From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8154 |
Resumo: | Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc. |
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From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitutionTemporomandibular discDecellularizationExtracellular matrixCurrent treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc.MDPIIC-OnlineTrindade, DanielaAlves, NunoMoura, Carla2023-02-23T15:17:01Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8154engTrindade, D.; Alves, N.; Moura, C. From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution. J. Funct. Biomater. 2022, 13, 61. https://doi.org/ 10.3390/jfb130200612079-498310.3390/jfb13020061info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:56:38Zoai:iconline.ipleiria.pt:10400.8/8154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:50:55.133254Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
title |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
spellingShingle |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution Trindade, Daniela Temporomandibular disc Decellularization Extracellular matrix |
title_short |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
title_full |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
title_fullStr |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
title_full_unstemmed |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
title_sort |
From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution |
author |
Trindade, Daniela |
author_facet |
Trindade, Daniela Alves, Nuno Moura, Carla |
author_role |
author |
author2 |
Alves, Nuno Moura, Carla |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Trindade, Daniela Alves, Nuno Moura, Carla |
dc.subject.por.fl_str_mv |
Temporomandibular disc Decellularization Extracellular matrix |
topic |
Temporomandibular disc Decellularization Extracellular matrix |
description |
Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-02-23T15:17:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8154 |
url |
http://hdl.handle.net/10400.8/8154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Trindade, D.; Alves, N.; Moura, C. From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution. J. Funct. Biomater. 2022, 13, 61. https://doi.org/ 10.3390/jfb13020061 2079-4983 10.3390/jfb13020061 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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