Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/150578 |
Resumo: | Funding Information: This work is part of the project Centro-01-0145- FEDER-000019—C4—Centro de Competências em Cloud Computing supported by the European Regional Development Fund through the “Programa Operacional Regional do Centro (Centro 2020)—Sistema de Apoio à Investigação Científica e Tecnológica—Programas Integrados de IC&DT (Covilhã)”. The authors acknowledge the Laboratório de Fármaco-Toxicologia for the funding support. This work was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020 and the CEF project UIDB/00239/2020, and financed by national funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES. It was also supported by the Applied Molecular Biosciences Unit UCIBIO (UIDB/04378/2020 and UIDP/04378/2020) and the Associate Laboratory Institute for Health and Bioeconomy—i4HB (project LA/P/0140/2020), which are financed by national funds from FCT/MCTES. Publisher Copyright: © 2022 by the authors. |
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Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female InfertilityA Pilot Studyendometriosisfollicular fluidgas chromatography–mass spectrometryinfertilitypolycystic ovary syndromepremature ovarian failuresolid-phase microextractionvolatile organic compoundsMedicine (miscellaneous)Biochemistry, Genetics and Molecular Biology(all)SDG 3 - Good Health and Well-beingFunding Information: This work is part of the project Centro-01-0145- FEDER-000019—C4—Centro de Competências em Cloud Computing supported by the European Regional Development Fund through the “Programa Operacional Regional do Centro (Centro 2020)—Sistema de Apoio à Investigação Científica e Tecnológica—Programas Integrados de IC&DT (Covilhã)”. The authors acknowledge the Laboratório de Fármaco-Toxicologia for the funding support. This work was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020 and the CEF project UIDB/00239/2020, and financed by national funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES. It was also supported by the Applied Molecular Biosciences Unit UCIBIO (UIDB/04378/2020 and UIDP/04378/2020) and the Associate Laboratory Institute for Health and Bioeconomy—i4HB (project LA/P/0140/2020), which are financed by national funds from FCT/MCTES. Publisher Copyright: © 2022 by the authors.Due to its high prevalence, infertility has become a prominent public health issue, posing a significant challenge to modern reproductive medicine. Some clinical conditions that lead to female infertility include polycystic ovary syndrome (PCOS), endometriosis, and premature ovarian failure (POF). Follicular fluid (FF) is the biological matrix that has the most contact with the oocyte and can, therefore, be used as a predictor of its quality. Volatilomics has emerged as a non-invasive, straightforward, affordable, and simple method for characterizing various diseases and determining the effectiveness of their current therapies. In order to find potential biomarkers of infertility, this study set out to determine the volatomic pattern of the follicular fluid from patients with PCOS, endometriosis, and POF. The chromatographic data integration was performed through solid-phase microextraction (SPME), followed by gas chromatography–mass spectrometry (GC-MS). The findings pointed to specific metabolite patterns as potential biomarkers for the studied diseases. These open the door for further research into the relevant metabolomic pathways to enhance infertility knowledge and diagnostic tools. An extended investigation may, however, produce a new mechanistic understanding of the pathophysiology of the diseases.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNBrinca, Ana TeresaAnjos, OféliaAlves, Maria Manuel CasteleiroSousa, ÂngelaOliani, António HélioBreitenfeld, LuizaPassarinha, Luís A.Ramalhinho, Ana CristinaGallardo, Eugenia2023-03-14T22:45:14Z2022-11-082022-11-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/150578engBrinca, A. T., Anjos, O., Alves, M. M. C., Sousa, Â., Oliani, A. H., Breitenfeld, L., Passarinha, L. A., Ramalhinho, A. C., & Gallardo, E. (2022). Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility: A Pilot Study. Biomedicines, 10(11), [2852]. https://doi.org/10.3390/biomedicines101128522227-9059PURE: 55737799https://doi.org/10.3390/biomedicines10112852info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:37Zoai:run.unl.pt:10362/150578Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:11.947949Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility A Pilot Study |
| title |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| spellingShingle |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility Brinca, Ana Teresa endometriosis follicular fluid gas chromatography–mass spectrometry infertility polycystic ovary syndrome premature ovarian failure solid-phase microextraction volatile organic compounds Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) SDG 3 - Good Health and Well-being |
| title_short |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| title_full |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| title_fullStr |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| title_full_unstemmed |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| title_sort |
Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility |
| author |
Brinca, Ana Teresa |
| author_facet |
Brinca, Ana Teresa Anjos, Ofélia Alves, Maria Manuel Casteleiro Sousa, Ângela Oliani, António Hélio Breitenfeld, Luiza Passarinha, Luís A. Ramalhinho, Ana Cristina Gallardo, Eugenia |
| author_role |
author |
| author2 |
Anjos, Ofélia Alves, Maria Manuel Casteleiro Sousa, Ângela Oliani, António Hélio Breitenfeld, Luiza Passarinha, Luís A. Ramalhinho, Ana Cristina Gallardo, Eugenia |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Brinca, Ana Teresa Anjos, Ofélia Alves, Maria Manuel Casteleiro Sousa, Ângela Oliani, António Hélio Breitenfeld, Luiza Passarinha, Luís A. Ramalhinho, Ana Cristina Gallardo, Eugenia |
| dc.subject.por.fl_str_mv |
endometriosis follicular fluid gas chromatography–mass spectrometry infertility polycystic ovary syndrome premature ovarian failure solid-phase microextraction volatile organic compounds Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) SDG 3 - Good Health and Well-being |
| topic |
endometriosis follicular fluid gas chromatography–mass spectrometry infertility polycystic ovary syndrome premature ovarian failure solid-phase microextraction volatile organic compounds Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) SDG 3 - Good Health and Well-being |
| description |
Funding Information: This work is part of the project Centro-01-0145- FEDER-000019—C4—Centro de Competências em Cloud Computing supported by the European Regional Development Fund through the “Programa Operacional Regional do Centro (Centro 2020)—Sistema de Apoio à Investigação Científica e Tecnológica—Programas Integrados de IC&DT (Covilhã)”. The authors acknowledge the Laboratório de Fármaco-Toxicologia for the funding support. This work was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020 and the CEF project UIDB/00239/2020, and financed by national funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES. It was also supported by the Applied Molecular Biosciences Unit UCIBIO (UIDB/04378/2020 and UIDP/04378/2020) and the Associate Laboratory Institute for Health and Bioeconomy—i4HB (project LA/P/0140/2020), which are financed by national funds from FCT/MCTES. Publisher Copyright: © 2022 by the authors. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-08 2022-11-08T00:00:00Z 2023-03-14T22:45:14Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/150578 |
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http://hdl.handle.net/10362/150578 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Brinca, A. T., Anjos, O., Alves, M. M. C., Sousa, Â., Oliani, A. H., Breitenfeld, L., Passarinha, L. A., Ramalhinho, A. C., & Gallardo, E. (2022). Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility: A Pilot Study. Biomedicines, 10(11), [2852]. https://doi.org/10.3390/biomedicines10112852 2227-9059 PURE: 55737799 https://doi.org/10.3390/biomedicines10112852 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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17 application/pdf |
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