Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana Sofia
Data de Publicação: 2017
Outros Autores: Cuco, Célia Marina, Lavareda, Carla, Miguel, Francisco, Ventura, Mafalda, Almeida, Sónia, Pinto, Paula, de Abreu, Tiago Tavares, Rodrigues, Luís Vaz, Seixas, Susana, Bárbara, Cristina, Azkargorta, Mikel, Elortza, Felix, Semedo, Júlio, Field, John K, Mota, Leonor, Matthiesen, Rune
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/32589
Resumo: All experiments including MS analysis were supported by Fundacao para a Ciencia e Tecnologia project EXPL/DTP-PIC/0616/2013. RM is supported by FCT investigator program 2012 (IF/01002/2012). ASC is supported by grant SFRH/BPD/85569/2012 funded by Fundacao para a Ciencia e Tecnologia.
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spelling Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung CancerSDG 3 - Good Health and Well-beingAll experiments including MS analysis were supported by Fundacao para a Ciencia e Tecnologia project EXPL/DTP-PIC/0616/2013. RM is supported by FCT investigator program 2012 (IF/01002/2012). ASC is supported by grant SFRH/BPD/85569/2012 funded by Fundacao para a Ciencia e Tecnologia.Lung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality of lung cancer include improved early detection and stratification of the cancers according to its prognosis and further response to drug treatment. In this study, we performed a detailed mass spectrometry based proteome analysis of acellular bronchoalveolar lavage (BAL) fluid samples on an observational prospective cohort consisting of 90 suspected lung cancer cases which were followed during two years. The thirteen new lung cancer cases diagnosed during the follow up time period clustered, based on liquid chromatography-mass spectrometry (LC-MS) data, with lung cancer cases at the time of BAL collection. Hundred and thirty-tree potential biomarkers were identified showing significantly differential expression when comparing lung cancer versus non-lung cancer. The regulated biomarkers showed a large overlap with biomarkers detected in tissue samples.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNCarvalho, Ana SofiaCuco, Célia MarinaLavareda, CarlaMiguel, FranciscoVentura, MafaldaAlmeida, SóniaPinto, Paulade Abreu, Tiago TavaresRodrigues, Luís VazSeixas, SusanaBárbara, CristinaAzkargorta, MikelElortza, FelixSemedo, JúlioField, John KMota, LeonorMatthiesen, Rune2018-03-15T23:09:20Z2017-02-072017-02-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/32589eng2045-2322PURE: 2259543https://doi.org/10.1038/srep42190info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:18:08Zoai:run.unl.pt:10362/32589Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:29:54.447528Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
title Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
spellingShingle Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
Carvalho, Ana Sofia
SDG 3 - Good Health and Well-being
title_short Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
title_full Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
title_fullStr Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
title_full_unstemmed Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
title_sort Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer
author Carvalho, Ana Sofia
author_facet Carvalho, Ana Sofia
Cuco, Célia Marina
Lavareda, Carla
Miguel, Francisco
Ventura, Mafalda
Almeida, Sónia
Pinto, Paula
de Abreu, Tiago Tavares
Rodrigues, Luís Vaz
Seixas, Susana
Bárbara, Cristina
Azkargorta, Mikel
Elortza, Felix
Semedo, Júlio
Field, John K
Mota, Leonor
Matthiesen, Rune
author_role author
author2 Cuco, Célia Marina
Lavareda, Carla
Miguel, Francisco
Ventura, Mafalda
Almeida, Sónia
Pinto, Paula
de Abreu, Tiago Tavares
Rodrigues, Luís Vaz
Seixas, Susana
Bárbara, Cristina
Azkargorta, Mikel
Elortza, Felix
Semedo, Júlio
Field, John K
Mota, Leonor
Matthiesen, Rune
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Carvalho, Ana Sofia
Cuco, Célia Marina
Lavareda, Carla
Miguel, Francisco
Ventura, Mafalda
Almeida, Sónia
Pinto, Paula
de Abreu, Tiago Tavares
Rodrigues, Luís Vaz
Seixas, Susana
Bárbara, Cristina
Azkargorta, Mikel
Elortza, Felix
Semedo, Júlio
Field, John K
Mota, Leonor
Matthiesen, Rune
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description All experiments including MS analysis were supported by Fundacao para a Ciencia e Tecnologia project EXPL/DTP-PIC/0616/2013. RM is supported by FCT investigator program 2012 (IF/01002/2012). ASC is supported by grant SFRH/BPD/85569/2012 funded by Fundacao para a Ciencia e Tecnologia.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-07
2017-02-07T00:00:00Z
2018-03-15T23:09:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/32589
url http://hdl.handle.net/10362/32589
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 2259543
https://doi.org/10.1038/srep42190
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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