COVID-19 mRNA vaccine and antibody response in lactating women

Detalhes bibliográficos
Autor(a) principal: Charepe, Nadia
Data de Publicação: 2021
Outros Autores: Gonçalves, Juliana, Juliano, A. Margarida, Lopes, David G., Canhão, Helena, Soares, Helena, Serrano, e. Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/126480
Resumo: Funding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s).
id RCAP_cca66c7f02f09985b76d9ce2c04300e5
oai_identifier_str oai:run.unl.pt:10362/126480
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling COVID-19 mRNA vaccine and antibody response in lactating womena prospective cohort studyAntibodiesBreastfeedingCovid-19mRNA vaccinationObstetrics and GynaecologySDG 3 - Good Health and Well-beingFunding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s).Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. A Few studies have shown the presence of antibodies in breastmilk after vaccination. The aim of this work is to study possible antibodies transfer via breastmilk and also the immunological characteristics of lactating women compared to non-lactating women, after using the BNT162b2 Pfizer vaccine. Methods: This is a prospective cohort study with a convenience homogenous sample of 24 healthcare workers (14 lactating and 10 non-lactating women) enrolled at the time of COVID-19 vaccination. Clinical data was registered in a questionnaire. Titers of SARS-CoV-2 spike IgG, IgA and IgM were quantified in post vaccination blood and human milk. Antibody quantification was performed by an in-house ELISA to SARS-CoV-2 trimeric spike protein. Results: All women showed immunity after vaccination with positive antibodies for IgM, IgA and IgG antibodies. The dominant serum antibody response was IgG. Modest levels of antibodies in breastmilk of lactating mothers were observed in this study, especially IgG in 42.9%. There was a moderate association between higher titers of IgG and a longer duration of breastfeeding (R= 0.55, p=0.041). Conclusions: Evidence of antibody transfer in human milk after COVID-19 vaccination is scarce. The presence of antibodies in human milk is reported, but immunization through breastfeeding is still to be established.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNCharepe, NadiaGonçalves, JulianaJuliano, A. MargaridaLopes, David G.Canhão, HelenaSoares, HelenaSerrano, e. Fátima2021-10-22T03:43:03Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/126480eng1471-2393PURE: 33996755https://doi.org/10.1186/s12884-021-04051-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:54Zoai:run.unl.pt:10362/126480Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:53.716872Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv COVID-19 mRNA vaccine and antibody response in lactating women
a prospective cohort study
title COVID-19 mRNA vaccine and antibody response in lactating women
spellingShingle COVID-19 mRNA vaccine and antibody response in lactating women
Charepe, Nadia
Antibodies
Breastfeeding
Covid-19
mRNA vaccination
Obstetrics and Gynaecology
SDG 3 - Good Health and Well-being
title_short COVID-19 mRNA vaccine and antibody response in lactating women
title_full COVID-19 mRNA vaccine and antibody response in lactating women
title_fullStr COVID-19 mRNA vaccine and antibody response in lactating women
title_full_unstemmed COVID-19 mRNA vaccine and antibody response in lactating women
title_sort COVID-19 mRNA vaccine and antibody response in lactating women
author Charepe, Nadia
author_facet Charepe, Nadia
Gonçalves, Juliana
Juliano, A. Margarida
Lopes, David G.
Canhão, Helena
Soares, Helena
Serrano, e. Fátima
author_role author
author2 Gonçalves, Juliana
Juliano, A. Margarida
Lopes, David G.
Canhão, Helena
Soares, Helena
Serrano, e. Fátima
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Charepe, Nadia
Gonçalves, Juliana
Juliano, A. Margarida
Lopes, David G.
Canhão, Helena
Soares, Helena
Serrano, e. Fátima
dc.subject.por.fl_str_mv Antibodies
Breastfeeding
Covid-19
mRNA vaccination
Obstetrics and Gynaecology
SDG 3 - Good Health and Well-being
topic Antibodies
Breastfeeding
Covid-19
mRNA vaccination
Obstetrics and Gynaecology
SDG 3 - Good Health and Well-being
description Funding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s).
publishDate 2021
dc.date.none.fl_str_mv 2021-10-22T03:43:03Z
2021-12
2021-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/126480
url http://hdl.handle.net/10362/126480
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2393
PURE: 33996755
https://doi.org/10.1186/s12884-021-04051-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138063676342272

Registros relacionados