Lung cancer survival and sex-specific patterns in Portugal

Detalhes bibliográficos
Autor(a) principal: Guerreiro, T
Data de Publicação: 2021
Outros Autores: Forjaz, G, Antunes, L, Bastos, J, Mayer, A, Aguiar, P, Araújo, A, Nunes, C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/138323
Resumo: Copyright © 2021 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.
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spelling Lung cancer survival and sex-specific patterns in PortugalA population-based analysisSDG 3 - Good Health and Well-beingCopyright © 2021 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.INTRODUCTION: In Portugal, lung cancer (LC) is the first cause of cancer-related death and of death and disability combined. This study aims to analyze the overall survival (OS) and relative survival (RS) of patients diagnosed with LC in 2009-2011 by socio-demographic and tumor characteristics, and analyze sex-specific patterns. METHODS: We estimated 5-year OS using the Kaplan-Meier method and 5-year net survival through the RS framework. Cox regression modeling was used to determine the hazard ratio (HR) of death associated with each independent variable. FINDINGS: For the 11,523 cases analyzed, median 5-year OS was 264 days (95% confidence interval [CI]: 254.8-273.2), the cumulative OS was 13.6% and RS was 15.1%. Males had a lower median survival (237 days; 95% CI: 228.2-245.7) compared to females (416 days; 95% CI: 384.4-447.6) (p < 0.0001) and lower 5-year RS proportions (12.1% vs. 24.9%). RS progressively decreased with age (41.7% for age-group <40 to 7.2% for ≥80) and stage (66.6% for stage I to 2.4% for stage IV). As predictors of decreased survival, we identified male gender, increasing age >50, histologic types (squamous cell carcinoma, non-small cell lung cancer not otherwise specified, other unspecified and small cell lung cancer), and increasing stage. Compared to women, the risk of death in men was 37.7% higher (HR = 1.386; 95% CI: 1.295-1.484). CONCLUSIONS: The differences between OS and RS were small, reflecting the high lethality of LC. Male gender and older age are factors related to poor prognosis. Histology also plays a role in survival prognosis and varies with gender, but the factor related to the worst survival is stage. Although the study reflects data from a decade ago, and major changes occurred in diagnosis, staging and treatment, particularly for advanced disease, as LC mortality is strongly correlated with late stage diagnosis, all efforts should be made to secure early diagnosis and improve survival prospects.Escola Nacional de Saúde Pública (ENSP)Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)RUNGuerreiro, TForjaz, GAntunes, LBastos, JMayer, AAguiar, PAraújo, ANunes, C2022-05-20T22:13:04Z2021-10-092021-10-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/138323eng2531-0437PURE: 44172828https://doi.org/10.1016/j.pulmoe.2021.09.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:15:37Zoai:run.unl.pt:10362/138323Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:03.725543Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lung cancer survival and sex-specific patterns in Portugal
A population-based analysis
title Lung cancer survival and sex-specific patterns in Portugal
spellingShingle Lung cancer survival and sex-specific patterns in Portugal
Guerreiro, T
SDG 3 - Good Health and Well-being
title_short Lung cancer survival and sex-specific patterns in Portugal
title_full Lung cancer survival and sex-specific patterns in Portugal
title_fullStr Lung cancer survival and sex-specific patterns in Portugal
title_full_unstemmed Lung cancer survival and sex-specific patterns in Portugal
title_sort Lung cancer survival and sex-specific patterns in Portugal
author Guerreiro, T
author_facet Guerreiro, T
Forjaz, G
Antunes, L
Bastos, J
Mayer, A
Aguiar, P
Araújo, A
Nunes, C
author_role author
author2 Forjaz, G
Antunes, L
Bastos, J
Mayer, A
Aguiar, P
Araújo, A
Nunes, C
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
RUN
dc.contributor.author.fl_str_mv Guerreiro, T
Forjaz, G
Antunes, L
Bastos, J
Mayer, A
Aguiar, P
Araújo, A
Nunes, C
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description Copyright © 2021 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-09
2021-10-09T00:00:00Z
2022-05-20T22:13:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/138323
url http://hdl.handle.net/10362/138323
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2531-0437
PURE: 44172828
https://doi.org/10.1016/j.pulmoe.2021.09.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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