Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria

Detalhes bibliográficos
Autor(a) principal: Herbert, Fabien
Data de Publicação: 2015
Outros Autores: Tchitchek, Nicolas, Bansal, Devendra, Jacques, Julien, Pathak, Sulabha, Bécavin, Christophe, Fesel, Constantin, Dalko, Esther, Cazenave, Pierre-André, Preda, Cristian, Ravindran, Balachandran, Sharma, Shobhona, Das, Bidyut, Pied, Sylviane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/528
Resumo: Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.
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spelling Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malariaPlasmodium falciparumSevere malariaCerebral malariaAcute-renal failureMalaria associated organ failureIL-17CytokinesBiomarkersPlasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.Indo-French Centre for the Promotion of Advanced Research (IFCPAR project No 3703), International Associated Laboratory Systems Immunology and Genetics of Infectious Diseases (LIA SIGID, CNRS, Lille University and the Department of Biotechnology (DBT), Ministry of Science and Technology of India and the ANR LAbEx Parafrap).BioMed CentralARCAHerbert, FabienTchitchek, NicolasBansal, DevendraJacques, JulienPathak, SulabhaBécavin, ChristopheFesel, ConstantinDalko, EstherCazenave, Pierre-AndréPreda, CristianRavindran, BalachandranSharma, ShobhonaDas, BidyutPied, Sylviane2015-11-30T11:55:25Z2015-11-242015-11-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/528eng10.1186/s12967-015-0731-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:53Zoai:arca.igc.gulbenkian.pt:10400.7/528Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:47.047178Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
title Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
spellingShingle Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
Herbert, Fabien
Plasmodium falciparum
Severe malaria
Cerebral malaria
Acute-renal failure
Malaria associated organ failure
IL-17
Cytokines
Biomarkers
title_short Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
title_full Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
title_fullStr Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
title_full_unstemmed Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
title_sort Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
author Herbert, Fabien
author_facet Herbert, Fabien
Tchitchek, Nicolas
Bansal, Devendra
Jacques, Julien
Pathak, Sulabha
Bécavin, Christophe
Fesel, Constantin
Dalko, Esther
Cazenave, Pierre-André
Preda, Cristian
Ravindran, Balachandran
Sharma, Shobhona
Das, Bidyut
Pied, Sylviane
author_role author
author2 Tchitchek, Nicolas
Bansal, Devendra
Jacques, Julien
Pathak, Sulabha
Bécavin, Christophe
Fesel, Constantin
Dalko, Esther
Cazenave, Pierre-André
Preda, Cristian
Ravindran, Balachandran
Sharma, Shobhona
Das, Bidyut
Pied, Sylviane
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Herbert, Fabien
Tchitchek, Nicolas
Bansal, Devendra
Jacques, Julien
Pathak, Sulabha
Bécavin, Christophe
Fesel, Constantin
Dalko, Esther
Cazenave, Pierre-André
Preda, Cristian
Ravindran, Balachandran
Sharma, Shobhona
Das, Bidyut
Pied, Sylviane
dc.subject.por.fl_str_mv Plasmodium falciparum
Severe malaria
Cerebral malaria
Acute-renal failure
Malaria associated organ failure
IL-17
Cytokines
Biomarkers
topic Plasmodium falciparum
Severe malaria
Cerebral malaria
Acute-renal failure
Malaria associated organ failure
IL-17
Cytokines
Biomarkers
description Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-30T11:55:25Z
2015-11-24
2015-11-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/528
url http://hdl.handle.net/10400.7/528
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/s12967-015-0731-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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