Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18)
| Autor(a) principal: | |
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| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/6489 |
Resumo: | Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807025/pdf/main.pdf |
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Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18)Case-control StudyEuropeInfluenzaInfluenza VaccineMulticentre StudyVaccine EffectivenessDeterminantes da Saúde e da DoençaVacina AntigripalCuidados de SaúdeEfetividadeI-MOVEFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807025/pdf/main.pdfIntroduction: Influenza A(H3N2) viruses predominated in Europe in 2016–17. In 2017–18 A(H3N2) and A(H1N1)pdm09 viruses co-circulated. The A(H3N2) vaccine component was the same in both seasons; while the A(H1N1)pdm09 component changed in 2017–18. In both seasons, vaccine seed A(H3N2) viruses developed adaptations/alterations during propagation in eggs, impacting antigenicity. Methods: We used the test-negative design in a multicentre primary care case-control study in 12 European countries to measure 2016–17 and 2017–18 influenza vaccine effectiveness (VE) against laboratory-confirmed influenza A(H1N1)pdm09 and A(H3N2) overall and by age group. Results: During the 2017–18 season, the overall VE against influenza A(H1N1)pdm09 was 59% (95% CI: 47–69). Among those aged 0–14, 15–64 and ≥65 years, VE against A(H1N1)pdm09 was 64% (95% CI: 37–79), 50% (95% CI: 28–66) and 66% (95% CI: 42–80), respectively. Overall VE against influenza A(H3N2) was 28% (95% CI: 17–38) in 2016–17 and 13% (95% CI: -15 to 34) in 2017–18. Among 0–14-year-olds VE against A(H3N2) was 28% (95%CI: -10 to 53) and 29% (95% CI: -87 to 73), among 15–64-year-olds 34% (95% CI: 18–46) and 33% (95% CI: -3 to 56) and among those aged ≥65 years 15% (95% CI: -10 to 34) and -9% (95% CI: -74 to 32) in 2016–17 and 2017–18, respectively. Conclusions: Our study suggests the new A(H1N1)pdm09 vaccine component conferred good protection against circulating strains, while VE against A(H3N2) was <35% in 2016–17 and 2017–18. The egg propagation derived antigenic mismatch of the vaccine seed virus with circulating strains may have contributed to this low effectiveness. A(H3N2) seed viruses for vaccines in subsequent seasons may be subject to the same adaptations; in years with lower than expected VE, recommendations of preventive measures other than vaccination should be given in a timely manner.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed funds for the coordination and some study sites under the Framework contract no. ECDC/2014/026 for the individuals aged less than 65 years. The WHO Regional office for Europe has contributed funds for the Romanian study siteElsevierRepositório Científico do Instituto Nacional de SaúdeKissling, EstherPozo, FranciscoBuda, SilkeVilcu, Ana-MariaRizzo, CaterinaGherasim, AlinKrisztina Horváth, JuditBrytting, MiaDomegan, LisaMeijer, AdamParadowska-Stankiewicz, IwonaMachado, AusendaVišekruna Vučina, VesnaLazar, MihaelaJohansen, KariDürrwald, Ralfvan der Werf, SylvieBella, AntoninoLarrauri, AmparoFerenczi, AnnamáriaZakikhany, KatherinaO'Donnell, JoanDijkstra, FrederikaBogusz, JoannaGuiomar, RaquelKurečić Filipović, SanjaPitigoi, DanielaPenttinen, PasiValenciano, MartaGomez, VeronicaKislaya, IrinaNunes, BaltazarI-MOVE/I-MOVE+ study team2021-12-01T01:30:13Z2019-09-172019-09-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6489engVaccine X. 2019 Sep 17;3:100042. doi: 10.1016/j.jvacx.2019.100042. eCollection 2019 Dec 102590-136210.1016/j.jvacx.2019.100042info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:28Zoai:repositorio.insa.pt:10400.18/6489Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:11.588085Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| title |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| spellingShingle |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) Kissling, Esther Case-control Study Europe Influenza Influenza Vaccine Multicentre Study Vaccine Effectiveness Determinantes da Saúde e da Doença Vacina Antigripal Cuidados de Saúde Efetividade I-MOVE |
| title_short |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| title_full |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| title_fullStr |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| title_full_unstemmed |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| title_sort |
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18) |
| author |
Kissling, Esther |
| author_facet |
Kissling, Esther Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Rizzo, Caterina Gherasim, Alin Krisztina Horváth, Judit Brytting, Mia Domegan, Lisa Meijer, Adam Paradowska-Stankiewicz, Iwona Machado, Ausenda Višekruna Vučina, Vesna Lazar, Mihaela Johansen, Kari Dürrwald, Ralf van der Werf, Sylvie Bella, Antonino Larrauri, Amparo Ferenczi, Annamária Zakikhany, Katherina O'Donnell, Joan Dijkstra, Frederika Bogusz, Joanna Guiomar, Raquel Kurečić Filipović, Sanja Pitigoi, Daniela Penttinen, Pasi Valenciano, Marta Gomez, Veronica Kislaya, Irina Nunes, Baltazar I-MOVE/I-MOVE+ study team |
| author_role |
author |
| author2 |
Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Rizzo, Caterina Gherasim, Alin Krisztina Horváth, Judit Brytting, Mia Domegan, Lisa Meijer, Adam Paradowska-Stankiewicz, Iwona Machado, Ausenda Višekruna Vučina, Vesna Lazar, Mihaela Johansen, Kari Dürrwald, Ralf van der Werf, Sylvie Bella, Antonino Larrauri, Amparo Ferenczi, Annamária Zakikhany, Katherina O'Donnell, Joan Dijkstra, Frederika Bogusz, Joanna Guiomar, Raquel Kurečić Filipović, Sanja Pitigoi, Daniela Penttinen, Pasi Valenciano, Marta Gomez, Veronica Kislaya, Irina Nunes, Baltazar I-MOVE/I-MOVE+ study team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Kissling, Esther Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Rizzo, Caterina Gherasim, Alin Krisztina Horváth, Judit Brytting, Mia Domegan, Lisa Meijer, Adam Paradowska-Stankiewicz, Iwona Machado, Ausenda Višekruna Vučina, Vesna Lazar, Mihaela Johansen, Kari Dürrwald, Ralf van der Werf, Sylvie Bella, Antonino Larrauri, Amparo Ferenczi, Annamária Zakikhany, Katherina O'Donnell, Joan Dijkstra, Frederika Bogusz, Joanna Guiomar, Raquel Kurečić Filipović, Sanja Pitigoi, Daniela Penttinen, Pasi Valenciano, Marta Gomez, Veronica Kislaya, Irina Nunes, Baltazar I-MOVE/I-MOVE+ study team |
| dc.subject.por.fl_str_mv |
Case-control Study Europe Influenza Influenza Vaccine Multicentre Study Vaccine Effectiveness Determinantes da Saúde e da Doença Vacina Antigripal Cuidados de Saúde Efetividade I-MOVE |
| topic |
Case-control Study Europe Influenza Influenza Vaccine Multicentre Study Vaccine Effectiveness Determinantes da Saúde e da Doença Vacina Antigripal Cuidados de Saúde Efetividade I-MOVE |
| description |
Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807025/pdf/main.pdf |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-09-17 2019-09-17T00:00:00Z 2021-12-01T01:30:13Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6489 |
| url |
http://hdl.handle.net/10400.18/6489 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Vaccine X. 2019 Sep 17;3:100042. doi: 10.1016/j.jvacx.2019.100042. eCollection 2019 Dec 10 2590-1362 10.1016/j.jvacx.2019.100042 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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