State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73907 |
Resumo: | Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained. |
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State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risksMetal nanoparticlesNanoparticles toxicityReactive oxygen speciesNanoparticles functionalizationCiências Naturais::Ciências BiológicasScience & TechnologyMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained.This work was funded by the Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE) of EU, through the project UIDB/04469/2020 (CEB strategic fund), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoGarcía-Torra, VictorCano, AmandaEspina, MartaEttcheto, MirenCamins, AntoniBarroso, EmmaVazquez-Carrera, ManelGarcía, Maria LuisaSánchez-López, ElenaSouto, Eliana B.2021-08-232021-08-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73907engGarcía-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria Luisa; Sánchez-López, Elena; Souto, Eliana, State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks. Toxics, 9(8), 195, 20212305-630410.3390/toxics9080195https://www.mdpi.com/2305-6304/9/8/195info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:17Zoai:repositorium.sdum.uminho.pt:1822/73907Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:23.543014Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
title |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
spellingShingle |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks García-Torra, Victor Metal nanoparticles Nanoparticles toxicity Reactive oxygen species Nanoparticles functionalization Ciências Naturais::Ciências Biológicas Science & Technology |
title_short |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
title_full |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
title_fullStr |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
title_full_unstemmed |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
title_sort |
State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks |
author |
García-Torra, Victor |
author_facet |
García-Torra, Victor Cano, Amanda Espina, Marta Ettcheto, Miren Camins, Antoni Barroso, Emma Vazquez-Carrera, Manel García, Maria Luisa Sánchez-López, Elena Souto, Eliana B. |
author_role |
author |
author2 |
Cano, Amanda Espina, Marta Ettcheto, Miren Camins, Antoni Barroso, Emma Vazquez-Carrera, Manel García, Maria Luisa Sánchez-López, Elena Souto, Eliana B. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
García-Torra, Victor Cano, Amanda Espina, Marta Ettcheto, Miren Camins, Antoni Barroso, Emma Vazquez-Carrera, Manel García, Maria Luisa Sánchez-López, Elena Souto, Eliana B. |
dc.subject.por.fl_str_mv |
Metal nanoparticles Nanoparticles toxicity Reactive oxygen species Nanoparticles functionalization Ciências Naturais::Ciências Biológicas Science & Technology |
topic |
Metal nanoparticles Nanoparticles toxicity Reactive oxygen species Nanoparticles functionalization Ciências Naturais::Ciências Biológicas Science & Technology |
description |
Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-23 2021-08-23T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73907 |
url |
http://hdl.handle.net/1822/73907 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
García-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria Luisa; Sánchez-López, Elena; Souto, Eliana, State of the art on toxicological mechanisms of metal and metal oxide nanoparticles and strategies to reduce toxicological risks. Toxics, 9(8), 195, 2021 2305-6304 10.3390/toxics9080195 https://www.mdpi.com/2305-6304/9/8/195 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133018635370496 |