Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://repositorio-aberto.up.pt/handle/10216/117925 |
Resumo: | Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and post-translationally targeted to the organelle by the soluble factor PEX5. Besides a role as a receptor, and probably as a chaperone, PEX5 also holds the key to the matrix of the organelle. Indeed, the available data suggest that PEX5 itself pushes these proteins across the peroxisomal membrane using as driving force the strong protein-protein interactions that it establishes with components of the peroxisomal membrane docking/translocation module (DTM). In recent years, much has been learned on how this transport system is reset and kept fine-tuned. Notably, this involves covalent modification of PEX5 with ubiquitin. Two types of PEX5 ubiquitination have been characterized: monoubiquitination at a conserved cysteine, a mandatory event for the extraction of PEX5 from the DTM; and polyubiquitination, probably the result of a quality control mechanism aiming at clearing the DTM from entangled PEX5 molecules. Monoubiquitination of PEX5 is transient in nature and the factors that reverse this modification have recently been identified. |
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Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptorDeubiquitinationMonoubiquitinationPEX5PolyubiquitinationProtein traffickingTransient ubiquitinationPeroxisomal matrix proteins are synthesized on cytosolic ribosomes and post-translationally targeted to the organelle by the soluble factor PEX5. Besides a role as a receptor, and probably as a chaperone, PEX5 also holds the key to the matrix of the organelle. Indeed, the available data suggest that PEX5 itself pushes these proteins across the peroxisomal membrane using as driving force the strong protein-protein interactions that it establishes with components of the peroxisomal membrane docking/translocation module (DTM). In recent years, much has been learned on how this transport system is reset and kept fine-tuned. Notably, this involves covalent modification of PEX5 with ubiquitin. Two types of PEX5 ubiquitination have been characterized: monoubiquitination at a conserved cysteine, a mandatory event for the extraction of PEX5 from the DTM; and polyubiquitination, probably the result of a quality control mechanism aiming at clearing the DTM from entangled PEX5 molecules. Monoubiquitination of PEX5 is transient in nature and the factors that reverse this modification have recently been identified.Springer-Verlag Wien20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/117925eng10.1007/978-3-7091-1788-0_16Rodrigues, TAFrancisco, TCarvalho, APinto, MPGrou, CPAzevedo, JEinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:08:02Zoai:repositorio-aberto.up.pt:10216/117925Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:16:23.957299Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
title |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
spellingShingle |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor Rodrigues, TA Deubiquitination Monoubiquitination PEX5 Polyubiquitination Protein trafficking Transient ubiquitination |
title_short |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
title_full |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
title_fullStr |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
title_full_unstemmed |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
title_sort |
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor |
author |
Rodrigues, TA |
author_facet |
Rodrigues, TA Francisco, T Carvalho, A Pinto, MP Grou, CP Azevedo, JE |
author_role |
author |
author2 |
Francisco, T Carvalho, A Pinto, MP Grou, CP Azevedo, JE |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, TA Francisco, T Carvalho, A Pinto, MP Grou, CP Azevedo, JE |
dc.subject.por.fl_str_mv |
Deubiquitination Monoubiquitination PEX5 Polyubiquitination Protein trafficking Transient ubiquitination |
topic |
Deubiquitination Monoubiquitination PEX5 Polyubiquitination Protein trafficking Transient ubiquitination |
description |
Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and post-translationally targeted to the organelle by the soluble factor PEX5. Besides a role as a receptor, and probably as a chaperone, PEX5 also holds the key to the matrix of the organelle. Indeed, the available data suggest that PEX5 itself pushes these proteins across the peroxisomal membrane using as driving force the strong protein-protein interactions that it establishes with components of the peroxisomal membrane docking/translocation module (DTM). In recent years, much has been learned on how this transport system is reset and kept fine-tuned. Notably, this involves covalent modification of PEX5 with ubiquitin. Two types of PEX5 ubiquitination have been characterized: monoubiquitination at a conserved cysteine, a mandatory event for the extraction of PEX5 from the DTM; and polyubiquitination, probably the result of a quality control mechanism aiming at clearing the DTM from entangled PEX5 molecules. Monoubiquitination of PEX5 is transient in nature and the factors that reverse this modification have recently been identified. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio-aberto.up.pt/handle/10216/117925 |
url |
https://repositorio-aberto.up.pt/handle/10216/117925 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1007/978-3-7091-1788-0_16 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer-Verlag Wien |
publisher.none.fl_str_mv |
Springer-Verlag Wien |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799136083768770561 |