Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Morgado, Manuel
Data de Publicação: 2011
Outros Autores: Morgado, Sandra, Mendes, Liliana, Pereira, Luísa, Castelo-Branco, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/658
Resumo: A literature review and meta–analysis showed that pharmacist interventions can significantly improve medication adherence, SBP, DBP, and BP control in patients with essential hypertension. Interventions were complex and multifaceted and included medication management in all analyzed studies.
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spelling Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysisBlood pressureComplianceHypertensionHypotensive agentsInterventionsPatientsPharmacistsA literature review and meta–analysis showed that pharmacist interventions can significantly improve medication adherence, SBP, DBP, and BP control in patients with essential hypertension. Interventions were complex and multifaceted and included medication management in all analyzed studies.Purpose. Pharmacist interventions to enhance blood pressure (BP) control and adherence to antihypertensive therapy in adults with essential hypertension were reviewed. Methods. A literature search was conducted to identify relevant articles describing pharmacist interventions intended to improve adherence to antihypertensive medications. Studies were included if they described a pharmacist intervention to improve medication adherence and analyzed adherence to therapy and BP control as outcomes. A fixed-effects model was used to combine data from randomized controlled trials. Results. A total of 15 studies were identified, testing 16 different interventions and containing data on 3280 enrolled patients. Although 87.5% of the interventions resulted in significant improvements in treatment outcomes, only 43.8% of the interventions were associated with significant increases in medication adherence. All interventions that increased antihypertensive medication adherence also significantly reduced BP. Almost all the interventions that were effective in increasing adherence to medication were complex, including combinations of different strategies. Meta-analysis of 2619 patients in 8 studies found that pharmacist interventions significantly reduced systolic blood pressure (SBP) (p < 0.001) and diastolic blood pressure (DBP) (p = 0.002) and that the meta-analytic differences in SBP and DBP changes from baseline to endpoint in intervention and control groups were –4.9 ± 0.9 mm Hg (p < 0.001) and –2.6 ± 0.9 mm Hg (p < 0.001), respectively. Conclusion. A literature review and meta-analysis showed that pharmacist interventions can significantly improve medication adherence, SBP, DBP, and BP control in patients with essential hypertension. Interventions were complex and multifaceted and included medication management in all analyzed studies.Supported by fellowship grant SFRH/BD/36756/2007 from the Fundação para a Ciência e a Tecnologia.American Society of Health-System PharmacistsuBibliorumMorgado, ManuelMorgado, SandraMendes, LilianaPereira, LuísaCastelo-Branco, Miguel2011-01-26T21:37:08Z2011-02-012011-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/658eng1079-2082info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:35:58Zoai:ubibliorum.ubi.pt:10400.6/658Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:42:42.400023Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
title Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
spellingShingle Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
Morgado, Manuel
Blood pressure
Compliance
Hypertension
Hypotensive agents
Interventions
Patients
Pharmacists
title_short Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
title_full Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
title_fullStr Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
title_full_unstemmed Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
title_sort Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis
author Morgado, Manuel
author_facet Morgado, Manuel
Morgado, Sandra
Mendes, Liliana
Pereira, Luísa
Castelo-Branco, Miguel
author_role author
author2 Morgado, Sandra
Mendes, Liliana
Pereira, Luísa
Castelo-Branco, Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Morgado, Manuel
Morgado, Sandra
Mendes, Liliana
Pereira, Luísa
Castelo-Branco, Miguel
dc.subject.por.fl_str_mv Blood pressure
Compliance
Hypertension
Hypotensive agents
Interventions
Patients
Pharmacists
topic Blood pressure
Compliance
Hypertension
Hypotensive agents
Interventions
Patients
Pharmacists
description A literature review and meta–analysis showed that pharmacist interventions can significantly improve medication adherence, SBP, DBP, and BP control in patients with essential hypertension. Interventions were complex and multifaceted and included medication management in all analyzed studies.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-26T21:37:08Z
2011-02-01
2011-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/658
url http://hdl.handle.net/10400.6/658
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1079-2082
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society of Health-System Pharmacists
publisher.none.fl_str_mv American Society of Health-System Pharmacists
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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