Biological activity of antitumoural MGBG: the structural variable

Detalhes bibliográficos
Autor(a) principal: Marques, M. P. M.
Data de Publicação: 2008
Outros Autores: Gil, F., Calheiros, R., Battaglia, V., Brunati, A., Agostinelli, E., Toninello, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/7581
https://doi.org/10.1007/s00726-007-0009-2
Resumo: The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.
id RCAP_cdb8b32b101734528fd7586af14d4527
oai_identifier_str oai:estudogeral.uc.pt:10316/7581
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str
spelling Biological activity of antitumoural MGBG: the structural variableAdenosylmethionine DecarboxylaseAnimalsAntineoplastic AgentsBinding SitesCalciumCell Membrane PermeabilityComputer SimulationDose-Response Relationship, DrugEnzyme InhibitorsHepatocytesHydrogen-Ion ConcentrationMaleMitochondria, LiverMitoguazoneModels, MolecularQuantum TheoryRatsRats, WistarSpermidineSpermineStructure-Activity RelationshipTime FactorsModels, BiologicalThe present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7581http://hdl.handle.net/10316/7581https://doi.org/10.1007/s00726-007-0009-2engAmino Acids. 34:4 (2008) 555-564Marques, M. P. M.Gil, F.Calheiros, R.Battaglia, V.Brunati, A.Agostinelli, E.Toninello, A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-08-24T08:35:49ZPortal AgregadorONG
dc.title.none.fl_str_mv Biological activity of antitumoural MGBG: the structural variable
title Biological activity of antitumoural MGBG: the structural variable
spellingShingle Biological activity of antitumoural MGBG: the structural variable
Marques, M. P. M.
Adenosylmethionine Decarboxylase
Animals
Antineoplastic Agents
Binding Sites
Calcium
Cell Membrane Permeability
Computer Simulation
Dose-Response Relationship, Drug
Enzyme Inhibitors
Hepatocytes
Hydrogen-Ion Concentration
Male
Mitochondria, Liver
Mitoguazone
Models, Molecular
Quantum Theory
Rats
Rats, Wistar
Spermidine
Spermine
Structure-Activity Relationship
Time Factors
Models, Biological
title_short Biological activity of antitumoural MGBG: the structural variable
title_full Biological activity of antitumoural MGBG: the structural variable
title_fullStr Biological activity of antitumoural MGBG: the structural variable
title_full_unstemmed Biological activity of antitumoural MGBG: the structural variable
title_sort Biological activity of antitumoural MGBG: the structural variable
author Marques, M. P. M.
author_facet Marques, M. P. M.
Gil, F.
Calheiros, R.
Battaglia, V.
Brunati, A.
Agostinelli, E.
Toninello, A.
author_role author
author2 Gil, F.
Calheiros, R.
Battaglia, V.
Brunati, A.
Agostinelli, E.
Toninello, A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marques, M. P. M.
Gil, F.
Calheiros, R.
Battaglia, V.
Brunati, A.
Agostinelli, E.
Toninello, A.
dc.subject.por.fl_str_mv Adenosylmethionine Decarboxylase
Animals
Antineoplastic Agents
Binding Sites
Calcium
Cell Membrane Permeability
Computer Simulation
Dose-Response Relationship, Drug
Enzyme Inhibitors
Hepatocytes
Hydrogen-Ion Concentration
Male
Mitochondria, Liver
Mitoguazone
Models, Molecular
Quantum Theory
Rats
Rats, Wistar
Spermidine
Spermine
Structure-Activity Relationship
Time Factors
Models, Biological
topic Adenosylmethionine Decarboxylase
Animals
Antineoplastic Agents
Binding Sites
Calcium
Cell Membrane Permeability
Computer Simulation
Dose-Response Relationship, Drug
Enzyme Inhibitors
Hepatocytes
Hydrogen-Ion Concentration
Male
Mitochondria, Liver
Mitoguazone
Models, Molecular
Quantum Theory
Rats
Rats, Wistar
Spermidine
Spermine
Structure-Activity Relationship
Time Factors
Models, Biological
description The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/7581
http://hdl.handle.net/10316/7581
https://doi.org/10.1007/s00726-007-0009-2
url http://hdl.handle.net/10316/7581
https://doi.org/10.1007/s00726-007-0009-2
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amino Acids. 34:4 (2008) 555-564
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1777302657532166144

Registros relacionados