Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries

Detalhes bibliográficos
Autor(a) principal: Magalhães, Vanessa
Data de Publicação: 2022
Outros Autores: Silva, Ana Rita, Silva, Bruna, Zhang, Xiaoying, Dias, Alberto Carlos Pires
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/76779
Resumo: Goji berries have several bioactivities and are consumed as food or used in folk medicine. In this study, the methanolic extracts from red and black goji berries were compared regarding their anti-inflammatory and antioxidant activities. Black goji berries extract has revealed significantly higher anti-inflammatory activity, in either biochemical assays or via decreasing the release of nitric oxide and inhibiting the gene expression of pro-inflammatory cytokines in LPS-stimulated BV2 microglial cells, in comparison with the red goji berries extract. Black goji berries extract has also revealed a significantly higher antioxidant activity, in comparison with the red goji one. Inflammation and related oxidative stress have been brought to light as underlying mechanisms in several chronic diseases, e.g. neurodegenerative diseases. Our results show that these goji berries, particularly the black ones, can have the potential to be a source of pharmacologically active compounds in diseases with an inflammatory and oxidative background.
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spelling Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berriesLycium ruthenicum and Lycium barbarum goji berriesAnti-neuroinflammatory activityAntioxidant activityDigestionIn vitro digestionLycium ruthenicum and Lycium barbarum goji&nbspberriesScience & TechnologyGoji berries have several bioactivities and are consumed as food or used in folk medicine. In this study, the methanolic extracts from red and black goji berries were compared regarding their anti-inflammatory and antioxidant activities. Black goji berries extract has revealed significantly higher anti-inflammatory activity, in either biochemical assays or via decreasing the release of nitric oxide and inhibiting the gene expression of pro-inflammatory cytokines in LPS-stimulated BV2 microglial cells, in comparison with the red goji berries extract. Black goji berries extract has also revealed a significantly higher antioxidant activity, in comparison with the red goji one. Inflammation and related oxidative stress have been brought to light as underlying mechanisms in several chronic diseases, e.g. neurodegenerative diseases. Our results show that these goji berries, particularly the black ones, can have the potential to be a source of pharmacologically active compounds in diseases with an inflammatory and oxidative background.This work was financed by INTERACT - ISAC project, no. NORTE-01- 0145-FEDER-000017, co-financed by the European Regional Develop ment Fund (ERDF) through NORTE 2020 (North Regional Operational Program 2014/2020), by “Contrato Programa” UIDB/04050/2020 (FCT I.P., Portugal), and by the Incubation Project On State Key Laboratory of Biological Resources and Ecological Environment of Qinba Areas [SLGPT2019KF04-04] (China).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMagalhães, VanessaSilva, Ana RitaSilva, BrunaZhang, XiaoyingDias, Alberto Carlos Pires2022-04-022022-04-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/76779engMagalhães, Vanessa; Silva, Ana Rita; Silva, Bruna; Zhang, Xiaoying; Dias, Alberto, Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries. Journal of Functional Foods, 92(105038), 20221756-464610.1016/j.jff.2022.105038https://www.sciencedirect.com/science/article/pii/S1756464622001086info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:05:01Zoai:repositorium.sdum.uminho.pt:1822/76779Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:55:23.612142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
title Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
spellingShingle Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
Magalhães, Vanessa
Lycium ruthenicum and Lycium barbarum goji berries
Anti-neuroinflammatory activity
Antioxidant activity
Digestion
In vitro digestion
Lycium ruthenicum and Lycium barbarum goji&nbsp
berries
Science & Technology
title_short Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
title_full Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
title_fullStr Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
title_full_unstemmed Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
title_sort Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries
author Magalhães, Vanessa
author_facet Magalhães, Vanessa
Silva, Ana Rita
Silva, Bruna
Zhang, Xiaoying
Dias, Alberto Carlos Pires
author_role author
author2 Silva, Ana Rita
Silva, Bruna
Zhang, Xiaoying
Dias, Alberto Carlos Pires
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Magalhães, Vanessa
Silva, Ana Rita
Silva, Bruna
Zhang, Xiaoying
Dias, Alberto Carlos Pires
dc.subject.por.fl_str_mv Lycium ruthenicum and Lycium barbarum goji berries
Anti-neuroinflammatory activity
Antioxidant activity
Digestion
In vitro digestion
Lycium ruthenicum and Lycium barbarum goji&nbsp
berries
Science & Technology
topic Lycium ruthenicum and Lycium barbarum goji berries
Anti-neuroinflammatory activity
Antioxidant activity
Digestion
In vitro digestion
Lycium ruthenicum and Lycium barbarum goji&nbsp
berries
Science & Technology
description Goji berries have several bioactivities and are consumed as food or used in folk medicine. In this study, the methanolic extracts from red and black goji berries were compared regarding their anti-inflammatory and antioxidant activities. Black goji berries extract has revealed significantly higher anti-inflammatory activity, in either biochemical assays or via decreasing the release of nitric oxide and inhibiting the gene expression of pro-inflammatory cytokines in LPS-stimulated BV2 microglial cells, in comparison with the red goji berries extract. Black goji berries extract has also revealed a significantly higher antioxidant activity, in comparison with the red goji one. Inflammation and related oxidative stress have been brought to light as underlying mechanisms in several chronic diseases, e.g. neurodegenerative diseases. Our results show that these goji berries, particularly the black ones, can have the potential to be a source of pharmacologically active compounds in diseases with an inflammatory and oxidative background.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-02
2022-04-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/76779
url https://hdl.handle.net/1822/76779
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Magalhães, Vanessa; Silva, Ana Rita; Silva, Bruna; Zhang, Xiaoying; Dias, Alberto, Comparative studies on the anti-neuroinflammatory and antioxidant activities of black and red goji berries. Journal of Functional Foods, 92(105038), 2022
1756-4646
10.1016/j.jff.2022.105038
https://www.sciencedirect.com/science/article/pii/S1756464622001086
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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