Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery

Detalhes bibliográficos
Autor(a) principal: Singh, Caroline Jeya Sheeba Daniel Sunder
Data de Publicação: 2014
Outros Autores: Marslin, Gregory, Mary, Revina Ann, Gregory, Franklin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/26035
Resumo: In the recent years, the “tumor microenvironment” has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses the receptor tyrosine kinase (RTK)-mediated growth factor signaling, steroid hormone signaling, ancient signaling pathways and other molecules that are involved in tumorigenesis and how they interact with each other to create a complex tumor microenvironment. In the second part, we bring together the recent nanocarriers-mediated drug delivery approaches to target the signaling pathways/molecules present in the tumor microenvironment.
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spelling Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug deliveryTumor microenvironmentFunctionalizationSignalling pathwaysNanoparticle-mediated drug deliveryActive targetingsignaling pathwaysScience & TechnologyIn the recent years, the “tumor microenvironment” has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses the receptor tyrosine kinase (RTK)-mediated growth factor signaling, steroid hormone signaling, ancient signaling pathways and other molecules that are involved in tumorigenesis and how they interact with each other to create a complex tumor microenvironment. In the second part, we bring together the recent nanocarriers-mediated drug delivery approaches to target the signaling pathways/molecules present in the tumor microenvironment.Fundação para a Ciência e a Tecnologia (FCT)Walter de Gruyter GmbHUniversidade do MinhoSingh, Caroline Jeya Sheeba Daniel SunderMarslin, GregoryMary, Revina AnnGregory, Franklin20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/26035eng2191-909710.1515/ntrev-2013-0032http://www.degruyter.com/view/j/ntrev.just-accepted/ntrev-2013-0032/ntrev-2013-0032.xmlinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:08:16Zoai:repositorium.sdum.uminho.pt:1822/26035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:59:29.185811Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
title Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
spellingShingle Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
Singh, Caroline Jeya Sheeba Daniel Sunder
Tumor microenvironment
Functionalization
Signalling pathways
Nanoparticle-mediated drug delivery
Active targeting
signaling pathways
Science & Technology
title_short Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
title_full Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
title_fullStr Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
title_full_unstemmed Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
title_sort Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
author Singh, Caroline Jeya Sheeba Daniel Sunder
author_facet Singh, Caroline Jeya Sheeba Daniel Sunder
Marslin, Gregory
Mary, Revina Ann
Gregory, Franklin
author_role author
author2 Marslin, Gregory
Mary, Revina Ann
Gregory, Franklin
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Singh, Caroline Jeya Sheeba Daniel Sunder
Marslin, Gregory
Mary, Revina Ann
Gregory, Franklin
dc.subject.por.fl_str_mv Tumor microenvironment
Functionalization
Signalling pathways
Nanoparticle-mediated drug delivery
Active targeting
signaling pathways
Science & Technology
topic Tumor microenvironment
Functionalization
Signalling pathways
Nanoparticle-mediated drug delivery
Active targeting
signaling pathways
Science & Technology
description In the recent years, the “tumor microenvironment” has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses the receptor tyrosine kinase (RTK)-mediated growth factor signaling, steroid hormone signaling, ancient signaling pathways and other molecules that are involved in tumorigenesis and how they interact with each other to create a complex tumor microenvironment. In the second part, we bring together the recent nanocarriers-mediated drug delivery approaches to target the signaling pathways/molecules present in the tumor microenvironment.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/26035
url http://hdl.handle.net/1822/26035
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2191-9097
10.1515/ntrev-2013-0032
http://www.degruyter.com/view/j/ntrev.just-accepted/ntrev-2013-0032/ntrev-2013-0032.xml
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Walter de Gruyter GmbH
publisher.none.fl_str_mv Walter de Gruyter GmbH
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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