pathophysiology. Agents targeting these pathways could be a potential therapeutic strategy. Future directions include identification of novel candidate mitochondrial modulators as well as rigorous and well-powered clinical trials.M.B. is supported by a NHMRC Senior Principal Research Fellowship (GNT1059660).Oxford University PressRepositório da Universidade de LisboaPereira, CíriaChavarria, VictorVian, JoãoAshton, Melanie MareeBerk, MichaelMarx, WolfgangDean, Olivia May2021-12-17T16:23:08Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50449engInt J Neuropsychopharmacol. 2018 Jun 1;21(6):550-5691461-145710.1093/ijnp/pyy0181469-5111info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:37Zoai:repositorio.ul.pt:10451/50449Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:53.838980Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mitochondrial agents for bipolar disorder
title Mitochondrial agents for bipolar disorder
spellingShingle Mitochondrial agents for bipolar disorder
Pereira, Círia
Adjunctive
Bipolar disorder
Complimentary therapies
Mitochondria
title_short Mitochondrial agents for bipolar disorder
title_full Mitochondrial agents for bipolar disorder
title_fullStr Mitochondrial agents for bipolar disorder
title_full_unstemmed Mitochondrial agents for bipolar disorder
title_sort Mitochondrial agents for bipolar disorder
author Pereira, Círia
author_facet Pereira, Círia
Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
author_role author
author2 Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira, Círia
Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
dc.subject.por.fl_str_mv Adjunctive
Bipolar disorder
Complimentary therapies
Mitochondria
topic Adjunctive
Bipolar disorder
Complimentary therapies
Mitochondria
description © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-12-17T16:23:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50449
url http://hdl.handle.net/10451/50449
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Neuropsychopharmacol. 2018 Jun 1;21(6):550-569
1461-1457
10.1093/ijnp/pyy018
1469-5111
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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