Aggressive NK/T cell leukemia/lymphoma associated with EBV.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547 |
Resumo: | The authors describe an unusual case of a young man presenting with fever, asthenia, anorexia and jaundice, associated to hepatosplenomegaly, evolving rapidly to multiorganic failure. Final diagnosis revealed an aggressive NK cell leukemia/lymphoma associated to the Epstein-Barr virus (EBV). The diagnosis, suggested clinically and after bone marrow immunophenotyping, was confirmed by morphologic and immunohistochemical findings on the post-mortem hepatic and splenic biopsy .The tumor cells were positive for CD3 and cytotoxic molecules, TIA, granzyme B and perforin. The herein reported case is a rare clinical entity, only recently recognized and with a difficult early diagnosis. We emphasize the necessity to exclude a Natural Killer cell malignancy in cases with identical characteristics. |
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Aggressive NK/T cell leukemia/lymphoma associated with EBV.Leucemia/linfoma agressivo de células NK/T.The authors describe an unusual case of a young man presenting with fever, asthenia, anorexia and jaundice, associated to hepatosplenomegaly, evolving rapidly to multiorganic failure. Final diagnosis revealed an aggressive NK cell leukemia/lymphoma associated to the Epstein-Barr virus (EBV). The diagnosis, suggested clinically and after bone marrow immunophenotyping, was confirmed by morphologic and immunohistochemical findings on the post-mortem hepatic and splenic biopsy .The tumor cells were positive for CD3 and cytotoxic molecules, TIA, granzyme B and perforin. The herein reported case is a rare clinical entity, only recently recognized and with a difficult early diagnosis. We emphasize the necessity to exclude a Natural Killer cell malignancy in cases with identical characteristics.The authors describe an unusual case of a young man presenting with fever, asthenia, anorexia and jaundice, associated to hepatosplenomegaly, evolving rapidly to multiorganic failure. Final diagnosis revealed an aggressive NK cell leukemia/lymphoma associated to the Epstein-Barr virus (EBV). The diagnosis, suggested clinically and after bone marrow immunophenotyping, was confirmed by morphologic and immunohistochemical findings on the post-mortem hepatic and splenic biopsy .The tumor cells were positive for CD3 and cytotoxic molecules, TIA, granzyme B and perforin. The herein reported case is a rare clinical entity, only recently recognized and with a difficult early diagnosis. We emphasize the necessity to exclude a Natural Killer cell malignancy in cases with identical characteristics.Ordem dos Médicos2011-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547oai:ojs.www.actamedicaportuguesa.com:article/1547Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 649-52Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 649-521646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547/1132Sousa, JamiraCabezuelo, LourdesAlmeida, SérgioFilipe, CarlosSimão, AdéliaCarvalho, ArmandoNascimento Costa, Jinfo:eu-repo/semantics/openAccess2022-12-20T10:58:06Zoai:ojs.www.actamedicaportuguesa.com:article/1547Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:13.528923Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. Leucemia/linfoma agressivo de células NK/T. |
title |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
spellingShingle |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. Sousa, Jamira |
title_short |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
title_full |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
title_fullStr |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
title_full_unstemmed |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
title_sort |
Aggressive NK/T cell leukemia/lymphoma associated with EBV. |
author |
Sousa, Jamira |
author_facet |
Sousa, Jamira Cabezuelo, Lourdes Almeida, Sérgio Filipe, Carlos Simão, Adélia Carvalho, Armando Nascimento Costa, J |
author_role |
author |
author2 |
Cabezuelo, Lourdes Almeida, Sérgio Filipe, Carlos Simão, Adélia Carvalho, Armando Nascimento Costa, J |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Jamira Cabezuelo, Lourdes Almeida, Sérgio Filipe, Carlos Simão, Adélia Carvalho, Armando Nascimento Costa, J |
description |
The authors describe an unusual case of a young man presenting with fever, asthenia, anorexia and jaundice, associated to hepatosplenomegaly, evolving rapidly to multiorganic failure. Final diagnosis revealed an aggressive NK cell leukemia/lymphoma associated to the Epstein-Barr virus (EBV). The diagnosis, suggested clinically and after bone marrow immunophenotyping, was confirmed by morphologic and immunohistochemical findings on the post-mortem hepatic and splenic biopsy .The tumor cells were positive for CD3 and cytotoxic molecules, TIA, granzyme B and perforin. The herein reported case is a rare clinical entity, only recently recognized and with a difficult early diagnosis. We emphasize the necessity to exclude a Natural Killer cell malignancy in cases with identical characteristics. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547 oai:ojs.www.actamedicaportuguesa.com:article/1547 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/1547 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1547/1132 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 649-52 Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 649-52 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130625420034048 |