Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy

Detalhes bibliográficos
Autor(a) principal: Ribeiro,Joselito Nardy
Data de Publicação: 2004
Outros Autores: Silva,André Romero da, Jorge,Renato Atilio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000600005
Resumo: Photodynamic therapy (PDT), a promising cancer treatment that employs a combination of a photosensitizing chemical, oxygen, and visible light, induces apoptosis in tumor cells. However, the precise mechanism of PDT-induced apoptosis is not well characterized. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT are localized in or have a major influence on mitochondria. The treatment with PDT causes mitochondrial damage and induces apoptosis through the release of cytochrome c (cyt c), apoptosis-inducing factor (AIF), Smac/DIABLO and certain procaspases. Proapoptotic and antiapoptotic members of BcL-2 family regulate the release of these proteins from mitochondria. The purpose of this mini-review is to present some recent publications that focus on the involvement of the mitochondria in apoptosis of cancer cells induced by PDT.
id SBP-1_4245f22bfc75e7fcdd98177914ae154c
oai_identifier_str oai:scielo:S1676-24442004000600005
network_acronym_str SBP-1
network_name_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository_id_str
spelling Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapyPhotodynamic therapyApoptosisMitochondriaPhotodynamic therapy (PDT), a promising cancer treatment that employs a combination of a photosensitizing chemical, oxygen, and visible light, induces apoptosis in tumor cells. However, the precise mechanism of PDT-induced apoptosis is not well characterized. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT are localized in or have a major influence on mitochondria. The treatment with PDT causes mitochondrial damage and induces apoptosis through the release of cytochrome c (cyt c), apoptosis-inducing factor (AIF), Smac/DIABLO and certain procaspases. Proapoptotic and antiapoptotic members of BcL-2 family regulate the release of these proteins from mitochondria. The purpose of this mini-review is to present some recent publications that focus on the involvement of the mitochondria in apoptosis of cancer cells induced by PDT.Sociedade Brasileira de Patologia Clínica2004-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000600005Jornal Brasileiro de Patologia e Medicina Laboratorial v.40 n.6 2004reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442004000600005info:eu-repo/semantics/openAccessRibeiro,Joselito NardySilva,André Romero daJorge,Renato Atilioeng2005-02-14T00:00:00Zoai:scielo:S1676-24442004000600005Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2005-02-14T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
title Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
spellingShingle Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
Ribeiro,Joselito Nardy
Photodynamic therapy
Apoptosis
Mitochondria
title_short Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
title_full Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
title_fullStr Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
title_full_unstemmed Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
title_sort Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy
author Ribeiro,Joselito Nardy
author_facet Ribeiro,Joselito Nardy
Silva,André Romero da
Jorge,Renato Atilio
author_role author
author2 Silva,André Romero da
Jorge,Renato Atilio
author2_role author
author
dc.contributor.author.fl_str_mv Ribeiro,Joselito Nardy
Silva,André Romero da
Jorge,Renato Atilio
dc.subject.por.fl_str_mv Photodynamic therapy
Apoptosis
Mitochondria
topic Photodynamic therapy
Apoptosis
Mitochondria
description Photodynamic therapy (PDT), a promising cancer treatment that employs a combination of a photosensitizing chemical, oxygen, and visible light, induces apoptosis in tumor cells. However, the precise mechanism of PDT-induced apoptosis is not well characterized. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT are localized in or have a major influence on mitochondria. The treatment with PDT causes mitochondrial damage and induces apoptosis through the release of cytochrome c (cyt c), apoptosis-inducing factor (AIF), Smac/DIABLO and certain procaspases. Proapoptotic and antiapoptotic members of BcL-2 family regulate the release of these proteins from mitochondria. The purpose of this mini-review is to present some recent publications that focus on the involvement of the mitochondria in apoptosis of cancer cells induced by PDT.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000600005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442004000600005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.40 n.6 2004
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
_version_ 1752122293634465792

Registros relacionados