Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

• Autor(a) principal: Matos,Andreia Carvalho de
• Data de Publicação: 2022
• Outros Autores: Macedo,Cristiane Pais, Mendes,Patrícia Afonso, Cipriano,Maria Augusta, Paiva,Artur, Simão,Adélia
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452022000400051
• topic: Autoimmune hepatitis; Nitrofurantoin toxicity; Interstitial pulmonary disease

Abstract Antibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin-induced autoimmune hepatitis and lung fibrosis that fulfills the definitive clinical criteria for diagnosis, presenting histological, imagiological, and immunological evidence of nitrofurantoin-induced toxicity. It occurred in a 68-year-old woman with extended nitrofurantoin intake for urinary tract infection prophylaxis who presented with progressive exercise dyspnea and jaundice. Similar published cases are also reviewed in this article.