A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Detalhes bibliográficos
Autor(a) principal: Duong, T
Data de Publicação: 2021
Outros Autores: López-Iglesias, C, Szewczyk, PK, Stachewicz, U, Barros, JAR, Alvarez-Lorenzo, C, Alnaief, M, García-González, CA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152499
Resumo: Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery.
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spelling A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug AdministrationAerogelsDry powder inhalers (DPIs)Porous particlesPowder technologyPulmonary deliveryPulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152499eng2296-418510.3389/fbioe.2021.671381Duong, TLópez-Iglesias, CSzewczyk, PKStachewicz, UBarros, JARAlvarez-Lorenzo, CAlnaief, MGarcía-González, CAinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:02:23Zoai:repositorio-aberto.up.pt:10216/152499Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:32:20.883354Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
title A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
spellingShingle A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
Duong, T
Aerogels
Dry powder inhalers (DPIs)
Porous particles
Powder technology
Pulmonary delivery
title_short A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
title_full A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
title_fullStr A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
title_full_unstemmed A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
title_sort A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
author Duong, T
author_facet Duong, T
López-Iglesias, C
Szewczyk, PK
Stachewicz, U
Barros, JAR
Alvarez-Lorenzo, C
Alnaief, M
García-González, CA
author_role author
author2 López-Iglesias, C
Szewczyk, PK
Stachewicz, U
Barros, JAR
Alvarez-Lorenzo, C
Alnaief, M
García-González, CA
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Duong, T
López-Iglesias, C
Szewczyk, PK
Stachewicz, U
Barros, JAR
Alvarez-Lorenzo, C
Alnaief, M
García-González, CA
dc.subject.por.fl_str_mv Aerogels
Dry powder inhalers (DPIs)
Porous particles
Powder technology
Pulmonary delivery
topic Aerogels
Dry powder inhalers (DPIs)
Porous particles
Powder technology
Pulmonary delivery
description Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152499
url https://hdl.handle.net/10216/152499
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-4185
10.3389/fbioe.2021.671381
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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