Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103976 https://doi.org/10.1111/eci.13667 |
Resumo: | Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets. |
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Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable dietsNAFLD treatment; gut-liver axis protection; liver-adipose tissue axis; mushrooms; non-communicable diseases; sustainable healthy dietsHumansNon-alcoholic Fatty Liver DiseaseAgaricalesNon-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets.2022-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103976http://hdl.handle.net/10316/103976https://doi.org/10.1111/eci.13667eng0014-29721365-2362https://onlinelibrary.wiley.com/doi/epdf/10.1111/eci.13667Fontes, AdrianaRamalho-Santos, JoãoZischka, HansAzul, Anabela Marisa de Jesus Rodriguesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-10T11:04:56Zoai:estudogeral.uc.pt:10316/103976Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:43.006706Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
title |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
spellingShingle |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets Fontes, Adriana NAFLD treatment; gut-liver axis protection; liver-adipose tissue axis; mushrooms; non-communicable diseases; sustainable healthy diets Humans Non-alcoholic Fatty Liver Disease Agaricales |
title_short |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
title_full |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
title_fullStr |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
title_full_unstemmed |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
title_sort |
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets |
author |
Fontes, Adriana |
author_facet |
Fontes, Adriana Ramalho-Santos, João Zischka, Hans Azul, Anabela Marisa de Jesus Rodrigues |
author_role |
author |
author2 |
Ramalho-Santos, João Zischka, Hans Azul, Anabela Marisa de Jesus Rodrigues |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Fontes, Adriana Ramalho-Santos, João Zischka, Hans Azul, Anabela Marisa de Jesus Rodrigues |
dc.subject.por.fl_str_mv |
NAFLD treatment; gut-liver axis protection; liver-adipose tissue axis; mushrooms; non-communicable diseases; sustainable healthy diets Humans Non-alcoholic Fatty Liver Disease Agaricales |
topic |
NAFLD treatment; gut-liver axis protection; liver-adipose tissue axis; mushrooms; non-communicable diseases; sustainable healthy diets Humans Non-alcoholic Fatty Liver Disease Agaricales |
description |
Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103976 http://hdl.handle.net/10316/103976 https://doi.org/10.1111/eci.13667 |
url |
http://hdl.handle.net/10316/103976 https://doi.org/10.1111/eci.13667 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0014-2972 1365-2362 https://onlinelibrary.wiley.com/doi/epdf/10.1111/eci.13667 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134099204472832 |