Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases

Detalhes bibliográficos
Autor(a) principal: Lêdo, Susana
Data de Publicação: 2018
Outros Autores: Ramires, Ana, Leite, Ângela, Dinis, Maria Alzira Pimenta, Sequeiros, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/7906
Resumo: http://sherpa.ac.uk/romeo/issn/1769-7212/
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spelling Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseasesAdultAgedAmyloid Neuropathies, FamilialAnxietyAsymptomatic DiseasesFactitious DisordersFemaleGenetic CounselingHumansHuntington DiseaseMaleMiddle AgedGenetic Testinghttp://sherpa.ac.uk/romeo/issn/1769-7212/This longitudinal study aimed at determining predicting variables for middle and long-term psychological disturbance due pre-symptomatic testing (PST) for two late-onset neurological diseases, Huntington disease (HD) and TTR (transthyretin protein) familial amyloid polyneuropathy (FAP) Val30Met (now classified as Val50Met). 196 clinical records of persons who performed PST at least three years ago and answered to the two stages of evaluation (before PST and least 3 years after disclosure of results) were analysed. For this purpose, regression analysis was performed, showing that the Positive Symptom Distress Index (PSDI), psychoticism, somatization and paranoid ideation dimensions assume predictive value in the middle and long-term impact for total anxiety and PSDI. The result of PST was not a relevant predictor. The application of an evaluation instrument of various psychopathological dimensions played a fundamental role in the detection of clinical situations that may arise several years later after PST. Attention should be paid to providing psychological support to persons at-risk who, at the pre-test phase, present some psychopathology indices before pursuing with genetic testing.ElsevierRepositório Institucional da Universidade Fernando PessoaLêdo, SusanaRamires, AnaLeite, ÂngelaDinis, Maria Alzira PimentaSequeiros, Jorge2019-09-16T08:47:05Z2018-01-01T00:00:00Z2018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/7906engAPA: Lêdo, S., Ramires, A., Leite, Â., Dinis, M. A. P., & Sequeiros, J. (2018). Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases. European Journal of Medical Genetics, 61(10), 575-580. doi:10.1016/j.ejmg.2018.03.0101878-084910.1016/j.ejmg.2018.03.010metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:16Zoai:bdigital.ufp.pt:10284/7906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:44:49.007118Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
title Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
spellingShingle Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
Lêdo, Susana
Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Factitious Disorders
Female
Genetic Counseling
Humans
Huntington Disease
Male
Middle Aged
Genetic Testing
title_short Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
title_full Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
title_fullStr Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
title_full_unstemmed Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
title_sort Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
author Lêdo, Susana
author_facet Lêdo, Susana
Ramires, Ana
Leite, Ângela
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
author_role author
author2 Ramires, Ana
Leite, Ângela
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Lêdo, Susana
Ramires, Ana
Leite, Ângela
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
dc.subject.por.fl_str_mv Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Factitious Disorders
Female
Genetic Counseling
Humans
Huntington Disease
Male
Middle Aged
Genetic Testing
topic Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Factitious Disorders
Female
Genetic Counseling
Humans
Huntington Disease
Male
Middle Aged
Genetic Testing
description http://sherpa.ac.uk/romeo/issn/1769-7212/
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01T00:00:00Z
2018-01-01T00:00:00Z
2019-09-16T08:47:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/7906
url http://hdl.handle.net/10284/7906
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv APA: Lêdo, S., Ramires, A., Leite, Â., Dinis, M. A. P., & Sequeiros, J. (2018). Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases. European Journal of Medical Genetics, 61(10), 575-580. doi:10.1016/j.ejmg.2018.03.010
1878-0849
10.1016/j.ejmg.2018.03.010
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130313787441152

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