A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/137939 |
Resumo: | In contrast to many protein translocases that use ATP or GTP hydrolysis as the driving force to transport proteins across biological membranes, the peroxisomal matrix protein import machinery relies on a regulated self-assembly mechanism for this purpose and uses ATP hydrolysis only to reset its components. The ATP-dependent protein complex in charge of resetting this machinery—the Receptor Export Module (REM)—comprises two members of the “ATPases Associated with diverse cellular Activities” (AAA+) family, PEX1 and PEX6, and a membrane protein that anchors the ATPases to the organelle membrane. In recent years, a large amount of data on the structure/function of the REM complex has become available. Here, we discuss the main findings and their mechanistic implications. |
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A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machineryAAA+ ATPasePeroxisomePEX1PEX5PEX6Protein translocationIn contrast to many protein translocases that use ATP or GTP hydrolysis as the driving force to transport proteins across biological membranes, the peroxisomal matrix protein import machinery relies on a regulated self-assembly mechanism for this purpose and uses ATP hydrolysis only to reset its components. The ATP-dependent protein complex in charge of resetting this machinery—the Receptor Export Module (REM)—comprises two members of the “ATPases Associated with diverse cellular Activities” (AAA+) family, PEX1 and PEX6, and a membrane protein that anchors the ATPases to the organelle membrane. In recent years, a large amount of data on the structure/function of the REM complex has become available. Here, we discuss the main findings and their mechanistic implications.MDPI20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/137939eng1661-659610.3390/ijms20215246Pedrosa, AGFrancisco, TFerreira, MJRodrigues, TABarros-Barbosa, AAzevedo, JEinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:36:44Zoai:repositorio-aberto.up.pt:10216/137939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:23:28.159038Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
title |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
spellingShingle |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery Pedrosa, AG AAA+ ATPase Peroxisome PEX1 PEX5 PEX6 Protein translocation |
title_short |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
title_full |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
title_fullStr |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
title_full_unstemmed |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
title_sort |
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery |
author |
Pedrosa, AG |
author_facet |
Pedrosa, AG Francisco, T Ferreira, MJ Rodrigues, TA Barros-Barbosa, A Azevedo, JE |
author_role |
author |
author2 |
Francisco, T Ferreira, MJ Rodrigues, TA Barros-Barbosa, A Azevedo, JE |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pedrosa, AG Francisco, T Ferreira, MJ Rodrigues, TA Barros-Barbosa, A Azevedo, JE |
dc.subject.por.fl_str_mv |
AAA+ ATPase Peroxisome PEX1 PEX5 PEX6 Protein translocation |
topic |
AAA+ ATPase Peroxisome PEX1 PEX5 PEX6 Protein translocation |
description |
In contrast to many protein translocases that use ATP or GTP hydrolysis as the driving force to transport proteins across biological membranes, the peroxisomal matrix protein import machinery relies on a regulated self-assembly mechanism for this purpose and uses ATP hydrolysis only to reset its components. The ATP-dependent protein complex in charge of resetting this machinery—the Receptor Export Module (REM)—comprises two members of the “ATPases Associated with diverse cellular Activities” (AAA+) family, PEX1 and PEX6, and a membrane protein that anchors the ATPases to the organelle membrane. In recent years, a large amount of data on the structure/function of the REM complex has become available. Here, we discuss the main findings and their mechanistic implications. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/137939 |
url |
https://hdl.handle.net/10216/137939 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 10.3390/ijms20215246 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135536300949504 |