Assessment and topographic characterization of locoregional recurrences in head and neck tumours
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109300 https://doi.org/10.1186/s13014-015-0345-4 |
Resumo: | Purpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: method CTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); method TV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and method COM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses. |
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Assessment and topographic characterization of locoregional recurrences in head and neck tumoursHead and neck tumoursRadiation therapyCharacterization of tumour recurrencesGeometric methodsDosimetric assessmentAdolescentAdultAgedAged, 80 and overCarcinoma, Squamous CellChildFemaleFollow-Up StudiesHead and Neck NeoplasmsHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapyRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedRetrospective StudiesRisk AssessmentSurvival RateTomography, X-Ray ComputedYoung AdultPurpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: method CTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); method TV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and method COM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses.Springer Nature2015-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109300http://hdl.handle.net/10316/109300https://doi.org/10.1186/s13014-015-0345-4eng1748-717XFerreira, Brigida CostaMarques, Rui ValeKhouri, LeilaSantos, TâniaSá-Couto, Pedrodo Carmo Lopes, Mariainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-09T11:05:38Zoai:estudogeral.uc.pt:10316/109300Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:30.483230Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
title |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
spellingShingle |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours Ferreira, Brigida Costa Head and neck tumours Radiation therapy Characterization of tumour recurrences Geometric methods Dosimetric assessment Adolescent Adult Aged Aged, 80 and over Carcinoma, Squamous Cell Child Female Follow-Up Studies Head and Neck Neoplasms Humans Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Prognosis Radiotherapy Radiotherapy Planning, Computer-Assisted Radiotherapy, Intensity-Modulated Retrospective Studies Risk Assessment Survival Rate Tomography, X-Ray Computed Young Adult |
title_short |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
title_full |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
title_fullStr |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
title_full_unstemmed |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
title_sort |
Assessment and topographic characterization of locoregional recurrences in head and neck tumours |
author |
Ferreira, Brigida Costa |
author_facet |
Ferreira, Brigida Costa Marques, Rui Vale Khouri, Leila Santos, Tânia Sá-Couto, Pedro do Carmo Lopes, Maria |
author_role |
author |
author2 |
Marques, Rui Vale Khouri, Leila Santos, Tânia Sá-Couto, Pedro do Carmo Lopes, Maria |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Brigida Costa Marques, Rui Vale Khouri, Leila Santos, Tânia Sá-Couto, Pedro do Carmo Lopes, Maria |
dc.subject.por.fl_str_mv |
Head and neck tumours Radiation therapy Characterization of tumour recurrences Geometric methods Dosimetric assessment Adolescent Adult Aged Aged, 80 and over Carcinoma, Squamous Cell Child Female Follow-Up Studies Head and Neck Neoplasms Humans Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Prognosis Radiotherapy Radiotherapy Planning, Computer-Assisted Radiotherapy, Intensity-Modulated Retrospective Studies Risk Assessment Survival Rate Tomography, X-Ray Computed Young Adult |
topic |
Head and neck tumours Radiation therapy Characterization of tumour recurrences Geometric methods Dosimetric assessment Adolescent Adult Aged Aged, 80 and over Carcinoma, Squamous Cell Child Female Follow-Up Studies Head and Neck Neoplasms Humans Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Prognosis Radiotherapy Radiotherapy Planning, Computer-Assisted Radiotherapy, Intensity-Modulated Retrospective Studies Risk Assessment Survival Rate Tomography, X-Ray Computed Young Adult |
description |
Purpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: method CTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); method TV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and method COM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109300 http://hdl.handle.net/10316/109300 https://doi.org/10.1186/s13014-015-0345-4 |
url |
http://hdl.handle.net/10316/109300 https://doi.org/10.1186/s13014-015-0345-4 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1748-717X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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