Intracellular signaling mechanisms in photodynamic therapy

Detalhes bibliográficos
Autor(a) principal: Almeida, Ramiro D.
Data de Publicação: 2004
Outros Autores: Manadas, Bruno J., Carvalho, Arsélio P., Duarte, Carlos B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5382
https://doi.org/10.1016/j.bbcan.2004.05.003
Resumo: In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may occur by apoptosis or by necrosis, depending on the sensitizer, on the PDT dose and on the cell genotype. Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in inducing apoptotic cell death, both in vitro and in vivo. In this review we will focus on the events that characterize apoptotic death in PDT and on the intracellular signaling events that are set in motion in photosensitized cells. Activation of phospholipases, changes in ceramide metabolism, a rise in the cytosolic free Ca2+ concentration, stimulation of nitric oxide synthase (NOS), changes in protein phosphorylation and alterations in the activity of transcription factors and on gene expression have all been observed in PDT-treated cells. Although many of these metabolic reactions contribute to the demise process, some of them may antagonize cell death. Understanding the signaling mechanisms in PDT may provide means to modulate the PDT effects at the molecular level and potentiate its antitumor effectiveness.
id RCAP_ccea20fd838622e1ecb98accb5ccdb57
oai_identifier_str oai:estudogeral.uc.pt:10316/5382
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Intracellular signaling mechanisms in photodynamic therapyPhotodynamic therapyApoptosisNecrosisCalciumPhosphorylationIn photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may occur by apoptosis or by necrosis, depending on the sensitizer, on the PDT dose and on the cell genotype. Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in inducing apoptotic cell death, both in vitro and in vivo. In this review we will focus on the events that characterize apoptotic death in PDT and on the intracellular signaling events that are set in motion in photosensitized cells. Activation of phospholipases, changes in ceramide metabolism, a rise in the cytosolic free Ca2+ concentration, stimulation of nitric oxide synthase (NOS), changes in protein phosphorylation and alterations in the activity of transcription factors and on gene expression have all been observed in PDT-treated cells. Although many of these metabolic reactions contribute to the demise process, some of them may antagonize cell death. Understanding the signaling mechanisms in PDT may provide means to modulate the PDT effects at the molecular level and potentiate its antitumor effectiveness.http://www.sciencedirect.com/science/article/B6T23-4CNXHDF-1/1/3985caebee735db34936ae02462172be2004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5382http://hdl.handle.net/10316/5382https://doi.org/10.1016/j.bbcan.2004.05.003engBiochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1704:2 (2004) 59-86Almeida, Ramiro D.Manadas, Bruno J.Carvalho, Arsélio P.Duarte, Carlos B.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-23T10:11:24Zoai:estudogeral.uc.pt:10316/5382Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:27.995550Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Intracellular signaling mechanisms in photodynamic therapy
title Intracellular signaling mechanisms in photodynamic therapy
spellingShingle Intracellular signaling mechanisms in photodynamic therapy
Almeida, Ramiro D.
Photodynamic therapy
Apoptosis
Necrosis
Calcium
Phosphorylation
title_short Intracellular signaling mechanisms in photodynamic therapy
title_full Intracellular signaling mechanisms in photodynamic therapy
title_fullStr Intracellular signaling mechanisms in photodynamic therapy
title_full_unstemmed Intracellular signaling mechanisms in photodynamic therapy
title_sort Intracellular signaling mechanisms in photodynamic therapy
author Almeida, Ramiro D.
author_facet Almeida, Ramiro D.
Manadas, Bruno J.
Carvalho, Arsélio P.
Duarte, Carlos B.
author_role author
author2 Manadas, Bruno J.
Carvalho, Arsélio P.
Duarte, Carlos B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Almeida, Ramiro D.
Manadas, Bruno J.
Carvalho, Arsélio P.
Duarte, Carlos B.
dc.subject.por.fl_str_mv Photodynamic therapy
Apoptosis
Necrosis
Calcium
Phosphorylation
topic Photodynamic therapy
Apoptosis
Necrosis
Calcium
Phosphorylation
description In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may occur by apoptosis or by necrosis, depending on the sensitizer, on the PDT dose and on the cell genotype. Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in inducing apoptotic cell death, both in vitro and in vivo. In this review we will focus on the events that characterize apoptotic death in PDT and on the intracellular signaling events that are set in motion in photosensitized cells. Activation of phospholipases, changes in ceramide metabolism, a rise in the cytosolic free Ca2+ concentration, stimulation of nitric oxide synthase (NOS), changes in protein phosphorylation and alterations in the activity of transcription factors and on gene expression have all been observed in PDT-treated cells. Although many of these metabolic reactions contribute to the demise process, some of them may antagonize cell death. Understanding the signaling mechanisms in PDT may provide means to modulate the PDT effects at the molecular level and potentiate its antitumor effectiveness.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5382
http://hdl.handle.net/10316/5382
https://doi.org/10.1016/j.bbcan.2004.05.003
url http://hdl.handle.net/10316/5382
https://doi.org/10.1016/j.bbcan.2004.05.003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1704:2 (2004) 59-86
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133841706713088