Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients

Detalhes bibliográficos
Autor(a) principal: Torres, T.
Data de Publicação: 2014
Outros Autores: Bettencourt, N., Ferreira, J., Carvalho, C., Mendonca, D., Pinho-Costa, P., Vasconcelos, C., Selores, M., Silva, B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/2871
Resumo: Letter to the Editor
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spelling Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patientsTNF- a gene PolymorphismsCoronary Artery CalcificationPsoriasisDoenças GenéticasLetter to the EditorPsoriasis is a systemic inflammatory disorder associated with numerous medical comorbidities and increased risk of cardiovascular disease (CVD. Psoriasis’ systemic inflammation may play an important role in the accelerated atherosclerosis observed in these patients2 as inflammatory processes play a key role in atherogenesis. Psoriasis and atherosclerosis share some pathological features including endothelial dysfunction, alteration in angiogenesis and some inflammatory pathways. TNF-a is a potent pro-inflammatory cytokine that has been implicated in psoriasis and atherosclerosis pathogenesis and its synthesis is tightly regulated at gene transcription level. TNF-a gene promoter region contains several single-nucleotide polymorphisms (SNP) that influence TNF-a production. Several TNF-a gene polymorphisms have been associated with psoriasis and CVD. A recent meta-analysis suggested that TNF-a rs1800629(308G/A) polymorphism was associated with decreased risk of psoriasis, whereas TNF-a rs361525(238G/A) was associated with increased risk. Regarding TNF-a rs1799964 (1031T/C) polymorphism, existing data are limited and contradictory.8 Since psoriasis morbidity and mortality are strongly linked to accelerated atherosclerosis, determining the genetic contribution for cardiovascular morbidity in psoriasis patients becomes an issue of major importance. The aim of this study was to evaluate the contribution of TNF-a rs361525(238G/A), TNF-a rs1800629(308G/A) and TNFa rs1799964(1031T/C) gene polymorphisms to coronary artery calcification (CAC) in severe psoriasis patients.This study was supported in part by an unrestricted grant from the Portuguese Society of Dermatology and Venereology.Wiley/ European Academy of Dermatology and VenereologyRepositório Científico do Instituto Nacional de SaúdeTorres, T.Bettencourt, N.Ferreira, J.Carvalho, C.Mendonca, D.Pinho-Costa, P.Vasconcelos, C.Selores, M.Silva, B.2015-02-17T13:42:51Z2014-08-292014-08-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/2871engJ Eur Acad Dermatol Venereol. 2016 Jan;30(1):191-3. doi: 10.1111/jdv.12706. Epub 2014 Aug 290926-995910.1111/jdv.12706info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:30Zoai:repositorio.insa.pt:10400.18/2871Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:52.180553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
title Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
spellingShingle Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
Torres, T.
TNF- a gene Polymorphisms
Coronary Artery Calcification
Psoriasis
Doenças Genéticas
title_short Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
title_full Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
title_fullStr Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
title_full_unstemmed Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
title_sort Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients
author Torres, T.
author_facet Torres, T.
Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonca, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
author_role author
author2 Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonca, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Torres, T.
Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonca, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
dc.subject.por.fl_str_mv TNF- a gene Polymorphisms
Coronary Artery Calcification
Psoriasis
Doenças Genéticas
topic TNF- a gene Polymorphisms
Coronary Artery Calcification
Psoriasis
Doenças Genéticas
description Letter to the Editor
publishDate 2014
dc.date.none.fl_str_mv 2014-08-29
2014-08-29T00:00:00Z
2015-02-17T13:42:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/2871
url http://hdl.handle.net/10400.18/2871
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Eur Acad Dermatol Venereol. 2016 Jan;30(1):191-3. doi: 10.1111/jdv.12706. Epub 2014 Aug 29
0926-9959
10.1111/jdv.12706
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley/ European Academy of Dermatology and Venereology
publisher.none.fl_str_mv Wiley/ European Academy of Dermatology and Venereology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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